OBJECTIVE: To observe the clinical effect of acellular allogenic dermis with split-thickness autogenous skin graft for coverage of wound. METHODS: Acellular allogenic dermis with split-thickness autogenous skin graft was used to repair 34 wounds of head, neck, trunk and extremities. The area of wounds was from 5 cm x 10 cm to 12 cm x 19 cm. Out of 34 wounds, there were 2 due to old granulation, 4 due to excision of giant pigmented nevus, 6 due to excision of capillary hemangioma of skin and 22 due to excision of scar. RESULTS: All grafts survived and had the smooth surface without obvious pigmentation and with slight wound contraction. CONCLUSION: Acellular allogenic dermis with autologous epithelium for coverage of various wounds is an ideal procedure.