應激狀態下腸屏障功能的變化及其機理的研究進展_《中國普外基礎與臨床雜志》

作者：

孫敬平 , 馬洪升

四川大學華西醫院消化內科（成都610041）;

關鍵詞：

應激腸屏障功能發病機理

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】目的綜述應激狀態下腸屏障功能的變化及其機理的研究進展。
方法對近年來的相關文獻進行分析。
結果機體在創傷、嚴重感染、大手術和重癥胰腺炎等嚴重應激狀態下，其腸屏障功能將發生一系列病理生理的變化，甚至導致全身炎癥反應綜合征和多器官功能障礙綜合征或多器官功能衰竭，其變化機理是一系列神經、免疫、內分泌機理相互作用的結果。
結論認識應激狀態下腸屏障功能的變化及其機理對臨床上治療應激引起的腸功能紊亂以及預防由此所誘發的嚴重并發癥具有重要的臨床意義。

引用本文： 孫敬平,馬洪升. 應激狀態下腸屏障功能的變化及其機理的研究進展. 中國普外基礎與臨床雜志, 2005, 12(3): 314-316. doi: 復制

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5.	Saunders PR, Kosecka U, McKay DM, et al. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine [J]. Am J Physiol, 1994; 267(5 Pt 1)∶G794.
6.	Castagliuolo I, Lamont JT, Qiu B, et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells [J]. Am J Physiol, 1996; 271(5 Pt 1)∶G884.
7.	Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure [J]. Arch Surg, 1990; 125(3)∶403.
8.	Barclay GR, Turnberg LA. Effect of psychological stress on salt and water transport in the human jejunum [J]. Gastroenterology, 1987; 93(1)∶91.
9.	Wilson LM, Baldwin AL. Environmental stress causes mast cell degranulation, endothelial and epithelial changes, and edema in the rat intestinal mucosa [J]. Microcirculation, 1999; 6(3)∶189.
10.	Castagliuolo I, Wershil BK, Karalis K, et al. Colonic mucin release in response to immobilization stress is mast cell dependent [J]. Am J Physiol, 1998; 274(6 Pt 1)∶G1094.
11.	Saunders PR, Santos J, Hanssen NP, et al. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH [J]. Dig Dis Sci, 2002; 47(1)∶208.
12.	Alptekin N, Seckin S, DogruAbbasoglu S, et al. Lipid peroxides, glutathione, gammaglutamylcysteine synthetase and gammaglutamyltranspeptidase activities in several tissues of rats following waterimmersion stress [J]. Pharmacol Res, 1996; 34(3-4)∶167.
13.	Anup R, Aparna V, Pulimood A, et al. Surgical stress and the small intestine: role of oxygen free radicals [J]. Surgery, 1999; 125(5)∶560.
14.	Li LS, Qu RY, Wang W, et al. Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats [J]. World J Gastroenterol, 2003; 9(3)∶553.
15.	Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction [J]. Am J Physiol, 1996; 270(2 Pt 1)∶G225.
16.	Papaconstantinou HT, Chung DH, Zhang W, et al. Prevention of mucosal atrophy: role of glutamine and caspases in apoptosis in intestinal epithelial cells [J]. J Gastrointest Surg, 2000; 4(4)∶416.

1. Soderholm JD, Perdue MH. Stress and gastrointestinal tract. II. Stress and intestinal barrier function [J]. Am J Physiol Gastrointest Liver Physiol， 2001; 280(1)∶G7.
2. Madara JL. Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions [J]. J Membr Biol, 1990; 116(2)∶177.
3. Meddings JB, Swain MG. Environmental stressinduced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat [J]. Gastroenterology, 2000; 119(4)∶1019.
4. Santos J, Saperas E, Mourelle M, et al. Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropinreleasing hormone in rats [J]. Gastroenterology, 1996; 111(6)∶1465.
5. Saunders PR, Kosecka U, McKay DM, et al. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine [J]. Am J Physiol, 1994; 267(5 Pt 1)∶G794.
6. Castagliuolo I, Lamont JT, Qiu B, et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells [J]. Am J Physiol, 1996; 271(5 Pt 1)∶G884.
7. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure [J]. Arch Surg, 1990; 125(3)∶403.
8. Barclay GR, Turnberg LA. Effect of psychological stress on salt and water transport in the human jejunum [J]. Gastroenterology, 1987; 93(1)∶91.
9. Wilson LM, Baldwin AL. Environmental stress causes mast cell degranulation, endothelial and epithelial changes, and edema in the rat intestinal mucosa [J]. Microcirculation, 1999; 6(3)∶189.
10. Castagliuolo I, Wershil BK, Karalis K, et al. Colonic mucin release in response to immobilization stress is mast cell dependent [J]. Am J Physiol, 1998; 274(6 Pt 1)∶G1094.
11. Saunders PR, Santos J, Hanssen NP, et al. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH [J]. Dig Dis Sci, 2002; 47(1)∶208.
12. Alptekin N, Seckin S, DogruAbbasoglu S, et al. Lipid peroxides, glutathione, gammaglutamylcysteine synthetase and gammaglutamyltranspeptidase activities in several tissues of rats following waterimmersion stress [J]. Pharmacol Res, 1996; 34(3-4)∶167.
13. Anup R, Aparna V, Pulimood A, et al. Surgical stress and the small intestine: role of oxygen free radicals [J]. Surgery, 1999; 125(5)∶560.
14. Li LS, Qu RY, Wang W, et al. Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats [J]. World J Gastroenterol, 2003; 9(3)∶553.
15. Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction [J]. Am J Physiol, 1996; 270(2 Pt 1)∶G225.
16. Papaconstantinou HT, Chung DH, Zhang W, et al. Prevention of mucosal atrophy: role of glutamine and caspases in apoptosis in intestinal epithelial cells [J]. J Gastrointest Surg, 2000; 4(4)∶416.

《中國普外基礎與臨床雜志》

應激狀態下腸屏障功能的變化及其機理的研究進展

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《中國普外基礎與臨床雜志》

應激狀態下腸屏障功能的變化及其機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料