ObjectiveTo investigate the effects of signaling pathway about the EGFR, MAPK, IKB/NF-κB, PI3K/Akt, WNT/beta-catenin, and the Hedgehog in development of hepatocellular carcinoma(HCC). MethodsThe related literatures about the molecular genetic mechanism of signaling pathways were reviewed. ResultsIn the occurrence and development of HCC, the EGFR, MAPK, IKB/NF-κB, PI3K/Akt, WNT/β-catenin, and Hedgehog signaling pathways not only interweaver with each other complexly, but also interact with each other, and some tumor markers, anticancer genes, proto-oncogenes, and miRNA may have synergistic effects for the occurrence of HCC. ConclusionThe abnormal changes of molecular signaling pathways is a necessary condition for the occurrence and development of tumor, and there is considerable cross-talk and redundancy to many signaling pathways.