基質金屬蛋白酶對胃癌微環境調控作用的研究進展_《中國普外基礎與臨床雜志》

作者：

江州華 , 俞繼衛 , 姜波健

上海交通大學醫學院附屬第三人民醫院普外科(上海201900);

關鍵詞：

基質金屬蛋白酶胃癌增殖侵襲轉移血管形成凋亡

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　介紹基質金屬蛋白酶(MMPs)在胃癌發生、發展中的作用。
方法　收集近年來國內、外有關MMPs與胃癌關系的文獻并作綜述。
結果　胃癌的發生、發展是多步驟、多因素的復雜過程，其病因和發病機理仍未完全闡明。MMPs是一類蛋白水解酶，它們通過對腫瘤生長的微環境進行調控,進而在胃癌演進中的增殖、轉移、新生血管形成和調控腫瘤細胞及其周圍正常細胞凋亡的過程中均起著重要的作用。
結論　MMPs從不同的方面促進胃癌的演進，了解這些方面的機理可以為未來胃癌的治療提供理論依據。

引用本文： 江州華,俞繼衛,姜波健. 基質金屬蛋白酶對胃癌微環境調控作用的研究進展. 中國普外基礎與臨床雜志, 2009, 16(9): 768-772. doi: 復制

1.	張鵬, 俞繼衛, 姜波健. 腫瘤干細胞與胃腸道癌發生和轉移 [Ｊ]. 中國普外基礎與臨床雜志, 2009; 16(1): 81-84.
2.	Woessner JF Jr. MMPs and TIMPs－an historical perspective [Ｊ]. Mol Biotechnol, 2002; 22(1): 33-49.
3.	McCawley LJ, Matrisian LM. Matrix metalloproteinases: th-ey’re not just for matrix anymore! [Ｊ]. Curr Opin Cell Biol, 2001; 13(5): 534-540.
4.	Yu WH, Woessner JF Jr, McNeish JD, et al. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling [Ｊ]. Genes Dev, 2002; 16(3): 307-323.
5.	Suzuki M, Raab G, Moses MA, et al. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site [Ｊ]. J Biol Chem, 1997; 272(50): 31730-31737.
6.	Rauvala M, Aglund K, Puistola U, et al. Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression [Ｊ]. Int J Gynecol Cancer, 2006; 16(3): 1297-1302.
7.	Tatti O, Vehvilinen P, Lehti K, et al. MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1 [Ｊ]. Exp Cell Res, 2008； 314(13): 2501-2514.
8.	Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin αvβ6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis [Ｊ]. Am J Respir Crit Care Med, 2008; 177(1): 82-90.
9.	Miyamoto S, Nakamura M, Yano K, et al. Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-Ⅱ via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix [Ｊ]. Cancer Sci, 2007; 98(5): 685-691.
10.	Mysliwy J, Dingley AJ, Sedlacek R, et al. Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19 [Ｊ]. Protein Expr Purif, 2006; 46(2): 406-413.
11.	Gennigens C, Menetrier-Caux C, Droz JP. Insulin-like gro-wth factor (IGF) family and prostate cancer [Ｊ]. Crit Rev Oncol Hematol, 2006; 58(2): 124-145.
12.	Uttamsingh S, Bao X, Nguyen KT, et al. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells [Ｊ]. Oncogene, 2008; 27(18): 2626-2634.
13.	Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer [Ｊ]. Endocr Relat Cancer, 2004; 11(4): 709-724.
14.	Zheng H, Takahashi H, Murai Y, et al. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Anticancer Res, 2006; 26(5A): 3579-3583.
15.	Zheng HC, Sun JM, Li XH, et al. Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Pathol Int, 2003; 53(10): 659-666.
16.	Yasui W, Oue N, Aung PP, et al. Molecular-pathological prognostic factors of gastric cancer: a review [Ｊ]. Gastric Cancer, 2005; 8(2): 86-94.
17.	Elnemr A, Yonemura Y, Bandou E, et al. Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer [Ｊ]. Gastric Cancer, 2003; 6(1): 30-38.
18.	嚴冬, 沈琳, 呂尤勇. MMP-11在胃癌患者血清中的表達及臨床意義 [Ｊ]. 中國癌癥雜志, 2007; 17(12): 968-972.
19.	Friedl P, Brcker EB. The biology of cell locomotion within three-dimensional extracellular matrix [Ｊ]. Cell Mol Life Sci, 2000; 57(1): 41-64.
20.	Dittmar T, Heyder C, Gloria-Maercker E, et al. Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner [Ｊ]. Clin Exp Metastasis, 2008; 25(1): 11-32.
21.	Hornebeck W, Emonard H, Maquart FX, et al. Proteolysis directed by the extracellular matrix [Ｊ]. J Soc Biol, 2003; 197(1): 25-30.
22.	Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail’s pace [Ｊ]. Int J Biochem Cell Biol, 2007; 39(6): 1082-1088.
23.	徐勝軍, 胡炳奎, 凌志強, 等. CD44v6在胃癌中的表達及其臨床意義 [Ｊ]. 中國普外基礎與臨床雜志, 2006; 13(1): 42-44.
24.	Giannelli G, Falk-Marzillier J, Schiraldi O, et al. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5 [Ｊ]. Science, 1997; 277(5323): 225-228.
25.	Nisato RE, Hosseini G, Sirrenberg C, et al. Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical [Ｊ]. Cancer Res, 2005; 65(20): 9377-9387.
26.	Deryugina EI, Soroceanu L, Strongin AY. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis [Ｊ]. Cancer Res, 2002; 62(2): 580-588.
27.	Dean RA, Butler GS, Hamma-Kourbali Y, et al. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis [Ｊ]. Mol Cell Biol, 2007; 27(24): 8454-8465.
28.	Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 [Ｊ]. J Biol Chem, 2002; 277(39): 36288-36295.
29.	Ito TK, Ishii G, Chiba H, et al. The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells [Ｊ]. Oncogene, 2007; 26(51): 7194-7203.
30.	Soff GA. Angiostatin and angiostatin-related proteins [Ｊ]. Cancer Metastasis Rev, 2000; 19(1-2): 97-107.
31.	Pozzi A, LeVine WF, Gardner HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis [Ｊ]. Oncogene, 2002; 21(2): 272-281.
32.	Jodele S, Blavier L, Yoon JM, et al. Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression [Ｊ]. Cancer Metastasis Rev, 2006; 25(1): 35-43.
33.	俞繼衛, 姜波健. 胃癌浸潤和轉移中基質金屬蛋白酶及其抑制劑的分子基礎和臨床價值 [Ｊ]. 腹部外科, 2007; 20(4): 245-247.

1. 張鵬, 俞繼衛, 姜波健. 腫瘤干細胞與胃腸道癌發生和轉移 [Ｊ]. 中國普外基礎與臨床雜志, 2009; 16(1): 81-84.
2. Woessner JF Jr. MMPs and TIMPs－an historical perspective [Ｊ]. Mol Biotechnol, 2002; 22(1): 33-49.
3. McCawley LJ, Matrisian LM. Matrix metalloproteinases: th-ey’re not just for matrix anymore! [Ｊ]. Curr Opin Cell Biol, 2001; 13(5): 534-540.
4. Yu WH, Woessner JF Jr, McNeish JD, et al. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling [Ｊ]. Genes Dev, 2002; 16(3): 307-323.
5. Suzuki M, Raab G, Moses MA, et al. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site [Ｊ]. J Biol Chem, 1997; 272(50): 31730-31737.
6. Rauvala M, Aglund K, Puistola U, et al. Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression [Ｊ]. Int J Gynecol Cancer, 2006; 16(3): 1297-1302.
7. Tatti O, Vehvilinen P, Lehti K, et al. MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1 [Ｊ]. Exp Cell Res, 2008； 314(13): 2501-2514.
8. Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin αvβ6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis [Ｊ]. Am J Respir Crit Care Med, 2008; 177(1): 82-90.
9. Miyamoto S, Nakamura M, Yano K, et al. Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-Ⅱ via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix [Ｊ]. Cancer Sci, 2007; 98(5): 685-691.
10. Mysliwy J, Dingley AJ, Sedlacek R, et al. Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19 [Ｊ]. Protein Expr Purif, 2006; 46(2): 406-413.
11. Gennigens C, Menetrier-Caux C, Droz JP. Insulin-like gro-wth factor (IGF) family and prostate cancer [Ｊ]. Crit Rev Oncol Hematol, 2006; 58(2): 124-145.
12. Uttamsingh S, Bao X, Nguyen KT, et al. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells [Ｊ]. Oncogene, 2008; 27(18): 2626-2634.
13. Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer [Ｊ]. Endocr Relat Cancer, 2004; 11(4): 709-724.
14. Zheng H, Takahashi H, Murai Y, et al. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Anticancer Res, 2006; 26(5A): 3579-3583.
15. Zheng HC, Sun JM, Li XH, et al. Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Pathol Int, 2003; 53(10): 659-666.
16. Yasui W, Oue N, Aung PP, et al. Molecular-pathological prognostic factors of gastric cancer: a review [Ｊ]. Gastric Cancer, 2005; 8(2): 86-94.
17. Elnemr A, Yonemura Y, Bandou E, et al. Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer [Ｊ]. Gastric Cancer, 2003; 6(1): 30-38.
18. 嚴冬, 沈琳, 呂尤勇. MMP-11在胃癌患者血清中的表達及臨床意義 [Ｊ]. 中國癌癥雜志, 2007; 17(12): 968-972.
19. Friedl P, Brcker EB. The biology of cell locomotion within three-dimensional extracellular matrix [Ｊ]. Cell Mol Life Sci, 2000; 57(1): 41-64.
20. Dittmar T, Heyder C, Gloria-Maercker E, et al. Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner [Ｊ]. Clin Exp Metastasis, 2008; 25(1): 11-32.
21. Hornebeck W, Emonard H, Maquart FX, et al. Proteolysis directed by the extracellular matrix [Ｊ]. J Soc Biol, 2003; 197(1): 25-30.
22. Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail’s pace [Ｊ]. Int J Biochem Cell Biol, 2007; 39(6): 1082-1088.
23. 徐勝軍, 胡炳奎, 凌志強, 等. CD44v6在胃癌中的表達及其臨床意義 [Ｊ]. 中國普外基礎與臨床雜志, 2006; 13(1): 42-44.
24. Giannelli G, Falk-Marzillier J, Schiraldi O, et al. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5 [Ｊ]. Science, 1997; 277(5323): 225-228.
25. Nisato RE, Hosseini G, Sirrenberg C, et al. Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical [Ｊ]. Cancer Res, 2005; 65(20): 9377-9387.
26. Deryugina EI, Soroceanu L, Strongin AY. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis [Ｊ]. Cancer Res, 2002; 62(2): 580-588.
27. Dean RA, Butler GS, Hamma-Kourbali Y, et al. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis [Ｊ]. Mol Cell Biol, 2007; 27(24): 8454-8465.
28. Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 [Ｊ]. J Biol Chem, 2002; 277(39): 36288-36295.
29. Ito TK, Ishii G, Chiba H, et al. The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells [Ｊ]. Oncogene, 2007; 26(51): 7194-7203.
30. Soff GA. Angiostatin and angiostatin-related proteins [Ｊ]. Cancer Metastasis Rev, 2000; 19(1-2): 97-107.
31. Pozzi A, LeVine WF, Gardner HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis [Ｊ]. Oncogene, 2002; 21(2): 272-281.
32. Jodele S, Blavier L, Yoon JM, et al. Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression [Ｊ]. Cancer Metastasis Rev, 2006; 25(1): 35-43.
33. 俞繼衛, 姜波健. 胃癌浸潤和轉移中基質金屬蛋白酶及其抑制劑的分子基礎和臨床價值 [Ｊ]. 腹部外科, 2007; 20(4): 245-247.

《中國普外基礎與臨床雜志》

基質金屬蛋白酶對胃癌微環境調控作用的研究進展

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《中國普外基礎與臨床雜志》

基質金屬蛋白酶對胃癌微環境調控作用的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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