肝移植后肝動脈血栓形成的危險因素及防治措施_《中國普外基礎與臨床雜志》

作者：

王晨宇 , 劉連新 , 姜洪池

哈爾濱醫科大學附屬第一醫院普外科六病房(哈爾濱150001);

關鍵詞：

肝移植肝動脈血栓形成

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　探討肝移植后肝動脈血栓形成的好發因素及其防治措施。
方法　收集國內、外近年來關于肝移植后肝動脈血栓形成的好發因素及防治方面的文獻并作一綜述。
結果　肝移植后肝動脈血栓形成的好發因素有第五因子萊頓、受體的代謝性肝臟疾病和受體的性別、肝移植中Roux-en-Y法膽管重建術的應用、病毒感染等方面；防治措施主要有早期診斷、檢測激活蛋白C抵抗性與預防性應用抗凝劑、改進肝動脈重建的方法、高壓氧療法、經導管持續溶栓治療、再次肝移植等方面。
結論　肝移植后肝動脈血栓形成的好發因素及其防治措施的研究對改善肝移植患者的預后有指導作用。

引用本文： 王晨宇,劉連新,姜洪池. 肝移植后肝動脈血栓形成的危險因素及防治措施. 中國普外基礎與臨床雜志, 2007, 14(5): 615-618. doi: 復制

1.	Washington K. Update on post-liver transplantation infections, malignancies, and surgical complications [J]. Adv Anat Pathol， 2005; 12(4)∶221.
2.	陳煥偉, 甄作均, 蘇樹英, 等. 原位肝移植術后并發癥的診治體會(附16例報告) [J]. 中國普外基礎與臨床雜志, 2004; 11(5)∶163.
3.	Boyvat F, Aytekin C, Firat A, et al. Diagnostic and therapeutic management of hepatic artery thrombosis and stenosis after orthotopic and heterotopic liver transplantation [J]. Transplant Proc， 2003; 35(7)∶2791.
4.	李汛, 李玉民, 石斌, 等. 肝移植術后肝動脈血栓的防治(附2例報告) [J]. 中國普外基礎與臨床雜志, 2005; 12(5)∶511.
5.	Stange BJ, Glanemann M, Nuessler NC, et al. Hepatic artery thrombosis after adult liver transplantation [J]. Liver Transpl， 2003; 9(6)∶612.
6.	Dunn TB, Linden MA, Vercellotti GM, et al. Factor Ⅴ Leiden and hepatic artery thrombosis after liver transplantation [J]. Clin Transplant， 2006; 20(1)∶132.
7.	Jain A, Costa G, Marsh W, et al. Thrombotic and nonthrombotic hepatic artery complications in adults and children following primary liver transplantation with long-term follow-up in 1 000 consecutive patients [J]. Transpl Int， 2006; 19(1)∶27.
8.	Hirshfield G, Collier JD, Brown K, et al. Donor factor Ⅴ Leiden mutation and vascular thrombosis following liver transplantation [J]. Liver Transpl Surg， 1998; 4(1)∶58.
9.	Ikegami T, Hashikura Y, Nakazawa Y, et al. Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation [J]. J Hepatobiliary Pancreat Surg， 2006; 13(2)∶105.
10.	Silva MA, Jambulingam PS, Gunson BK, et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom [J]. Liver Transpl， 2006; 12(1)∶146.
11.	Ishigami K, Zhang Y, Rayhill S, et al. Does variant hepatic artery anatomy in a liver transplant recipient increase the risk of hepatic artery complications after transplantation? [J]. AJR Am J Roentgenol， 2004; 183(6)∶1577.
12.	Drazan K, Shaked A, Olthoff KM, et al. Etiology and management of symptomatic adult hepatic artery thrombosis after orthotopic liver transplantation (OLT) [J]. Am Surg， 1996; 62(3)∶237.
13.	Proposito D, Loinaz Segurola C, Garcia Garcia I, et al. Assessment of risk factors in the incidence of hepatic artery thrombosis in a consecutive series of 687 liver transplantations [J]. Ann Ital Chir， 2001; 72(2)∶187.
14.	Zhou J, Fan J, Wang JH, et al. Continuous transcatheter arterial thrombolysis for early hepatic artery thrombosis after liver transplantation [J]. Transplant Proc， 2005; 37(10)∶4426.
15.	Uzochukwu LN, Bluth EI, Smetherman DH, et al. Early postoperative hepatic sonography as a predictor of vascular and biliary complications in adult orthotopic liver transplant patients [J]. AJR Am J Roentgenol， 2005; 185(6)∶1558.
16.	Kaneko J, Sugawara Y, Akamatsu N, et al. Prediction of hepatic artery thrombosis by protocol Doppler ultrasonography in pediatric living donor liver transplantation [J]. Abdom Imaging， 2004; 29(5)∶603.
17.	Lin M, Crawford M, Fisher J, et al. Hepatic artery thrombosis and intraoperative hepatic artery flow rates in adult orthotopic liver transplantation [J]. ANZ J Surg， 2002; 72(11)∶798.
18.	Kubota K, Kita J, Shimoda M, et al. Intraoperative assessment of reconstructed vessels in living-donor liver transplantation, using a novel fluorescence imaging technique [J]. J Hepatobiliary Pancreat Surg， 2006; 13(2)∶100.
19.	吳剛，劉永鋒，梁鍵，等. 原位肝移植肝動脈血栓形成的預防與治療 [J]. 中華普通外科雜志, 2005; 14(7)∶483.
20.	Matsuda H, Yagi T, Sadamori H, et al. Complications of arterial reconstruction in living donor liver transplantation: a single-center experience [J]. Surg Today， 2006; 36(3)∶245.
21.	Mazariegos GV, O’Toole K, Mieles LA, et al. Hyperbaric oxygen therapy for hepatic artery thrombosis after liver transplantation in children [J]. Liver Transpl Surg， 1999; 5(5)∶429.
22.	Dubost T, Goubaux B, Duhalde M, et al. Use of hyperbaric oxygen for hepatic artery thrombosis following adult orthotopic liver transplantation [J]. Eur J Anaesthesiol， 2002; 19(3)∶223.
23.	Grover I, Conley L, Alzate G, et al. Hyperbaric oxygen therapy for hepatic artery thrombosis following liver transplantation: current concepts [J]. Pediatr Transplant， 2006; 10(2)∶234.
24.	陳規劃, 陸敏強, 蔡常潔, 等. 肝移植手術相關并發癥的防治 [J]. 中華外科雜志, 2006; 44(5)∶295.
25.	李國強, 王學浩, 李相成, 等. 活體肝移植圍手術期處理 [J]. 中國普外基礎與臨床雜志, 2003; 10(4)∶336.
26.	蔣智軍，鄭樹森，梁廷波，等. 再次肝移植治療移植肝失功的經驗分析 [J]. 中華外科雜志, 2006; 44(3)∶153.
27.	Oh CK, Pelletier SJ, Sawyer RG, et al. Uni- and multi-variate analysis of risk factors for early and late hepatic artery thrombosis after liver transplantation [J]. Transplantation， 2001; 71(6)∶767.
28.	Ueno T, Jones G, Martin A, et al. Clinical outcomes from hepatic artery stenting in liver transplantation [J]. Liver Transpl， 2006; 12(3)∶422.
29.	Saad WE, Davies MG, Sahler L, et al. Hepatic artery stenosis in liver transplant recipients: primary treatment with percutaneous transluminal angioplasty [J]. J Vasc Interv Radiol， 2005; 16(6)∶795.
30.	Garcia-Gallont R, Bar-Nathan N, Shaharabani E, et al. Hepatic artery thrombosis in pediatric liver transplantation: graft salvage after thrombectomy [J]. Pediatr Transplant， 1999; 3(1)∶74.

1. 　Washington K. Update on post-liver transplantation infections, malignancies, and surgical complications [J]. Adv Anat Pathol， 2005; 12(4)∶221.
2. 　陳煥偉, 甄作均, 蘇樹英, 等. 原位肝移植術后并發癥的診治體會(附16例報告) [J]. 中國普外基礎與臨床雜志, 2004; 11(5)∶163.
3. 　Boyvat F, Aytekin C, Firat A, et al. Diagnostic and therapeutic management of hepatic artery thrombosis and stenosis after orthotopic and heterotopic liver transplantation [J]. Transplant Proc， 2003; 35(7)∶2791.
4. 　李汛, 李玉民, 石斌, 等. 肝移植術后肝動脈血栓的防治(附2例報告) [J]. 中國普外基礎與臨床雜志, 2005; 12(5)∶511.
5. 　Stange BJ, Glanemann M, Nuessler NC, et al. Hepatic artery thrombosis after adult liver transplantation [J]. Liver Transpl， 2003; 9(6)∶612.
6. 　Dunn TB, Linden MA, Vercellotti GM, et al. Factor Ⅴ Leiden and hepatic artery thrombosis after liver transplantation [J]. Clin Transplant， 2006; 20(1)∶132.
7. 　Jain A, Costa G, Marsh W, et al. Thrombotic and nonthrombotic hepatic artery complications in adults and children following primary liver transplantation with long-term follow-up in 1 000 consecutive patients [J]. Transpl Int， 2006; 19(1)∶27.
8. 　Hirshfield G, Collier JD, Brown K, et al. Donor factor Ⅴ Leiden mutation and vascular thrombosis following liver transplantation [J]. Liver Transpl Surg， 1998; 4(1)∶58.
9. 　Ikegami T, Hashikura Y, Nakazawa Y, et al. Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation [J]. J Hepatobiliary Pancreat Surg， 2006; 13(2)∶105.
10. 　Silva MA, Jambulingam PS, Gunson BK, et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom [J]. Liver Transpl， 2006; 12(1)∶146.
11. 　Ishigami K, Zhang Y, Rayhill S, et al. Does variant hepatic artery anatomy in a liver transplant recipient increase the risk of hepatic artery complications after transplantation? [J]. AJR Am J Roentgenol， 2004; 183(6)∶1577.
12. 　Drazan K, Shaked A, Olthoff KM, et al. Etiology and management of symptomatic adult hepatic artery thrombosis after orthotopic liver transplantation (OLT) [J]. Am Surg， 1996; 62(3)∶237.
13. 　Proposito D, Loinaz Segurola C, Garcia Garcia I, et al. Assessment of risk factors in the incidence of hepatic artery thrombosis in a consecutive series of 687 liver transplantations [J]. Ann Ital Chir， 2001; 72(2)∶187.
14. 　Zhou J, Fan J, Wang JH, et al. Continuous transcatheter arterial thrombolysis for early hepatic artery thrombosis after liver transplantation [J]. Transplant Proc， 2005; 37(10)∶4426.
15. 　Uzochukwu LN, Bluth EI, Smetherman DH, et al. Early postoperative hepatic sonography as a predictor of vascular and biliary complications in adult orthotopic liver transplant patients [J]. AJR Am J Roentgenol， 2005; 185(6)∶1558.
16. 　Kaneko J, Sugawara Y, Akamatsu N, et al. Prediction of hepatic artery thrombosis by protocol Doppler ultrasonography in pediatric living donor liver transplantation [J]. Abdom Imaging， 2004; 29(5)∶603.
17. 　Lin M, Crawford M, Fisher J, et al. Hepatic artery thrombosis and intraoperative hepatic artery flow rates in adult orthotopic liver transplantation [J]. ANZ J Surg， 2002; 72(11)∶798.
18. 　Kubota K, Kita J, Shimoda M, et al. Intraoperative assessment of reconstructed vessels in living-donor liver transplantation, using a novel fluorescence imaging technique [J]. J Hepatobiliary Pancreat Surg， 2006; 13(2)∶100.
19. 　吳剛，劉永鋒，梁鍵，等. 原位肝移植肝動脈血栓形成的預防與治療 [J]. 中華普通外科雜志, 2005; 14(7)∶483.
20. 　Matsuda H, Yagi T, Sadamori H, et al. Complications of arterial reconstruction in living donor liver transplantation: a single-center experience [J]. Surg Today， 2006; 36(3)∶245.
21. 　Mazariegos GV, O’Toole K, Mieles LA, et al. Hyperbaric oxygen therapy for hepatic artery thrombosis after liver transplantation in children [J]. Liver Transpl Surg， 1999; 5(5)∶429.
22. 　Dubost T, Goubaux B, Duhalde M, et al. Use of hyperbaric oxygen for hepatic artery thrombosis following adult orthotopic liver transplantation [J]. Eur J Anaesthesiol， 2002; 19(3)∶223.
23. 　Grover I, Conley L, Alzate G, et al. Hyperbaric oxygen therapy for hepatic artery thrombosis following liver transplantation: current concepts [J]. Pediatr Transplant， 2006; 10(2)∶234.
24. 　陳規劃, 陸敏強, 蔡常潔, 等. 肝移植手術相關并發癥的防治 [J]. 中華外科雜志, 2006; 44(5)∶295.
25. 　李國強, 王學浩, 李相成, 等. 活體肝移植圍手術期處理 [J]. 中國普外基礎與臨床雜志, 2003; 10(4)∶336.
26. 　蔣智軍，鄭樹森，梁廷波，等. 再次肝移植治療移植肝失功的經驗分析 [J]. 中華外科雜志, 2006; 44(3)∶153.
27. 　Oh CK, Pelletier SJ, Sawyer RG, et al. Uni- and multi-variate analysis of risk factors for early and late hepatic artery thrombosis after liver transplantation [J]. Transplantation， 2001; 71(6)∶767.
28. 　Ueno T, Jones G, Martin A, et al. Clinical outcomes from hepatic artery stenting in liver transplantation [J]. Liver Transpl， 2006; 12(3)∶422.
29. 　Saad WE, Davies MG, Sahler L, et al. Hepatic artery stenosis in liver transplant recipients: primary treatment with percutaneous transluminal angioplasty [J]. J Vasc Interv Radiol， 2005; 16(6)∶795.
30. 　Garcia-Gallont R, Bar-Nathan N, Shaharabani E, et al. Hepatic artery thrombosis in pediatric liver transplantation: graft salvage after thrombectomy [J]. Pediatr Transplant， 1999; 3(1)∶74.

《中國普外基礎與臨床雜志》

肝移植后肝動脈血栓形成的危險因素及防治措施

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

肝移植后肝動脈血栓形成的危險因素及防治措施

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料