【摘要】 目的 觀察在表面麻醉下不作結膜瓣和傳統的以穹窿為基底結膜切開的小切口白內障摘除聯合5.5 mm直徑人工晶狀體植入術的臨床效果。 方法 收集2007年1月-2010年12月資料較完整的老年性白內障160例,將160例320只眼隨機分成兩組,每組各80例160只眼。在表面麻醉下行小切口白內障手術。A組不做結膜瓣,行長5.5 mm角鞏膜緣的平行切口; B組行以穹窿為基底的傳統的結膜瓣,做長5.5 mm角鞏膜平行切口;兩組均行手法小切口白內障劈核摘除聯合5.5 mm直徑硬質人工晶狀體植入。觀察術后效果及術后并發癥。 結果 術后1個月,患者眼部舒適者:A組154只眼(96.25%),B組141只眼(88.13%),兩組差異有統計學意義(χ2=7.332,Plt;0.05)。術后結膜退縮、下垂、巨大瘢痕:A組7只眼(4.38%),B組29只眼(18.13%),兩組差異有統計學意義(χ2=15.149,Plt;0.01),兩組患者術后1 d、1周及1個月視力比較:1 d,A組120只眼(75.00%),B組128只眼(80.00%)(χ2=1.467,Pgt;0.05);1周,A組130只眼(81.25%),B組132只眼(82.25%)(χ2=0.084,Pgt;0.05);1個月,A組138只眼(86.25%),B組139只眼(86.86%)(χ2=0.027,Pgt;0.05);角膜水腫于術后2周后均消退。 結論 在表面麻醉下不做結膜瓣較做結膜瓣小切口白內障劈核摘除術聯合人工晶狀體植入術省時、對眼表面破壞小,角鞏膜切口較小且較為隱閉,術后恢復快。在基層醫院是一種較好的白內障手術方法。【Abstract】 Objective To observe the clinical effect of non-conjunctival flaps and traditional conjunctival flaps choper extracapsular cataract extraction (ECCE) on patients with senile cataracts. Methods The clinical data of 160 patients with cataracts between January 2007 and December 2010 were collected. The patients were randomly divided into two groups with 80 patients (160 eyes) in each group. The patients in group A underwent the small-incision choper ECCE surgery with non-conjunctival flaps; while the patients in group B underwent the traditional conjunctival flaps. Then the total effective rate, incidence of complications, and satisfaction rate of the two groups were analyzed and compared. Results One month after the surgery, the comfort was found in 154 eyes (96.25%) in group A and in 141 eyes (88.13%) in group B; the difference was significant (χ2=7.332,Plt;0.05). The complications after the surgery including conjunctiva retraction, nutation, and huge scar were found in 7 eyes (4.38%) in group A and in 29 eyes (18.13%) in group B, and the difference was significant (χ2=15.149,Plt;0.01) . The visual acuity of the patients one day, one week and one month after the surgery in the two groups were: one day: 120 eyes (75.00%) in group A and 128 eyes (80.00%) in group B (χ2=1.467,Pgt;0.05); one week: 130 eyes (81.25%) in group A and 132 eyes (82.25%) in group B (χ2=0.084,Pgt;0.05); one month: 138 eyes (86.25%) in group A and 139 eyes (86.86%) in group B (χ2=0.027,Pgt;0.05). The cornea edema was alleviated half month after the surgery. Conclusion Compared with the traditional way, non-conjunctival flaps ECCE may save the surgical time, reduce the damage of the ocular surface, improve the visual acuity and received higher satisfaction rate and less conjunctive complication, which is a good surgical method in local hospital.
目的研究高原地區建設者骨形成標志物骨特異性堿性磷酸酶(bone-specific alkaline phosphatase,BALP)和骨吸收標志物Ⅰ型膠原交聯羧基端肽區(type Ⅰ collagen cross-linked C-telopeptide,CTX)、抗酒石酸酸性磷酸酶(tartrate-resistant acid phosphatase,TRAP)-5b 的分布特征,分析其高原環境下的影響因素。方法2014 年 4 月—5 月在海拔 2 600~4 450 m[平均海拔(3 586.50±610.85)m]的四川省甘孜州巴塘縣、西藏自治區芒康縣境內,采用隨機整群抽樣的方式,抽取 650 名建設者作為研究對象,采集其空腹血,應用酶聯免疫吸附試驗檢測血清 BALP、CTX 和 TRAP-5b。應用 SPSS 13.0 軟件分析年齡、工作強度、高原停留時間、工作地海拔高度等對骨代謝標志物的影響規律,探索高原環境下骨代謝標志物的主要影響因素。結果CTX、TRAP-5b 和 BALP 在 20 歲以下處于最高水平[CTX 為(1.04±0.38)ng/mL,BALP 為(52.09±14.62)μg/L,TRAP-5b 為(4.22±1.38)U/L],以后隨年齡增長均呈下降趨勢,但 CTX 及 BALP 在 40~49 歲年齡組達到最低[CTX 為(0.44±0.26)ng/mL,BALP 為(24.77±9.89)μg/L],50 歲后開始升高;而 TRAP-5b 在 30~39 歲年齡組達到最低[(2.59±0.95)U/L],40 歲后開始升高。隨著海拔高度增加,BALP 和 CTX 的活性明顯升高。隨著勞動強度增加,BALP、TRAP-5b 與 CTX 均增高。但無論何種勞動強度,隨著高原停留時間延長,BALP 先升高后降低;而 TRAP-5b 先降低后升高。結論骨代謝標志物在不同年齡段分布不同。海拔高度、工作強度及高原工作時間對骨代謝標志物有顯著影響。