急性肺損傷/急性呼吸窘迫綜合征預后評估指標研究進展_《中國呼吸與危重監護雜志》

作者：

陳成 , 黃建安

蘇州大學附屬第一醫院呼吸內科（江蘇蘇州 215006）;

關鍵詞：

急性肺損傷/急性呼吸窘迫綜合征

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急性肺損傷（ALI）和急性呼吸窘迫綜合征（ARDS）是指由心源性以外的各種肺內外致病因素所導致的急性進行性缺氧性呼吸衰竭，它們具有性質相同的病理生理改變，嚴重的ALI或ALI的最終嚴重階段被定義為ARDS，臨床表現以呼吸窘迫、頑固性低氧血癥和非心源性肺水腫為特征，采用常規的治療難以糾正其低氧血癥，死亡率高達60%。目前，有關ALI/ARDS的研究取得較多進展，其中，能有效評估ALI病情和預測死亡率的臨床參數和生化指標一直是研究熱點。

引用本文： 陳成,黃建安. 急性肺損傷/急性呼吸窘迫綜合征預后評估指標研究進展. 中國呼吸與危重監護雜志, 2008, 08(2): 156-160. doi: 復制

1.	陸月明,顧秀蓮.急性呼吸窘迫綜合征研究進展.中華流行病學雜志,2005,26:463-465.
2.	García-González MJ, Domínguez-Rodríguez A, Ferrer-Hita JJ.Unusual etiology of acute lung injury in a patient with acute myocardial infarction.Int J Cardiol,2007,117:e95-97.
3.	Ware LB.Prognostic determinants of acute respiratory distress syndrome in adults:impact on clinical trial design.Crit Care Med,2005 ,33:S217-222.
4.	Kondili E,Xirouchaki N,Vaporidi K,et al.Short-term cardiorespiratory effects of proportional assist and pressure-support ventilation in patients with acute lung injury/acute respiratory distress syndrome.Anesthesiology,2006,105:703-708.
5.	Frutos-Vivar F,Nin N,Esteban A.Epidemiology of acute lung injury and acute respiratory distress syndrome.Curr Opin Crit Care,2004,10:1-6.
6.	Rubenfeld GD,Herridge MS.Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,163:1376-1383.
7.	Ware LB,Matthay MA.Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,163:1376-1383.
8.	Calandra T,Roger T.Macrophage migration inhibitory factor:a regulator of innate immunity.Nat Rev Immunol,2003:791-800.
9.	Madtes DK,Rubenfeld G,Klima LD,et al.Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med,1998,158:424-430.
10.	Steinberg KP,Hudson LD,Goodman RB,et al.Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.N Engl J Med,2006,354:1671-1684.
11.	Ware LB,Eisner MD,Thompson BT,et al.Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med,2004,170:766-772.
12.	Eisner MD,Parsons P,Matthay MA, et al.Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury.Thorax,2003,58:983-988.
13.	Sorensen GL,Husby S,Holmskov U,et al.Surfactant protein A and surfactant protein D variation in pulmonary disease.Immunobiology,2007,212,381-416.
14.	Sato H,Callister ME,Mumby S,et al.KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome.Eur Respir J,2004,23:142-145.
15.	Lang JD,McArdle PJ,O’Reilly PJ,et al.Oxidant-antioxidant balance in acute lung injury.Chest,2002,122:314S-320S.
16.	Marshall RP,Bellingan G,Webb S,et al.Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome.Am J Respir Crit Care Med,2000,162:1783-1788.
17.	Clark JG,Milberg JA,Steinberg KP,et al.Type III procollagen peptide in the adult respiratory distress syndrome.Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death.Ann Intern Med,1995,122:17-23.
18.	Chesnutt AN,Matthay MA,Tibayan FA,et al.Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.Am J Respir Crit Care Med,1997,156:840-845.
19.	Goodman RB,Pugin J,Lee JS,et al.Cytokine-mediated inflammation in acute lung injury.Cytokine Growth Factor Rev,2003,14:523-535.
20.	Imamura S,Matsukawa A,Ohkawara S,et al.Involvement of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-8,and interleukin-1 receptor antagonist in acute lung injury caused by local Shwartzman reaction.Pathol Int,1997,47:16-24.
21.	李洪霞,張進川,趙亞力,等.急性肺損傷大鼠TNF-α、IL-1β、IL-1ra mRNA的表達及藥物干預.解放軍醫學雜志,2005,30:306-309.
22.	Parsons PE,Matthay MA,Ware LB,et al.Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.Am J Physiol Lung Cell Mol Physiol,2005,288:L426-431.
23.	Pugin J,Ricou B,Steinberg KP,et al.Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS,a prominent role for interleukin-1.Am J Respir Crit Care Med,1996,153:1850-1856.
24.	Olman MA,White KE,Ware LB,et al.Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.J Immunol,2004,172:2668-2677.
25.	Tzouvelekis A,Pneumatikos I,Bouros D.Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator.Respir Res,2005,6:62.
26.	Parsons PE,Eisner MD,Thompson BT,et al.Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.Crit Care Med,2005,33:1-6.
27.	Stüber F,Wrigge H,Schroeder S,et al.Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury.Intensive Care Med,2002,28:834-841.
28.	Riffo-Vasquez Y,Spina D.Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation. Pharmacol Ther,2002,94:185-211.
29.	Hirose M,Murai T,Kawashima H.Elevation of rat plasma P-selectin in acute lung injury.Biochim Biophys Acta,2007,1772:382-389.
30.	Park WY,Goodman RB,Steinberg KP,et al.Cytokine balance in the lungs of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,164:1896-1903.
31.	Moraes TJ,Chow CW,Downey GP.Proteases and lung injury.Crit Care Med,2003,31:S189-194.
32.	Pugin J,Verghese G,Widmer MC,et al.The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.Crit Care Med,1999,27:304-312.
33.	Kim DK,Fukuda T,Thompson BT,et al.Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome.Am J Physiol,1995,269:L109-118.
34.	Amat M,Barcons M, Mancebo J,et al.Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome:mortality prognostic study.Crit Care Med,2000,28:57-62.
35.	Nuckton TJ,Alonso JA,Kallet RH,et al.Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.N Engl J Med,2002,346:1281-1286.
36.	Abraham E.Coagulation abnormalities in acute lung injury and sepsis.Am J Respir Cell Mol Biol,2000:401-404.
37.	Prabhakaran P,Ware LB,White KE,et al.Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.Am J Physiol,Lung Cell Mol Physiol,2003,285:20-28.
38.	Matthay MA,Ware LB.Plasma protein C levels in patients with acute lung injury: prognostic significance.Crit Care Med,2004,32:S229-S232.
39.	郭強,黃建安,金鈞,等.急性呼吸窘迫綜合征患者早期脂蛋白和凝血指標水平的臨床意義.中國危重病急救醫學,2006,18:380-381.

1. 陸月明,顧秀蓮.急性呼吸窘迫綜合征研究進展.中華流行病學雜志,2005,26:463-465.
2. García-González MJ, Domínguez-Rodríguez A, Ferrer-Hita JJ.Unusual etiology of acute lung injury in a patient with acute myocardial infarction.Int J Cardiol,2007,117:e95-97.
3. Ware LB.Prognostic determinants of acute respiratory distress syndrome in adults:impact on clinical trial design.Crit Care Med,2005 ,33:S217-222.
4. Kondili E,Xirouchaki N,Vaporidi K,et al.Short-term cardiorespiratory effects of proportional assist and pressure-support ventilation in patients with acute lung injury/acute respiratory distress syndrome.Anesthesiology,2006,105:703-708.
5. Frutos-Vivar F,Nin N,Esteban A.Epidemiology of acute lung injury and acute respiratory distress syndrome.Curr Opin Crit Care,2004,10:1-6.
6. Rubenfeld GD,Herridge MS.Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,163:1376-1383.
7. Ware LB,Matthay MA.Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,163:1376-1383.
8. Calandra T,Roger T.Macrophage migration inhibitory factor:a regulator of innate immunity.Nat Rev Immunol,2003:791-800.
9. Madtes DK,Rubenfeld G,Klima LD,et al.Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med,1998,158:424-430.
10. Steinberg KP,Hudson LD,Goodman RB,et al.Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.N Engl J Med,2006,354:1671-1684.
11. Ware LB,Eisner MD,Thompson BT,et al.Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med,2004,170:766-772.
12. Eisner MD,Parsons P,Matthay MA, et al.Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury.Thorax,2003,58:983-988.
13. Sorensen GL,Husby S,Holmskov U,et al.Surfactant protein A and surfactant protein D variation in pulmonary disease.Immunobiology,2007,212,381-416.
14. Sato H,Callister ME,Mumby S,et al.KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome.Eur Respir J,2004,23:142-145.
15. Lang JD,McArdle PJ,O’Reilly PJ,et al.Oxidant-antioxidant balance in acute lung injury.Chest,2002,122:314S-320S.
16. Marshall RP,Bellingan G,Webb S,et al.Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome.Am J Respir Crit Care Med,2000,162:1783-1788.
17. Clark JG,Milberg JA,Steinberg KP,et al.Type III procollagen peptide in the adult respiratory distress syndrome.Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death.Ann Intern Med,1995,122:17-23.
18. Chesnutt AN,Matthay MA,Tibayan FA,et al.Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.Am J Respir Crit Care Med,1997,156:840-845.
19. Goodman RB,Pugin J,Lee JS,et al.Cytokine-mediated inflammation in acute lung injury.Cytokine Growth Factor Rev,2003,14:523-535.
20. Imamura S,Matsukawa A,Ohkawara S,et al.Involvement of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-8,and interleukin-1 receptor antagonist in acute lung injury caused by local Shwartzman reaction.Pathol Int,1997,47:16-24.
21. 李洪霞,張進川,趙亞力,等.急性肺損傷大鼠TNF-α、IL-1β、IL-1ra mRNA的表達及藥物干預.解放軍醫學雜志,2005,30:306-309.
22. Parsons PE,Matthay MA,Ware LB,et al.Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.Am J Physiol Lung Cell Mol Physiol,2005,288:L426-431.
23. Pugin J,Ricou B,Steinberg KP,et al.Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS,a prominent role for interleukin-1.Am J Respir Crit Care Med,1996,153:1850-1856.
24. Olman MA,White KE,Ware LB,et al.Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.J Immunol,2004,172:2668-2677.
25. Tzouvelekis A,Pneumatikos I,Bouros D.Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator.Respir Res,2005,6:62.
26. Parsons PE,Eisner MD,Thompson BT,et al.Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.Crit Care Med,2005,33:1-6.
27. Stüber F,Wrigge H,Schroeder S,et al.Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury.Intensive Care Med,2002,28:834-841.
28. Riffo-Vasquez Y,Spina D.Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation. Pharmacol Ther,2002,94:185-211.
29. Hirose M,Murai T,Kawashima H.Elevation of rat plasma P-selectin in acute lung injury.Biochim Biophys Acta,2007,1772:382-389.
30. Park WY,Goodman RB,Steinberg KP,et al.Cytokine balance in the lungs of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med,2001,164:1896-1903.
31. Moraes TJ,Chow CW,Downey GP.Proteases and lung injury.Crit Care Med,2003,31:S189-194.
32. Pugin J,Verghese G,Widmer MC,et al.The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.Crit Care Med,1999,27:304-312.
33. Kim DK,Fukuda T,Thompson BT,et al.Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome.Am J Physiol,1995,269:L109-118.
34. Amat M,Barcons M, Mancebo J,et al.Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome:mortality prognostic study.Crit Care Med,2000,28:57-62.
35. Nuckton TJ,Alonso JA,Kallet RH,et al.Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.N Engl J Med,2002,346:1281-1286.
36. Abraham E.Coagulation abnormalities in acute lung injury and sepsis.Am J Respir Cell Mol Biol,2000:401-404.
37. Prabhakaran P,Ware LB,White KE,et al.Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.Am J Physiol,Lung Cell Mol Physiol,2003,285:20-28.
38. Matthay MA,Ware LB.Plasma protein C levels in patients with acute lung injury: prognostic significance.Crit Care Med,2004,32:S229-S232.
39. 郭強,黃建安,金鈞,等.急性呼吸窘迫綜合征患者早期脂蛋白和凝血指標水平的臨床意義.中國危重病急救醫學,2006,18:380-381.

《中國呼吸與危重監護雜志》

急性肺損傷/急性呼吸窘迫綜合征預后評估指標研究進展

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《中國呼吸與危重監護雜志》

急性肺損傷/急性呼吸窘迫綜合征預后評估指標研究進展

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