肺炎短程治療_《中國呼吸與危重監護雜志》

作者：

姜紅妮 ¹ ,  瞿介明 ²

1復旦大學附屬中山醫院呼吸內科;;
2復旦大學附屬華東醫院呼吸內科;

關鍵詞：

肺炎短程治療

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細菌耐藥是一個全球性的難題，而濫用抗生素是導致細菌耐藥的重要原因。合理使用抗生素的核心包括以下三點：①選擇合適的抗生素（有效、經濟、毒副作用小和使用方便）；②采取合適的給藥方法（給藥劑量、間期和途徑）；③采取合適的療程。其中抗生素的療程究竟多長最合適是目前研究最薄弱的環節，同時也是當前和今后抗感染領域研究的熱點[1]。

引用本文： 姜紅妮 ,瞿介明. 肺炎短程治療. 中國呼吸與危重監護雜志, 2008, 08(1): 6-8. doi: 復制

1.	何禮賢.值得研究和借鑒的短程抗菌治療策略.中國抗感染化療雜志，2005，5：318-319.
2.	Mandell LA.Update on community-acquired pneumonia.New pathogens and new concepts in treatment.Postgrad Med，2005，118：35-46.
3.	Schwartz DN，Furumoto-Dawson A，Itokazu GS，et al.Preventing mismanagement of community-acquired pneumonia at an urban public hospital：implications for institution-specific practice guidelines.Chest，1998，113（Suppl 3）：194S-198S.
4.	Mandell LA，Wunderink RG，Anzueto A，et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults.Clin Infect Dis，2007，44（Suppl 2）：S27-S72.
5.	American Thoracic Society；Infectious Diseases Society of America.Guidelines for the management of adults with hospital-acquired，ventilator-associated，and healthcare-associated pneumonia.Am J Respir Crit Care Med，2005，171：388-416.
6.	Hospital-acquired pneumonia in adults：diagnosis，assessment of severity，initial antimicrobial therapy，and preventive strategies.A consensus statement，American Thoracic Society，November 1995.Am J Respir Crit Care Med，1996，153：1711-1725.
7.	Woodhead M，Blasi F，Ewig S，et al.Guidelines for the management of adult lower respiratory tract infections.Eur Respir J，2005，26：1138-1180.
8.	Owens RC Jr，Ambrose PG，Nightingale CH.Antibiotic Optimization.Concepts and Strategies in Clinical Practice.New York：Marced Dekker，2005，491-518.
9.	El Moussaoui R，de Borgie CA，van den Broek P，et al.Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia：randomised，double blind study.BMJ，2006，332：1355.
10.	D’Ignazio J，Camere MA，Lewis DE，et al.Novel，single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.Antimicrob Agents Chemother，2005，49：4035-4041.
11.	Tellier G，Niederman MS，Nusrat R，et al.Clinical and bacteriological efficacy and safety of 5 and 7 day regimens of telithromycin once daily compared with a 10 day regimen of clarithromycin twice daily in patients with mild to moderate community-acquired pneumonia.J Antimicrob Chemother，2004，54：515-523.
12.	Dunbar LM，Wunderink RG，Habib MP，et al.High-dose，short-course levofloxacin for community-acquired pneumonia：a new treatment paradigm.Clin Infect Dis，2003，37：752-760.
13.	Dennesen PJ，van der Ven AJ，Kessels AG，et al.Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia.Am J Respir Crit Care Med，2001，163：1371-1375.
14.	Chastre J，Wolff M，Fagon JY，et al.Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults：a randomized trial.JAMA，2003，290：2588-2598.
15.	Parienti JJ，Ramakers M，Charbonneau P，et al.Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit.Am J Respir Crit Care Med，2001，164：172-173.
16.	Zinner SH，Young LS，Acar JF，et al.Expanding indications for the new macrolides，azalides and streptogramins.New York：Marcel Dekker，1997，27-38.
17.	Meehan TP，Fine MJ，Krumholz HM，et al.Quality of care，process，and outcomes in elderly patients with pneumonia.JAMA，1997，278：2080-2084.
18.	Houck PM，Bratzler DW，Nsa W，et al.Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia.Arch Intern Med，2004，164：637-644.

1. 何禮賢.值得研究和借鑒的短程抗菌治療策略.中國抗感染化療雜志，2005，5：318-319.
2. Mandell LA.Update on community-acquired pneumonia.New pathogens and new concepts in treatment.Postgrad Med，2005，118：35-46.
3. Schwartz DN，Furumoto-Dawson A，Itokazu GS，et al.Preventing mismanagement of community-acquired pneumonia at an urban public hospital：implications for institution-specific practice guidelines.Chest，1998，113（Suppl 3）：194S-198S.
4. Mandell LA，Wunderink RG，Anzueto A，et al.Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults.Clin Infect Dis，2007，44（Suppl 2）：S27-S72.
5. American Thoracic Society；Infectious Diseases Society of America.Guidelines for the management of adults with hospital-acquired，ventilator-associated，and healthcare-associated pneumonia.Am J Respir Crit Care Med，2005，171：388-416.
6. Hospital-acquired pneumonia in adults：diagnosis，assessment of severity，initial antimicrobial therapy，and preventive strategies.A consensus statement，American Thoracic Society，November 1995.Am J Respir Crit Care Med，1996，153：1711-1725.
7. Woodhead M，Blasi F，Ewig S，et al.Guidelines for the management of adult lower respiratory tract infections.Eur Respir J，2005，26：1138-1180.
8. Owens RC Jr，Ambrose PG，Nightingale CH.Antibiotic Optimization.Concepts and Strategies in Clinical Practice.New York：Marced Dekker，2005，491-518.
9. El Moussaoui R，de Borgie CA，van den Broek P，et al.Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia：randomised，double blind study.BMJ，2006，332：1355.
10. D’Ignazio J，Camere MA，Lewis DE，et al.Novel，single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.Antimicrob Agents Chemother，2005，49：4035-4041.
11. Tellier G，Niederman MS，Nusrat R，et al.Clinical and bacteriological efficacy and safety of 5 and 7 day regimens of telithromycin once daily compared with a 10 day regimen of clarithromycin twice daily in patients with mild to moderate community-acquired pneumonia.J Antimicrob Chemother，2004，54：515-523.
12. Dunbar LM，Wunderink RG，Habib MP，et al.High-dose，short-course levofloxacin for community-acquired pneumonia：a new treatment paradigm.Clin Infect Dis，2003，37：752-760.
13. Dennesen PJ，van der Ven AJ，Kessels AG，et al.Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia.Am J Respir Crit Care Med，2001，163：1371-1375.
14. Chastre J，Wolff M，Fagon JY，et al.Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults：a randomized trial.JAMA，2003，290：2588-2598.
15. Parienti JJ，Ramakers M，Charbonneau P，et al.Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit.Am J Respir Crit Care Med，2001，164：172-173.
16. Zinner SH，Young LS，Acar JF，et al.Expanding indications for the new macrolides，azalides and streptogramins.New York：Marcel Dekker，1997，27-38.
17. Meehan TP，Fine MJ，Krumholz HM，et al.Quality of care，process，and outcomes in elderly patients with pneumonia.JAMA，1997，278：2080-2084.
18. Houck PM，Bratzler DW，Nsa W，et al.Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia.Arch Intern Med，2004，164：637-644.

《中國呼吸與危重監護雜志》

肺炎短程治療

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《中國呼吸與危重監護雜志》

肺炎短程治療

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