目的:探討癲癇發作致燒傷的臨床特點及防治措施。方法:在系統抗癲癇的前提下，在抗休克、預防感染、營養支持等全身治療同時，積極采用手術方法及早修復創面，結合良好的心理調試及護理。結果:該組43例患者除3例未完成治療外，其余40例均痊愈出院，住院時間10~42天，住院期間出現癲癇再發作1例，經調整用藥后控制，均無并發癥發生。結論:采取系統的抗癲癇藥物治療與早期積極進行燒傷創面手術，全身和心理治療并重的綜合治療方法，可使創面及早痊愈，明顯降低癲癇再發作，是治療癲癇合并燒傷的有效方法。
Objective To investigate the effects of glutathione (GSH) on survival of the random skin flap in rats and the probable mechanism that contribute to this effect. Methods Twenty SD rats with 200-250 g in weight, were randomly divided into the experimental group and control group(n=10). Random flap of 8 cm×2 cm in size was made on the back of each rat with the pedicel on the angular of the scapular. GSH(250 mg/kg) and NS of the same dose were injected into the abdominal cavity of rats in the experimental groupand the control group immediately after the operative, 1st and 2nd days respectively. The rats were killed on the 7th day after the operation. The tissue pathology, the survival rate of the flap, the superoxide dismutase(SOD) activity and malonyldialdehyde (MDA) level were compared between two groups. Results The mean survival rate of the flap on the 7th day in the experimental group（56.77%±10.67%） was higher than that in the control group(40.16%±7.12%)(Plt;0.05).SOD activity in experimental group （306.06±84.87 U/mgprot）was higher than that in the control group （224.79±27.12 U/mgprot）, while MDA level （3.835±0.457 nmol/mgprot）was lower than that in the control group (6.127±0.837 nmol/mgprot)(Plt;0.05). Histological observation showed that the neutrophil infiltration was less in experimental group than that in the control group; that the experimental group was surperior to the control group in angiogenesis, fibroblasts, fair cells and cuaneous gland. Conclusion The intraperitoneal use of GSH may promote the survival rate of the random flaps and the possible mechanism for improvement may lies in that the GSH can reduce the level of oxygen free radical and lipidperoxidation,and lessen neutrophil infiltration.
目的 探討瘢痕或皮膚腫瘤切除后創面使用皮能快愈敷料（PELNAC，商品名：皮耐克）結合自體刃厚皮覆蓋的治療效果。 方法 回顧分析2010年1月－2013年1月收治的兩組瘢痕或皮膚腫瘤切除術后創面分別使用不同皮片覆蓋的治療效果。A組6例，采用PELANC與自體刃厚皮片復合移植；B組10例，采用自體中厚皮片移植修復。隨訪近期、遠期，對比評估兩組創面存活的皮片外觀，彈性；供皮區愈合情況。 結果 兩組患者皮片完全成活，外觀好，彈性佳，較術前明顯改善。與B組相比，A組供皮區愈合時間短，愈合后色素沉著輕微，無明顯疤痕形成。 結論 采用PELNAC與自身刃厚皮片復合移植修復瘢痕或腫瘤切除后創面，既能夠顯著改善外觀、功能，達到理想的創面修復效果，又不會造成供皮區的繼發性瘢痕增生，是一種理想的創面修復方式。