【摘要】 目的 探討基因重組人生長激素（recombinant human growth hormone，rhGH）及雌/孕激素（estrogen/progestogem，E/P）治療對Turner綜合征（Turner syndrome，TS）患兒身高及性征發育的影響。 方法 2005年1月—2009年6月四川大學華西第二醫院門診就診TS患兒22例，12例患兒接受rhGH治療，年齡（13.58±2.23）歲，劑量0.15 U/（kg?d），睡前皮下注射，療程4~24個月。16例年齡≥13歲、骨齡≥11歲的患兒接受E/P治療，療程3~30個月。 結果 rhGH治療后患兒身高、身高的標準差積分提高，生長速率達（9.33±2.39）cm/年；E/P治療可促進患兒乳房發育及規律月經出現。 結論 rhGH和E/P治療對TS患兒身高增長及性征發育有明顯療效。【Abstract】 Objective To explore the therapeutic effects of recombinant human growth hormone (rhGH) and sex hormone on the stature and sex feature of children with Turner syndrome (TS). Methods A total of 22 children with TS were selected in the outpatients department of West China Second Hospital between January 2005 and June 2009. Twelve children with TS the average age of (13.58±2.23) years received rhGH [0.15 U/(kg?d)] every night before sleep for 4-24 months . Sixteen children with TS (age≥14 years old, bone age≥11 years old) underwent estrogen and progestogen (E/P) treatment for 3-30 months. Results The height and height standard deviation score increased significantly in children with rhGH therapy (Plt;0.01). The height velocity was (9.33±2.39) cm/year after the treatment. The treatment of estrogen and progestogen could promote the development of breast and establish menstrual cycle in children with TS. Conclusion rhGH and E/P can play a significant role in treatment of TS in children.