哮喘患者呼出氣冷凝液中硝酸鹽/ 亞硝酸鹽、白細胞介素4 和γ干擾素檢測的臨床意義_《中國呼吸與危重監護雜志》

作者：

陳燕文 ,  何權瀛 , 尚穎 , 改軍

北京大學人民醫院呼吸內科（北京 100044）;

關鍵詞：

哮喘呼出氣冷凝液糖皮質激素硝酸鹽/亞硝酸鹽一氧化氮白細胞介素4 γ干擾素

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目的了解哮喘患者呼出氣冷凝液( EBC) 中硝酸鹽/亞硝酸鹽( NO2 /NO3 ) 、IL-4 和 IFN-γ的含量, 并觀察激素治療對其水平的影響。方法納入哮喘患者40 例, 其中初診輕、中度非激素治療組( 未治療組) 20 例, 輕中度慢性持續期激素治療組20 例( 治療組) ; 健康對照20 例。收集 EBC, 測定NO2 /NO3 、IL-4 和IFN-γ含量; 檢測外周血IL-4、IFN-γ含量。結果哮喘未治療組EBC 中 NO2 /NO3 含量顯著高于對照組和治療組[ ( 48.55 ±27. 37) μmol / L 比( 24. 51 ±18. 22) μmol / L、( 36. 06 ±25. 13) μmol / L, P 均 lt;0. 05] , 而治療組和對照組無顯著差異( P gt;0. 05) 。三組血和EBC 中IL-4、IFN-γ含量無顯著差異( P 均 gt;0. 05) 。結論哮喘患者EBC 中NO2 /NO3 含量增高, 吸入糖皮質激素治療后NO2 /NO3 含量降低, 提示哮喘患者在治療前氣道存在明顯的氧化應激。EBC 中L-4 和IFN-γ含量無顯著變化, 能否用于反映哮喘患者的炎癥狀態有待進一步研究

引用本文： 陳燕文,何權瀛,尚穎,改軍. 哮喘患者呼出氣冷凝液中硝酸鹽/ 亞硝酸鹽、白細胞介素4 和γ干擾素檢測的臨床意義. 中國呼吸與危重監護雜志, 2009, 09(2): 131-134. doi: 復制

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9.	Leung TF, Wong GW, Ko FW, et al. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol, 2005, 137: 66-72.
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1. Jeffery PK, Laitinen A, Venge P. Biopsy markers of airway inflammation and remodeling. Respir Med, 2000, 94( suppl F) : S9-S15.
2. Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers, 2002, 7: 1 -32 .
3. American Thoracic Society. Standardization of spirometry 1994. Am J Respir Crit Care Med, 1995, 152: 1107-1136.
4. Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med, 2000, 162: 1273-1276.
5. Corradi M, Pesci A, Casana R, et al. Nitrate in exhaled breath condensate of patients with different airway diseases. Nitric Oxide,2003, 8: 26-30.
6. Formanek W, Inci D, Lauener RP, et al. Elevated nitrite in breath condensate of children with respiratory disease. Eur Respir J, 2002 ,19: 487-491.
7. Ganas K, Loukides S, Papatheodorou G, et al. Total nitrite/ nitrate in expired breath condensate of patients with asthma. Respir Med, 2001, 95: 649-654.
8. Shahid SK, Kharitonov SV, Wilson NM, et al. Increases interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med, 2002, 165 : 1290 -1293.
9. Leung TF, Wong GW, Ko FW, et al. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol, 2005, 137: 66-72.
10. Carpagnano GE, Foschino Barbaro MP, Resta O, et al. Exhaled markers in the monitoring of airways inflammation and its response to steroid’s treatment in mild persistent asthma. Eur J Pharmacol,2005, 519: 175-181.

《中國呼吸與危重監護雜志》

哮喘患者呼出氣冷凝液中硝酸鹽/ 亞硝酸鹽、白細胞介素4 和γ干擾素檢測的臨床意義

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哮喘患者呼出氣冷凝液中硝酸鹽/ 亞硝酸鹽、白細胞介素4 和γ干擾素檢測的臨床意義

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