重癥急性胰腺炎并發感染的早期預防_《中國普外基礎與臨床雜志》

作者：

魏巍 ,  兌丹華

遵義醫學院附屬醫院肝膽胰外科（貴州遵義 563003）;

關鍵詞：

重癥急性胰腺炎感染死亡率預防

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　探討重癥急性胰腺炎（severe acute pancreatitis，SAP）并發感染的早期預防措施。
方法　復習國內外近10年來關于SAP并發感染方面的文獻，討論早期采取措施對SAP并發感染的影響。
結果　早期應用易透過血-胰屏障的抗生素，合理使用質子泵抑制劑，盡早給予腸內營養、血液濾過、高壓氧等治療，再配合中醫治療，可以減少SAP時感染的發生，提高其治愈率。
結論　SAP并發感染是后期患者死亡的主要原因之一，在SAP早期采取綜合有效的治療措施，可降低感染率；但仍有些問題尚不清楚，需進一步探索。

引用本文： 魏巍,兌丹華. 重癥急性胰腺炎并發感染的早期預防. 中國普外基礎與臨床雜志, 2013, 20(6): 697-703. doi: 復制

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28. Marik PE. What is the best way to feed patients with pancreatitis?[J]. Curr Opin Crit Care， 2009， 15(2)：131-138.
29. Xue P， Deng LH， Xia Q， et al. Impact of alanyl-glutaminedipeptide on severe acute pancreatitis in early stage[J]. World J Gastroenterol， 2008， 14(3)：474-478.
30. Zou XP， Chen M， Wei W， et al. Effects of enteral immunonutritionon the maintenance of gut barrier function and immune function in pigs with severe acute pancreatitis[J]. JPEN J Parenter Enteral Nutr， 2010， 34(5)：554-566.
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33. Lutgendorff F， Trulsson LM， van Minnen LP， et al. Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis[J]. Am J Physiol Gastrointest Liver Physiol， 2008， 295(5)：G1111- G1121.
34. Lutgendorff F， Nijmeijer RM， Sandstrom PA， et al. Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis[J]. PloS One， 2009， 4(2)：e4512.
35. Rychter JW， van Minnen LP， Verheem A， et al. Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis[J]. Surgery， 2009， 145(2)：157-167.
36. Plaudis H， Pupelis G， Zeiza K， et al. Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut in patients with severe acute pancreatitis：a prospective feasibility study[J]. Acta Chir Belg， 2012， 112(2)：131-138.
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《中國普外基礎與臨床雜志》

重癥急性胰腺炎并發感染的早期預防

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《中國普外基礎與臨床雜志》

重癥急性胰腺炎并發感染的早期預防

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