各位新年好!
國際知名的基因治療雜志Human Gene Therapy《人類基因治療》春節期間發表了中國專刊，劉德培院士和魏于全院士受邀作為客座主編，該專輯發表了18篇中國科學家寫的評論, 綜述和原創研究文章，內容涉及基因與細胞治療藥物監管、病毒與非病毒載體、基因編輯、基因修飾的干細胞治療等技術，以及基因治療與細胞治療在腫瘤、心血管疾病、遺傳性疾病等方面的應用進展、反映了中國科學家在該領域取得的最新進展，論文目錄詳見該文最后，閱讀全文見http://online.liebertpub.com/toc/hum/29/2。
Human Gene Therapy的主編Terence R. Flotte教授與美國基因與細胞治療學會主席，Guangping Gao教授 (高光坪教授)，用中英文同時發表了編者按 “Gene and Cell Therapy in China: Highlighting Excellence in the 21st Century” （中國的基因與細胞治療：21世紀的飛躍發展和重要貢獻）。他們指出：“值此中國農歷新年之際, 我們很榮幸能在《人類基因治療》雜志上發表本期由劉德培教授和魏于全教授這兩位中國基因和細胞治療領域的領軍人物客串主編的中國特刊。在本特刊中, 我們不僅收集了一系列的評論, 綜述和原創研究文章, 同時, 我們還力求重點介紹這個世界上人口最多而科學和技術正在以前所未有的速度飛躍發展的國家在基因和細胞治療轉化研究領域里所取得的成就和重要貢獻……..”。
封面由川大華西醫院生物治療國家重點實驗室的李昕欣博士與王瑋副教授設計，其設計的靈感來源于女媧補天這個典故。相傳在中國遠古時代，四根擎天大柱傾倒，天空出現巨大的洞口，九州大地裂毀，一時間生靈涂炭。此時女媧冶煉五色石，以修補蒼天，將有缺陷的天空修補完整，自此中原大地上恢復了平靜，世間萬物皆依照秩序運轉。而基因治療的原理則是將外源正常基因導入靶細胞，以糾正或補償因基因缺陷和異常引起的疾病，以達到治療目的，與女媧補天的典故想契合。更重要的是，女媧補天展現了人類改造天地的雄偉氣魄和與自然斗爭的大無畏精神，基因治療的探索亦是體現人類與自然不懈抗爭的精神，二者在精神層面互通，采用此典故表現基因治療的概念可以說渾然天成。
Special Issue: Chinese Gene and Cell Therapy Research
Guest Editors: Yuquan Wei, MD, PhD, and De-Pei Liu, MD, PhD
Gene and Cell Therapy in China: Highlighting Excellence in the 21st Century 中國的基因與細胞治療： 21世紀的飛躍發展和重要貢獻
Terence R. Flotte, Guangping Gao (高光坪)
Human Gene Therapy. Feb 2018, 29(2): 97-97.
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Special Commentaries and Review Articles
Applications of Virus Vector–Mediated Gene Therapy in China
Qiong Lin, Deng-Gao Wang, Zhu-Qin Zhang, De-Pei Liu
Human Gene Therapy. Feb 2018, 29(2): 98-109.
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Current Status of Nonviral Vectors for Gene Therapy in China
Li Liu, Jingyun Yang, Ke Men, Zhiyao He, Min Luo, Zhiyong Qian, Xiawei Wei, Yuquan Wei
Human Gene Therapy. Feb 2018, 29(2): 110-120.
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Considerations for Clinical Review of Cellular Therapy Products: Perspectives of the China Food and Drug Administration Center for Drug Evaluation
Yantong Liu, Chenyang Zhao, Liucun Gao, Huan Yang, Ruyi He, Chenyan Gao
Human Gene Therapy. Feb 2018, 29(2): 121-127.
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National Rare Diseases Registry System of China and Related Cohort Studies: Vision and Roadmap
Shi Feng, Shuang Liu, Chong Zhu, Mengchun Gong, Yicheng Zhu, Shuyang Zhang
Human Gene Therapy. Feb 2018, 29(2): 128-135.
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Recent Advances in Therapeutic Genome Editing in China
Yang Yang, Qingnan Wang, Qian Li, Ke Men, Zhiyao He, Hongxin Deng, Weizhi Ji, Yuquan Wei
Human Gene Therapy. Feb 2018, 29(2): 136-145.
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Gene Therapy for Hemophilia and Duchenne Muscular Dystrophy in China
Xionghao Liu, Mujun Liu, Lingqian Wu, Desheng Liang
Human Gene Therapy. Feb 2018, 29(2): 146-150.
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Fighting Cancer with Viruses: Oncolytic Virus Therapy in China
Ding Wei, Jing Xu, Xin-Yuan Liu, Zhi-Nan Chen, Huijie Bian
Human Gene Therapy. Feb 2018, 29(2): 151-159.
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The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic
Wei-Wei Zhang, Longjiang Li, Dinggang Li, Jiliang Liu, Xiuqin Li, Wei Li, Xiaolong Xu, Michael J. Zhang, Lois A. Chandler, Hong Lin, Aiguo Hu, Wei Xu, Dominic Man-Kit Lam
Human Gene Therapy. Feb 2018, 29(2): 160-179.
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Development of Gene Therapeutics for Head and Neck Cancer in China: From Bench to Bedside
Wei Guo, Hao Song
Human Gene Therapy. Feb 2018, 29(2): 180-187.
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Stem-Cell Therapy Advances in China
Lei Hu, Bin Zhao, Songlin Wang
Human Gene Therapy. Feb 2018, 29(2): 188-196.
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Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World
Jingzhi Zhang, Jingbin Yan, Fanyi Zeng
Human Gene Therapy. Feb 2018, 29(2): 197-203.
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Oncolytic Viruses for Tumor Precision Imaging and Radiotherapy
Zi J. Wu, Feng R. Tang, Zhao-Wu Ma, Xiao-Chun Peng, Ying Xiang, Yanling Zhang, Jingbo Kang, Jiafu Ji, Xiao Q. Liu, Xian-Wang Wang, Hong-Wu Xin, Bo X. Ren
Human Gene Therapy. Feb 2018, 29(2): 204-222.
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Research Articles
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9
Zhi-Yao He, Ya-Guang Zhang, Yu-Han Yang, Cui-Cui Ma, Ping Wang, Wei Du, Ling Li, Rong Xiang, Xiang-Rong Song, Xia Zhao, Shao-Hua Yao, Yu-Quan Wei
Human Gene Therapy. Feb 2018, 29(2): 223-233.
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Interleukin-35 Gene-Modified Mesenchymal Stem Cells Protect Concanavalin A–Induced Fulminant Hepatitis by Decreasing the Interferon Gamma Level
Wei Wang, Hao Guo, Hongyue Li, Yongjia Yan, Chao Wu, Xiaodong Wang, Xianghui He, Na Zhao
Human Gene Therapy. Feb 2018, 29(2): 234-241.
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Treatment of Uterine Sarcoma with rAd-p53 (Gendicine) Followed by Chemotherapy: Clinical Study of TP53 Gene Therapy
Yu Xia, Zhenhua Du, Xinyan Wang, Xiuqin Li
Human Gene Therapy. Feb 2018, 29(2): 242-250.
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Double-Dose Adenovirus-Mediated Adjuvant Gene Therapy Improves Liver Transplantation Outcomes in Patients with Advanced Hepatocellular Carcinoma
Ruidong Zhu, Danhui Weng, Shichun Lu, Dongdong Lin, Menglong Wang, Dongdong Chen, Jun Lv, Hongjun Li, Fudong Lv, Ling Xi, Jianfeng Zhou, Ding Ma, Ning Li
Human Gene Therapy. Feb 2018, 29(2): 251-258.
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MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation
Yan Zhang, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang, Airong Qian, Cory J. Xian
Human Gene Therapy. Feb 2018, 29(2): 259-270.
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Transplantation of Hepatocyte Growth Factor–Modified Dental Pulp Stem Cells Prevents Bone Loss in the Early Phase of Ovariectomy-Induced Osteoporosis
Fanxuan Kong, Xuefeng Shi, Fengjun Xiao, Yuefeng Yang, Xiaoyan Zhang, Li-Sheng Wang, Chu-Tse Wu, Hua Wang
Human Gene Therapy. Feb 2018, 29(2): 271-282.
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Signal Transduction and Targeted Therapy簡介
《Signal Transduction and Targeted Therapy》（STTT）是自然出版集團和四川大學華西醫院生物治療國家重點實驗室合作出版的全英文生物醫學專業期刊（網站：http://www.nature. com/sigtrans，點擊本網站最下方"閱讀原文”）。主編由美國俄亥俄州立大學Carlo M. Croce教授（美國三院院士，Cancer Research前主編），UCSD的張康教授、川大華西醫院魏于全教授/院士擔任。有來自全球等多個國家及地區的多位相關領域的近百位著名學者組成編委會。本雜志每周五發表文章，歡迎各位投稿，包括論著或綜述。對于原創性成果采取“快速通道”模式，幫助作者以最快的速度發表文章，最快一周可接收。該雜志發表論文可免收發表費。該雜志投稿格式不限，正式發表之前再按雜志格式修改。感謝將此信息轉發給您們的同事、朋友以及學生等。
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