抑癌基因失活在多原發性惡性腫瘤發生中的意義_《中國普外基礎與臨床雜志》

作者：

張毅綜述姜軍審校

第三軍醫大學西南醫院普外科(重慶400038);

關鍵詞：

抑癌基因多原發性惡性腫瘤腫瘤發生

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的探討抑癌基因在多原發性惡性腫瘤(MPMN)發生中的重要作用。
方法采用回顧性分析的方法對近年來多原發性惡性腫瘤中常見的相關抑癌基因研究進行了綜述。
結果目前在多原發性惡性腫瘤研究中，研究較多的抑癌基因有p53、APC、p16、BRCA1、BRCA2、PTEN/MMAC1等基因，許多MPMN可檢測出相同的抑癌基因突變。
結論多原發性惡性腫瘤發生與抑癌基因失活有重要關系，通過對抑癌基因在MPMN中作用的研究，可揭示出MPMN發生的某些共同規律。

引用本文： 張毅綜述姜軍審校. 抑癌基因失活在多原發性惡性腫瘤發生中的意義. 中國普外基礎與臨床雜志, 2000, 7(6): 418-420. doi: 復制

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13.	Durocher F, Tonin P, Shattuck ED, et al. Mutation analysis of the BRCA1 gene in 23 families with cancers of the breast ovary and multiple other sites 〔Ｊ〕. J Med Genet, 1996; 33(11)∶814.
14.	Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
15.	Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
16.	Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
17.	Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
18.	Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
19.	Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
20.	Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
21.	Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
22.	Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
23.	Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
24.	Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
25.	Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.

1. Miki Y, Swensen J, Shattuck K, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 〔Ｊ〕. Science, 1994; 266(5188)∶66.
2. Sinicrope FA, Rvan SB, Cleary RR, et al. Bcl2 and p53 oncoprotein expression during colorectal tumorigenes 〔Ｊ〕. Cancer Res, 1995; 55(2)∶237.
3. Harris CG. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies 〔Ｊ〕. J Natl Cancer Inst, 1996; 88(20)∶1442.
4. Mitsudomi T, Yatabe Y, Kosshikawa T, et al. Mutations of the p53 tumor suppressor gene as clonal marker for multiple primary lung cancers 〔Ｊ〕. J Thorac Cardiovasc Surg, 1997; 114(3)∶354.
5. Hisada M, Garber JE, Fung CY, et al. Multiple primary cancers in families with LiFraumeni syndrome 〔Ｊ〕. J Notl Cancer Inst, 1998; 90(8)∶606.
6. Alconchel MD, Olivares C, Alvarez R, et al. Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars 〔Ｊ〕. Br J Dermatol, 1997; 137(5)∶793.
7. Sparks AB, Morin PJ, Vogolstegn B, et al. Mutational analuyusis of the APC/βcatenin/TCF pathway in colorectal cancer 〔Ｊ〕. Cancer Res, 1998; (6)∶1130.
8. Mahmoud NN, Boolbol SK, Bilinski RT, et al. APC gene mutations is assoceated with a dominantnegative effect up intestinal cell migration 〔Ｊ〕. Cancer Res, 1997; 57(22)∶5045.
9. Milner J, Ponder B, Davies L, et al. Transcriptional activation 〔Ｊ〕. Nature, 1997; 386(6626)∶772.
10. Gorden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene 〔Ｊ〕. Cell, 1991; 66(3)∶589.
11. Winchester DP. Breast cancer in young women 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶279.
12. Easton DF, Bishop DT, Ford D, et al. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families 〔Ｊ〕. Am J Hum Genet, 1993; 52(4)∶678.
13. Durocher F, Tonin P, Shattuck ED, et al. Mutation analysis of the BRCA1 gene in 23 families with cancers of the breast ovary and multiple other sites 〔Ｊ〕. J Med Genet, 1996; 33(11)∶814.
14. Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
15. Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
16. Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
17. Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
18. Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
19. Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
20. Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
21. Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
22. Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
23. Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
24. Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
25. Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.

《中國普外基礎與臨床雜志》

抑癌基因失活在多原發性惡性腫瘤發生中的意義

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《中國普外基礎與臨床雜志》

抑癌基因失活在多原發性惡性腫瘤發生中的意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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