Alu重復序列的特性及其與惡性腫瘤的關系_《中國普外基礎與臨床雜志》

作者：

王俊鋒 ¹ , 周總光 ¹ , 陳堯 ²

1.四川大學華西醫院消化外科實驗室（成都610041）;;
2.四川大學華西醫學中心基礎與法醫學院解剖實驗室（成都610041）;

關鍵詞：

Alu序列惡性腫瘤同源重組短分散序列

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【摘要】目的探討Alu重復序列的結構特性及其與惡性腫瘤的關系。
方法復習近年來有關Alu重復序列在分子生物學及腫瘤學方面的研究結果。
結果 Alu序列之間的同源重組可導致基因缺失、重復，染色體移位導致基因重排，從而使某些癌基因活化,導致一系列的惡性改變。
結論 Alu序列是一種多功能的調控序列，在一些腫瘤的發生、發展中起重要作用。

引用本文： 王俊鋒,周總光,陳堯. Alu重復序列的特性及其與惡性腫瘤的關系. 中國普外基礎與臨床雜志, 2005, 12(4): 419-421. doi: 復制

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11.	Rudiger NS, Gregersen N, KiellandBrandt MC. One short well conserved region of Alusequences is involved in human gene rearrangements and has homology with prokaryotic chi [J]. Nucleic Acids Res, 1995; 23(2)∶256).
12.	Jeffs AR, Benjes SM, Smith TL, et al. The BCR gene recombines preferentially with Alu elements in complex BCRABL translocations of chronic myeloid leukaemia [J]. Hum Mol Genet, 1998; 7(5)∶767.
13.	Aoki K, Suzuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations [J]. Nat Genet, 1995; 10(2)∶167.
14.	Kato S, Anderson RA, CameriniOtero RD. Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome [J]. Mol Cell Biol, 1986; 6(5)∶1787.
15.	Jurka J, Milosavljevic A. Reconstruction and analysis of human Alu genes [J]. J Mol Evol, 1991; 32(2)∶105.
16.	Rohlfs EM, Puget N, Graham ML, et al. An Alumediated 7.1 kb deletion of BRCA1 exons 8 and 9 in breast and ovarian cancer families that results in alternative splicing of exon 10 [J]. Genes Chromosomes Cancer, 2000; 28(3)∶300.
17.	Tournier I, Paillerets BB, Sobol H, et al. Significant contribution of germline BRCA2 rearrangements in male breast cancer families [J]. Cancer Res, 2004; 64(22)∶8143.
18.	Ichimura K, Hanafusa H, Takimoto H, et al. Structure of the human retinoblastomarelated p107 gene and its intragenic deletion in a Bcell lymphoma cell line [J]. Gene, 2000; 251(1)∶37.
19.	Wang Y, Friedl W, Lamberti C, et al. Hereditary nonpolyposis colorectal cancer: frequent occurrence of large genomic deletions in MSH2 and MLH1 genes [J]. Int J Cancer, 2003; 103(5)∶636.
20.	Hsieh SY, Liaw SF, Lee SN, et al. Aberrant caspaseactivated DNase (CAD) transcripts in human hepatoma cells [J]. Br J Cancer, 2003; 88(2)∶210.
21.	Strout MP, Marcucci G, Bloomfield CD, et al. The partial tandem duplication of ALL1 (MLL) is consistently generated by Alumediated homologous recombination in acute myeloid leukemia [J]. Proc Natl Acad Sci USA, 1998; 95(5)∶2390.

1. Houck CM, Rinehart FP, Schmid CW. A ubiquitous family of repeated DNA sequences in the human genome [J]. J Mol Biol， 1979; 132(3)∶289.
2. Deininger PL, Batzer MA. Alu repeats and human disease [J]. Mol Genet Metab, 1999; 67(3)∶183.
3. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome [J]. Nature, 2001; 409(6822)∶860.
4. Batzer MA, Kilroy GE, Richard PE, et al. Structure and variability of recently inserted Alu family members [J]. Nucleic Acids Res, 1990; 18(23)∶6793.
5. Mighell AJ, Markham AF, Robinson PA. Alu sequences [J]. FEBS Lett, 1997; 417(1)∶1.
6. Boeke JD. LINEs and Alus——the polyA connection [J]. Nat Genet, 1997; 16(1)∶6.
7. Fanning TG, Singer MF. LINE1: a mammalian transposable element [J]. Biochim Biophys Acta, 1987; 910(3)∶203.
8. Skowronski J, Singer MF. The abundant LINE1 family of repeated DNA sequences in mammals: genes and pseudogenes [J]. Cold Spring Harb Symp Quant Biol, 1986; 51 Pt 1∶457.
9. Batzer MA, Deininger PL. Alu repeats and human genomic diversity [J]. Nat Rev Genet, 2002; 3(5)∶370.
10. Shih C, Weinberg RA. Isolation of a transforming sequence from a human bladder carcinoma cell line [J]. Cell, 1982; 29(1)∶161).
11. Rudiger NS, Gregersen N, KiellandBrandt MC. One short well conserved region of Alusequences is involved in human gene rearrangements and has homology with prokaryotic chi [J]. Nucleic Acids Res, 1995; 23(2)∶256).
12. Jeffs AR, Benjes SM, Smith TL, et al. The BCR gene recombines preferentially with Alu elements in complex BCRABL translocations of chronic myeloid leukaemia [J]. Hum Mol Genet, 1998; 7(5)∶767.
13. Aoki K, Suzuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations [J]. Nat Genet, 1995; 10(2)∶167.
14. Kato S, Anderson RA, CameriniOtero RD. Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome [J]. Mol Cell Biol, 1986; 6(5)∶1787.
15. Jurka J, Milosavljevic A. Reconstruction and analysis of human Alu genes [J]. J Mol Evol, 1991; 32(2)∶105.
16. Rohlfs EM, Puget N, Graham ML, et al. An Alumediated 7.1 kb deletion of BRCA1 exons 8 and 9 in breast and ovarian cancer families that results in alternative splicing of exon 10 [J]. Genes Chromosomes Cancer, 2000; 28(3)∶300.
17. Tournier I, Paillerets BB, Sobol H, et al. Significant contribution of germline BRCA2 rearrangements in male breast cancer families [J]. Cancer Res, 2004; 64(22)∶8143.
18. Ichimura K, Hanafusa H, Takimoto H, et al. Structure of the human retinoblastomarelated p107 gene and its intragenic deletion in a Bcell lymphoma cell line [J]. Gene, 2000; 251(1)∶37.
19. Wang Y, Friedl W, Lamberti C, et al. Hereditary nonpolyposis colorectal cancer: frequent occurrence of large genomic deletions in MSH2 and MLH1 genes [J]. Int J Cancer, 2003; 103(5)∶636.
20. Hsieh SY, Liaw SF, Lee SN, et al. Aberrant caspaseactivated DNase (CAD) transcripts in human hepatoma cells [J]. Br J Cancer, 2003; 88(2)∶210.
21. Strout MP, Marcucci G, Bloomfield CD, et al. The partial tandem duplication of ALL1 (MLL) is consistently generated by Alumediated homologous recombination in acute myeloid leukemia [J]. Proc Natl Acad Sci USA, 1998; 95(5)∶2390.

《中國普外基礎與臨床雜志》

Alu重復序列的特性及其與惡性腫瘤的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

Alu重復序列的特性及其與惡性腫瘤的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料