腫瘤抑制基因甲基化與胃癌△_《中國普外基礎與臨床雜志》

作者：

楊少輝 , 戴冬秋

中國醫科大學附屬第一醫院腫瘤外科（沈陽110001）;;
通訊作者：戴冬秋， E-mail： daidq63@163.com;

關鍵詞：

胃癌腫瘤抑制基因甲基化

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目的　探討腫瘤抑制基因甲基化與胃癌的關系。方法　對近年來關于腫瘤抑制基因甲基化與胃癌關系的文獻進行綜述分析。結果　胃癌中，細胞周期調控基因、有絲分裂檢測點基因、凋亡相關基因、錯配修復基因、轉移相關基因等多種腫瘤抑制基因發生甲基化而失活。結論　腫瘤抑制基因甲基化在胃癌的發生、發展過程中起重要作用，腫瘤抑制基因的甲基化有可能成為胃癌診斷、判斷轉移和評價預后的分子標記物，去甲基化干預有望成為胃癌治療的新方法。

引用本文： 楊少輝,戴冬秋. 腫瘤抑制基因甲基化與胃癌△. 中國普外基礎與臨床雜志, 2006, 13(5): 614-616. doi: 復制

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15.	Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
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1. 　Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089.
2. 　Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461.
3. 　Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241.
4. 　Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183.
5. 　Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1.
6. 　Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635.
7. 　Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423.
8. 　Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646.
9. 　Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761.
10. 　Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129.
11. 　Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021.
12. 　Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445.
13. 　Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208.
14. 　Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
15. 　Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
16. 　Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
17. 　鄭志紅，孫秀菊，邱廣蓉，等. 胃癌癌前和發展階段中E-cadherin基因的突變 [J]. 世界華人消化雜志， 2002; 10（2）∶153.
18. 　鄭志紅，孫秀菊，馬鳴超，等. 胃癌發展相關階段中E-cadherin基因啟動子甲基化及蛋白表達的研究 [J]. 遺傳學報， 2003; 30（2）∶103.
19. 　Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573.

《中國普外基礎與臨床雜志》

腫瘤抑制基因甲基化與胃癌△

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《中國普外基礎與臨床雜志》

腫瘤抑制基因甲基化與胃癌△

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料