摘要:目的:分析本院住院城鎮及農村患者的乙型肝炎病毒感染及免疫情況,推測不同區域發病及免疫狀況,為免疫預防及臨床提供參考。方法:收集我科2000年度,2004年度,2008年度住院患者的乙肝五項檢測報告,按患者長期居住地分為農村組及城鎮組,對比分析兩組患者乙型肝炎病毒感染、具有免疫力及無免疫力年度變化情況及不同組別的差異。結果:同農村組相比,城鎮組乙型肝炎病毒感染率、無免疫率低于農村組,免疫率高于農村組。年度對比乙型肝炎病毒感染率及免疫率呈上升趨勢,無免疫率呈下降趨勢。結論:近年來乙型病毒性肝炎發病有上升趨勢,農村地區免疫普及率相對較低,仍為發病及預防免疫的重點區域,應給予足夠重視。Abstract: Objective: To observe the disposition of infection and immunifaction on type B hepatitis in patients from hospital, suppose the disposition of infection and immunifaction in differently region, and provide information for immunifaction and clinical treatment. Methods: Reports of type B hepatitis from patients in hospital were collected, and were divided into town group and country group according to the habitation of patients. The difference of infection, immunifaction and no immunifaction were compared between two groups. Results: In comparison with the country group, the percentage of infection and no immunifaction was lower in town, and immunifaction was higher, attack rate of type B hepatitis had a tendency to increasing and no immunifaction was decreased by contrasting with annum. Conclusion: Recent years, attack rate of type B hepatitis has a tendency to increasing, and the popular rate of immunifaction is lower in country, so country is still the focal point of immunifaction and infection, and sufficient attention must be paid.
目的 探討透明質酸（HA）延遲創面愈合的作用。方法 成年日本大耳白兔8只，建立兔耳創傷愈合模型，隨機分成2%HA治療組（A組），1%HA治療組（B組），磷酸鹽緩沖液（PBS）對照組（C組，進行大體形態、組織學變化、平均愈合時間、創面收縮情況、殘余創面面積、成纖維細胞α-平滑肌肌動蛋白表達及超微結構，觀察12天。結果 ①三組創面平均愈合時間為（11.7±0.6）、（11.3±0.6）和（10.8±1.0）天,三組之間有顯著差異（Plt;0.05）；A、B組與C組比較創面收縮速率及殘余面積也有統計學意義（Plt;0.05）。②組織學見A、B兩組膠原纖維較細，排列整齊；C組膠原纖維較粗大，排列紊亂。③ A、B組α平滑肌肌動蛋白的表達少于C組，有統計學意義（Plt;0.01）。結論 HA通過抑制成纖維細胞向肌成纖維細胞轉化而抑制創面收縮，是延遲創面愈合的原因之一；且這一作用與其濃度有依賴關系。