肝癌自發性破裂機理的研究進展_《中國普外基礎與臨床雜志》

作者：

呂成超 , 朱立新

安徽醫科大學第一附屬醫院普外科(合肥230032);

關鍵詞：

肝癌自發性破裂抗原抗體復合物機理

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目的探討肝癌自發性破裂的機理。
方法采用文獻回顧的方法，對肝癌自發性破裂患者的資料加以綜述。
結果肝癌自發性破裂的患者體內抗原抗體復合物積聚并沉積在小動脈壁彈力膜上，在其沉積處的小動脈壁存在血管受損現象。
結論乙肝病毒感染所形成的抗原抗體復合物沉積在血管壁導致小動脈脆性病變，可能與肝癌自發性破裂出血有關。

引用本文： 呂成超,朱立新. 肝癌自發性破裂機理的研究進展. 中國普外基礎與臨床雜志, 2006, 13(2): 181-183. doi: 復制

1.	Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases [J]. Am J Gastroenterol， 1991; 86(1)∶67.
2.	Chearanai O, Plengvanit U, Asavanich C, et al. Spontaneous rupture of primary hepatoma: report of 63 cases with particular reference to the pathogenesis and rationale treatment by hepatic artery ligation [J]. Cancer， 1983; 51(8)∶1532.
3.	Kew MC, Hodkinson J. Rupture of hepatocellular carcinoma as a result of blunt abdominal trauma [J]. Am J Gastroenterol， 1991; 86(8)∶1083.
4.	Hermann RE, David TE. Spontaneous rupture of the liver caused by hepatomas [J]. Surgery， 1973; 74(5)∶715.
5.	Kanematsu M, Imaeda T, Yamawaki Y, et al. Rupture of hepatocellular carcinoma: predictive value of CT findings [J]. AJR Am J Roentgenol， 1992; 158(6)∶1247.
6.	Nagasue N, Inokuchi K, Kobayashi M, et al. Hepatoportal arteriovenous fistula in primary carcinoma of the liver [J]. Surg Gynecol Obstet， 1977; 145(4)∶504.
7.	Zhu LX, Wang GS, Fan ST. Spontaneous rupture of hepatocellular carcinoma [J]. Br J Surg， 1996; 83(5)∶602.
8.	Zhu LX, Geng XP, Fan ST. Spontaneous rupture of hepatocellular carcinoma and vascular injury [J]. Arch Surg, 2001; 136(6)∶682.
9.	Zhu LX, Liu Y, Fan ST. Ultrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma [J]. Asian J Surg, 2002; 25(2)∶157.
10.	Zhu LX, Meng XL, Fan ST. Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma [J]. Hepatol Res, 2004; 29(1)∶13.
11.	朱立新，耿小平，范上達. 肝癌自發性破裂與抗原抗體復合物的庫管沉積 [J]. 中華肝膽外科雜志， 2001； 7（11）∶674.
12.	Cooper NR Eds. Adv immunol [M]. New York： Hirsch, 1985∶151-216.
13.	Fan PT, Davis JA, Somer T, et al. A clinical approach to systemic vasculitis [J]. Semin Arthritis Rheum, 1980; 9(4)∶248.
14.	Leib ES, Hibrawi H, Chia D, et al. Correlation of disease activity in systemic necrotizing vasculitis with immune complexes [J]. J Rheumatol, 1981; 8(2)∶258.
15.	Assoian RK, Sporn MB. Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells [J]. J Cell Biol, 1986; 102(4)∶1217.
16.	Ross R. Plateletdrived growth factor [J]. Lancet, 1989; 1(8648)∶179.
17.	Cozzolino F, Torcia M, Lucibello M, et al. Interferonalpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth [J]. J Clin Invest, 1993; 91(6)∶2504.
18.	Ghadially FN Eds. Ultrastructure pathology of the cell and matrix [M]. London: Butterworths, 1988∶1099-1129.
19.	Johannessen JV Eds. Electron microscopy in human medicine [M]. New York: McGAWHALL, 1980∶94-154.
20.	Tsuboi R, Sato Y, Rifkin DB. Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells [J]. J Cell Biol, 1990; 110(2)∶511.
21.	James TW, Wagner R, White LA, et al. Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth musclederived cell line [J]. J Cell Physiol, 1993; 157(2)∶426.
22.	Dobrin PB, Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation [J]. Cardiovasc Surg， 1994; 2(4)∶484.
23.	Liu CL, Fan ST, Lo CM, et al. Management of spontaneous rupture of hepatocellular carcinoma: singlecenter experience [J]. J Clin Oncol， 2001; 19(17)∶3725.

1. Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases [J]. Am J Gastroenterol， 1991; 86(1)∶67.
2. Chearanai O, Plengvanit U, Asavanich C, et al. Spontaneous rupture of primary hepatoma: report of 63 cases with particular reference to the pathogenesis and rationale treatment by hepatic artery ligation [J]. Cancer， 1983; 51(8)∶1532.
3. Kew MC, Hodkinson J. Rupture of hepatocellular carcinoma as a result of blunt abdominal trauma [J]. Am J Gastroenterol， 1991; 86(8)∶1083.
4. Hermann RE, David TE. Spontaneous rupture of the liver caused by hepatomas [J]. Surgery， 1973; 74(5)∶715.
5. Kanematsu M, Imaeda T, Yamawaki Y, et al. Rupture of hepatocellular carcinoma: predictive value of CT findings [J]. AJR Am J Roentgenol， 1992; 158(6)∶1247.
6. Nagasue N, Inokuchi K, Kobayashi M, et al. Hepatoportal arteriovenous fistula in primary carcinoma of the liver [J]. Surg Gynecol Obstet， 1977; 145(4)∶504.
7. Zhu LX, Wang GS, Fan ST. Spontaneous rupture of hepatocellular carcinoma [J]. Br J Surg， 1996; 83(5)∶602.
8. Zhu LX, Geng XP, Fan ST. Spontaneous rupture of hepatocellular carcinoma and vascular injury [J]. Arch Surg, 2001; 136(6)∶682.
9. Zhu LX, Liu Y, Fan ST. Ultrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma [J]. Asian J Surg, 2002; 25(2)∶157.
10. Zhu LX, Meng XL, Fan ST. Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma [J]. Hepatol Res, 2004; 29(1)∶13.
11. 朱立新，耿小平，范上達. 肝癌自發性破裂與抗原抗體復合物的庫管沉積 [J]. 中華肝膽外科雜志， 2001； 7（11）∶674.
12. Cooper NR Eds. Adv immunol [M]. New York： Hirsch, 1985∶151-216.
13. Fan PT, Davis JA, Somer T, et al. A clinical approach to systemic vasculitis [J]. Semin Arthritis Rheum, 1980; 9(4)∶248.
14. Leib ES, Hibrawi H, Chia D, et al. Correlation of disease activity in systemic necrotizing vasculitis with immune complexes [J]. J Rheumatol, 1981; 8(2)∶258.
15. Assoian RK, Sporn MB. Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells [J]. J Cell Biol, 1986; 102(4)∶1217.
16. Ross R. Plateletdrived growth factor [J]. Lancet, 1989; 1(8648)∶179.
17. Cozzolino F, Torcia M, Lucibello M, et al. Interferonalpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth [J]. J Clin Invest, 1993; 91(6)∶2504.
18. Ghadially FN Eds. Ultrastructure pathology of the cell and matrix [M]. London: Butterworths, 1988∶1099-1129.
19. Johannessen JV Eds. Electron microscopy in human medicine [M]. New York: McGAWHALL, 1980∶94-154.
20. Tsuboi R, Sato Y, Rifkin DB. Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells [J]. J Cell Biol, 1990; 110(2)∶511.
21. James TW, Wagner R, White LA, et al. Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth musclederived cell line [J]. J Cell Physiol, 1993; 157(2)∶426.
22. Dobrin PB, Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation [J]. Cardiovasc Surg， 1994; 2(4)∶484.
23. Liu CL, Fan ST, Lo CM, et al. Management of spontaneous rupture of hepatocellular carcinoma: singlecenter experience [J]. J Clin Oncol， 2001; 19(17)∶3725.

《中國普外基礎與臨床雜志》

肝癌自發性破裂機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

肝癌自發性破裂機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料