促血管生成素與胃癌血管生成的關系_《中國普外基礎與臨床雜志》

作者：

楊華 , 陳志新

四川大學華西醫院普外科（成都610041）;

關鍵詞：

胃癌促血管生成素血管生成

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　探討促血管生成素與胃癌微血管生成的關系，以及與胃癌微循環中存在的各種血管生長因子間的相互調控作用。
方法　采用文獻回顧的方法，對有關促血管生成素和胃癌血管生成的關系進行綜述。
結果　促血管生成素在胃癌微循環中的表達與胃癌的血管生成有關系，但與各種血管生成因子之間的相互調控作用仍存在爭議。
結論　促血管生成素在胃癌微小血管的萌芽、發展、凋亡等一系列過程中扮演著重要的角色。

引用本文： 楊華,陳志新. 促血管生成素與胃癌血管生成的關系. 中國普外基礎與臨床雜志, 2007, 14(3): 368-370. doi: 復制

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14.	DeBusk LM, Hallahan DE, Lin PC. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway [J].Exp Cell Res， 2004; 298(1)∶167.
15.	Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2 [J]. Proc Natl Acad Sci USA， 1998; 95(15)∶8829.
16.	Siemeister G, Schirner M, Weindel K, et al. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway [J]. Cancer Res， 1999; 59(13)∶3185.
17.	羅彥，文艷君，田聆，等. 雞tie-2受體胞外片段重組蛋白的制備及其抗血管生成作用的研究 [J]. 中華醫學遺傳學雜志， 2004； 21（2）∶101.
18.	羅彥，田聆，吳揚，等. 雞Tie-2受體胞外片段的原核表達及目的蛋白免疫原性的研究 [J]. 四川大學學報（醫學版）， 2004； 35（2）∶154.
19.	王天寶，李兆亭. 血管內皮生長因子及微血管密度與胃癌進展的關系 [J]. 中國普外基礎與臨床雜志， 2002； 9（3）∶159.

1. Folkman J. Tumor angiogenesis: therapeutic implications [J]. N Engl J Med, 1971; 285(21)∶1182.
2. Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [J]. Cell， 1996; 87(7)∶1171.
3. Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [J]. Science， 1997; 277(5322)∶55.
4. Sato TN, Qin Y, Kozak CA, et al. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system [J]. Proc Natl Acad Sci USA， 1993; 90(20)∶9355.
5. Fiedler U, Krissl T, Koidl S, et al. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats [J]. J Biol Chem， 2003; 278(3)∶1721.
6. Sato TN, Tozawa Y, Deutsch U, et al.Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation [J]. Nature， 1995; 376(6535)∶70.
7. 孫秀菊, 付浩, 鄭志紅，等. Ang2基因表達與胃癌發生發展的關系 [J]. 中國腫瘤臨床， 2003； 30（8）∶536.
8. Etoh T, Inoue H, Tanaka S, et al. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases [J]. Cancer Res， 2001; 61(5)∶2145.
9. 張寧，陶凱雄，王國斌，等. 環氧合酶-2及血管生成素-2在大腸癌中的表達及臨床意義 [J]. 中國普外基礎與臨床雜志， 2006； 13（5）∶564.
10. Du JR, Jiang Y, Zhang YM, et al. Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas [J]. World J Gastroenterol， 2003; 9(7)∶1604.
11. Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’Kinase/Akt signal transduction pathway [J].Circ Res， 2000; 86(1)∶24.
12. Fujikawa K, de Aos Scherpenseel I, Jain SK, et al. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells [J]. Exp Cell Res， 1999; 253(2)∶663.
13. Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem， 2000; 275(13)∶9102.
14. DeBusk LM, Hallahan DE, Lin PC. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway [J].Exp Cell Res， 2004; 298(1)∶167.
15. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2 [J]. Proc Natl Acad Sci USA， 1998; 95(15)∶8829.
16. Siemeister G, Schirner M, Weindel K, et al. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway [J]. Cancer Res， 1999; 59(13)∶3185.
17. 羅彥，文艷君，田聆，等. 雞tie-2受體胞外片段重組蛋白的制備及其抗血管生成作用的研究 [J]. 中華醫學遺傳學雜志， 2004； 21（2）∶101.
18. 羅彥，田聆，吳揚，等. 雞Tie-2受體胞外片段的原核表達及目的蛋白免疫原性的研究 [J]. 四川大學學報（醫學版）， 2004； 35（2）∶154.
19. 王天寶，李兆亭. 血管內皮生長因子及微血管密度與胃癌進展的關系 [J]. 中國普外基礎與臨床雜志， 2002； 9（3）∶159.

《中國普外基礎與臨床雜志》

促血管生成素與胃癌血管生成的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

《中國普外基礎與臨床雜志》

促血管生成素與胃癌血管生成的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料