造血干細胞微環境中的相互調節_《中國普外基礎與臨床雜志》

作者：

梁越洋 , 吳誠義

重慶醫科大學附屬第一醫院內分泌外科（重慶 400016 ）;

關鍵詞：

造血干細胞 , 微環境 , 成骨細胞

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】目的對造血干細胞（hematopoietic stem cell）微環境的研究現狀作一綜述。方法閱讀近年國內、外相關文獻,對造血干細胞微環境的組成,以及參與調控造血干細胞的相關細胞因子及相關細胞信號通路的研究進展進行總結。結果造血干細胞的活動通過與周圍細胞構成的微環境（即干細胞微環境）來控制的，其調控不可能通過一種信號通路來完成，當然也不可能僅僅通過成骨細胞來單獨完成對造血干細胞自我更新和分化調節。結論微環境對造血干細胞的調節通過多環節起作用,隨著對其研究的深入可以使我們對干細胞的性質有更全面的了解，并且對以干細胞為基礎的治療提供更廣闊的空間。

引用本文： 梁越洋,吳誠義. 造血干細胞微環境中的相互調節. 中國普外基礎與臨床雜志, 2008, 15(3): 171-173. doi: 復制

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16.	Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J]. Cell, 2004; 118(2)∶149.
17.	Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J]. Cell, 1996; 87(7)∶1161.
18.	Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1 [J]. Science, 2000; 287(5459)∶1804.
19.	Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’-Kinase/Akt signal transduction pathway [J]. Circ Res, 2000; 86(1)∶24.
20.	Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis [J]. Circ Res, 2002; 90(12)∶1243.
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22.	Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells [J]. Cancer Res, 2003; 63(1)∶196.
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25.	Reya T. Regulation of hematopoietic stem cell self-renewal [J]. Recent Prog Horm Res, 2003; 58∶283.
26.	Rattis FM, Voermans C, Reya T. Wnt signaling in the stem cell niche [J]. Curr Opin Hematol, 2004; 11(2)∶88.
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28.	Jamora C, DasGupta R, Kocieniewski P, et al. Links between signal transduction, transcription and adhesion in epithelial bud development [J]. Nature, 2003; 422(6929)∶317.
29.	Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance [J]. Nat Immunol, 2005; 6(3)∶314.
30.	Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J]. Nat Immunol, 2001; 2(2)∶172.
31.	Katayama Y, Battista M, Kao WM, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow [J]. Cell, 2006; 124(2)∶407.

1. 31 Semerad CL, Christopher MJ, Liu F, et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow [ J ] . Blood, 2005; 106(9) ∶ 3020.
2. Gordon A Ed. Regulation of hematopoietic stem cells [M]. New York: Appleton Century Crofts， 1970∶161-185.
3. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell [J]. Blood Cells, 1978; 4(1-2)∶7.
4. Moore KA. Recent advances in defining the hematopoietic stem cell niche [J]. Curr Opin Hematol, 2004; 11(2)∶107.
5. Perkins S, Fleischman RA. Hematopoietic microenvironment. Origin, lineage, and transplantability of the stromal cells in long-term bone marrow cultures from chimeric mice [J]. J Clin Invest, 1988; 81(4)∶1072.
6. 付相建, 陳幸華. 造血微環境對急性白血病細胞的作用研究進展 [J]. 西南軍醫, 2006; 8(1)∶66.
7. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999; 284(5411)∶143.
8. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche [J]. Nature, 2001; 414(6859)∶98.
9. 馮振月, 潘敏慧, 魯成. 果蠅生殖腺干細胞和它們的微環境 [J]. 細胞生物學雜志, 2006; 28(1)∶169.
10. Suda T, Arai F, Shimmura S. Regulation of stem cells in the niche [J]. Cornea, 2005; 24(8 Suppl)∶S12.
11. Cosimo DB, Pringle S, Pitzalis C, et al. The stem cell niche: a new target in medicine [J]. Curr Opin Orthop, 2006; 17(5)∶398.
12. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size [J]. Nature, 2003; 425(6960)∶836.
13. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche [J]. Nature, 2003; 425(6960)∶841.
14. Visnjic D, Kalajzic Z, Rowe DW, et al. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency [J]. Blood, 2004; 103(9)∶3258.
15. Cheshier SH, Morrison SJ, Liao X, et al. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells [J]. Proc Natl Acad Sci USA, 1999; 96(6)∶3120.
16. Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J]. Cell, 2004; 118(2)∶149.
17. Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J]. Cell, 1996; 87(7)∶1161.
18. Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1 [J]. Science, 2000; 287(5459)∶1804.
19. Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’-Kinase/Akt signal transduction pathway [J]. Circ Res, 2000; 86(1)∶24.
20. Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis [J]. Circ Res, 2002; 90(12)∶1243.
21. Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival [J]. J Biol Chem, 2002; 277(13)∶11352.
22. Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells [J]. Cancer Res, 2003; 63(1)∶196.
23. Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective [J]. Biotechniques, 2003; 35(6)∶1240.
24. van de Wetering M, de Lau W, Clevers H. WNT signaling and lymphocyte development [J]. Cell, 2002; 109(Suppl)∶S13.
25. Reya T. Regulation of hematopoietic stem cell self-renewal [J]. Recent Prog Horm Res, 2003; 58∶283.
26. Rattis FM, Voermans C, Reya T. Wnt signaling in the stem cell niche [J]. Curr Opin Hematol, 2004; 11(2)∶88.
27. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells [J]. Nature, 2003; 423(6938)∶409.
28. Jamora C, DasGupta R, Kocieniewski P, et al. Links between signal transduction, transcription and adhesion in epithelial bud development [J]. Nature, 2003; 422(6929)∶317.
29. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance [J]. Nat Immunol, 2005; 6(3)∶314.
30. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J]. Nat Immunol, 2001; 2(2)∶172.
31. Katayama Y, Battista M, Kao WM, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow [J]. Cell, 2006; 124(2)∶407.

《中國普外基礎與臨床雜志》

造血干細胞微環境中的相互調節

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

造血干細胞微環境中的相互調節

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料