繼發性抗磷脂抗體綜合征合并肺栓塞一例_Chinese Journal of Respiratory and Critical Care Medicine

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吉澤 , 倪殿濤

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繼發性抗磷脂抗體綜合征; 肺栓塞

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抗磷脂抗體綜合征( antiphospholipid syndrome,APS) 是指由抗磷脂抗體( antiphospholipid antibody,APL) 引起的一組臨床征象的總稱。臨床表現主要為血栓形成、習慣性流產、血小板減少等。APS 可分為原發性和繼發性[ 1 ] 。如伴發系統性紅斑狼瘡或其他自身免疫性疾病, 稱為繼發性抗磷脂抗體綜合征( secondary APS, SAPS) ; 如單獨出現則稱原發性抗磷脂抗體綜合征( primary APS, PAPS) 。肺臟是
APS 的主要受累器官, 可引起肺栓塞( pulmonary embolism, PE) 等嚴重并發癥。現將我院收治的1 例SAPS合并PE 病例報告如下。

Citation： 吉澤,倪殿濤. 繼發性抗磷脂抗體綜合征合并肺栓塞一例. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(5): 522-524. doi: Copy

1.	Avasthi R, Chaudhary SC, Mohanty D, et al. Severe primary antiphospholipid syndrome. J Assoc Physicians India, 2008, 56: 806 -807.
2.	Dutta TK, Venogopal V. Venous thromboembolism: the intricacies. J Postgrad Med, 2009, 55: 55-64.
3.	Khamashta MA, Hughes syndrome, antiphespholipid syndrome.London: Springer, 2000: 3 -7.
4.	Pierangeli SS, Chen PP, Raschi E, et al. Antiphospholipid antibodiesand the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost, 2008 , 34: 236-250.
5.	Rand JH, Wu XX, Quinn AS, et al. Resistance to annexin A5 anticoagulant activity; a thrombogenic mechanism for the antiphospholipid syndrome. Lupus, 2008 , 17: 922 -930.
6.	Miyakis S, Lockshin MD, Atsumi T, el al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome( APS) . J of Thromb Haemost, 2006, 4 :.
7.	Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome:clinical and immunologic manifestations and patterns of disease expressionin a cohort of 1000 patients. Arthtitis Rheum, 2002, 46 :.
8.	康健, 王辰, 陸慰萱, 等. 肺血栓栓塞癥. 中國實用內科雜志,2006, 26: 1457-1467.
9.	-306.
10.	-1027.

1. Avasthi R, Chaudhary SC, Mohanty D, et al. Severe primary antiphospholipid syndrome. J Assoc Physicians India, 2008, 56: 806 -807.
2. Dutta TK, Venogopal V. Venous thromboembolism: the intricacies. J Postgrad Med, 2009, 55: 55-64.
3. Khamashta MA, Hughes syndrome, antiphespholipid syndrome.London: Springer, 2000: 3 -7.
4. Pierangeli SS, Chen PP, Raschi E, et al. Antiphospholipid antibodiesand the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost, 2008 , 34: 236-250.
5. Rand JH, Wu XX, Quinn AS, et al. Resistance to annexin A5 anticoagulant activity; a thrombogenic mechanism for the antiphospholipid syndrome. Lupus, 2008 , 17: 922 -930.
6. Miyakis S, Lockshin MD, Atsumi T, el al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome( APS) . J of Thromb Haemost, 2006, 4 :.
7. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome:clinical and immunologic manifestations and patterns of disease expressionin a cohort of 1000 patients. Arthtitis Rheum, 2002, 46 :.
8. 康健, 王辰, 陸慰萱, 等. 肺血栓栓塞癥. 中國實用內科雜志,2006, 26: 1457-1467.
9. -306.
10. -1027.

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