乳腺內乳淋巴結在乳腺癌診治中的臨床意義_《中國普外基礎與臨床雜志》

作者：

易江 , 呂青 , 朱精強

四川大學華西醫院甲狀腺乳腺外科（成都 610041）;

關鍵詞：

內乳淋巴結乳腺癌活檢放射治療預后

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的探討乳腺內乳淋巴結在乳腺癌診治中的臨床意義。
方法通過分析國內、外關于內乳淋巴結的相關研究，總結乳腺癌中乳腺內乳淋巴結的分布、轉移、檢測及臨床治療的效果。
結果乳腺內乳淋巴結主要分布在胸骨附近，沿胸內乳動、靜脈走行，在乳腺癌中能夠發生早期轉移且轉移率隨腋淋巴結轉移數目的增多而增加，對內乳淋巴結的活檢和治療能影響乳腺癌患者的預后。
結論內乳淋巴結的活檢和治療有助于乳腺癌的精確分期、治療和預后判斷, 同時也是防止乳腺癌復發的有效手段。

引用本文： 易江,呂青,朱精強. 乳腺內乳淋巴結在乳腺癌診治中的臨床意義. 中國普外基礎與臨床雜志, 2009, 16(7): 531-533. doi: 復制

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2.	Handley R. Natural history of breast cancer [Ａ]. In: Harris J, Li ppman ME, Morrow M, et al (eds). Diseases of the Breast [Ｍ]. Philadelphia: WB Saunders, 1996: 384385.
3.	Haagensen CD, Bhonslay SB, Guttmann RJ, et al. Metastasis of carcinoma of the breast to the periphery of regional node filter[J]. Ann Surg, 1969; 169(2): 174190.
4.	Scatarige JC, Fishman EK, Zinreich ES, et al. Internal mammary lymphadenopathy in breast carcinoma: CT appraisal of anatomic distribution [J]. Radiology, 1988; 167(1): 8991.
5.	Veronesi U, Marubini E, Mariani L, et al. The dissection of internal mammary nodes does not improve the survival of breast cancer patients: 30 year results of a randomized trial [J]. Eur J Cancer, 1999; 35 (9): 13201325.
6.	Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer [J]. J Clin Oncol, 2002; 20 (17): 36283636.
7.	Ferlicot S, VincentSalomon A, Médioni J, et al. Wide metastatic spreading in infiltrating lobular carcinoma of the breast [J]. Eur J Cancer, 2004; 40(3): 336341.
8.	American Society of Clinical Oncology. Guide to breast cancer. 2007 revision. Available from: http: // www.plwc.org.
9.	NCCN Clinical Practice Guidelines in Oncology. Breast cancer. V. 2 .2008. Available from: http: //www. nccn.org.
10.	Madsen E, Gobardhan P, Bongers V, et al. The impact on post surgical treatment of sentinel lymph node biopsy of internal mammary lymph nodes in patients with breast cancer [J]. Ann Surg Oncol, 2007; 14(4): 14861492.
11.	Veronesi U, Cascinelli N, Greco M, et al. Prognosis of breast cancer patients after mastectomy and dissection of internal mammary nodes [J]. Ann Surg, 1985; 202 (6): 702707.
12.	Gaffney DK, Tsodikov A, Wiggins CL. Diminished survival in patients with inner versus outer quadrant breast cancers [J]. J Clin Oncol, 2003; 21(3): 467472.
13.	黃歐，凌泓，沈坤煒，等. 1679例乳腺癌內乳淋巴結轉移的高危因素分析 [J]. 中國實用外科雜志, 2006; 26(4): 270274.
14.	Wu CT, Morita ET, Treseler PA, et al. Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patients[J]. Breast J, 2003; 9(2):8690.
15.	賀青卿, 楊新華, 郭美琴, 等. 胸腔鏡內乳淋巴鏈清掃的臨床研究 [J]. 第三軍醫大學學報, 2005; 27(22): 22902292.
16.	陳捷鑫，林鵬, 樊衛, 等. 乳腺癌內乳淋巴結活檢的臨床研究 [J]. 癌癥, 2007; 26(2): 172177.
17.	Cranenbroek S, van der Sangen MJ, Kuijt GP, et al. Diagnosis, treatment and prognosis of internal mammary lymph node recurronce in breast cancer patients [J]. Breast Cancer Res Treat, 2005; 89(3): 271275.
18.	vander Sangen MJ, Coebergh JW, Roumen RM, et al. Detection, treatment and outcome of isolated supraclavicular recurrence in 42 patients with invasive breast carcinoma[J]. Cancer, 2003; 98(1): 1117.
19.	Cancer Research Campaign Working Party. Cancer research campaign (King’s/Cambridge) trial for early breast cancer. A detailed update at the tenth year [J]. Lancet, 1980; 2(8185): 5560.
20.	Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in highrisk postmenopauzal breast cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial[J]. Lancet, 1999; 353(9165): 16411648.
21.	Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in nodepositive premenopausal women with breast cancer [J]. N Engl J Med, 1997; 337(14): 956962.
22.	Cuzick J, Stewart H, Peto R, et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer[J]. Cancer Treat Rep, 1987; 71(1):1529.
23.	Cuzick J, Stewart H, Rutqvist L, et al. Causespecific mortality in longterm survivors of breast cancer who participated in trials of radiotherapy[J]. J Clin Oncol 1994; 12(3): 447453.
24.	仇愛峰，徐青，王慶慶. 新輔助化療對乳腺癌患者腋窩前哨淋巴結活檢的影響 [J]. 山東醫藥, 2005; 45(36): 3435.
25.	Ogawa Y, Ishikawa T, Sawada T, et al. Thoracoscopic internal mammary sentinel node biopsy for breast cancer [J]. Surg Endosc, 2003; 17(2): 315319.
26.	賀青卿, 姜軍, 楊新華, 等. 乳腺癌淋巴引流途徑的臨床研究 [J/CD]. 中華乳腺病雜志(電子版), 2008; 2(2): 140148.
27.	沈鎮宙, 韓企夏, 李月云. 乳腺癌擴大根治術1 091例分析 [J]. 上海醫學, 1982; 5(9): 499503.
28.	Veronesi U, Marubini E, Mariani L, et al. The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30year results of a randomised trial [J]. Eur J Cancer, 1999; 35(9): 13201325.

1. Tanis PJ, Nieweg OE, Valdés Olmos RA, et al. Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy [J]. J Am Coll Surg, 2001; 192(3): 399409.
2. Handley R. Natural history of breast cancer [Ａ]. In: Harris J, Li ppman ME, Morrow M, et al (eds). Diseases of the Breast [Ｍ]. Philadelphia: WB Saunders, 1996: 384385.
3. Haagensen CD, Bhonslay SB, Guttmann RJ, et al. Metastasis of carcinoma of the breast to the periphery of regional node filter[J]. Ann Surg, 1969; 169(2): 174190.
4. Scatarige JC, Fishman EK, Zinreich ES, et al. Internal mammary lymphadenopathy in breast carcinoma: CT appraisal of anatomic distribution [J]. Radiology, 1988; 167(1): 8991.
5. Veronesi U, Marubini E, Mariani L, et al. The dissection of internal mammary nodes does not improve the survival of breast cancer patients: 30 year results of a randomized trial [J]. Eur J Cancer, 1999; 35 (9): 13201325.
6. Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer [J]. J Clin Oncol, 2002; 20 (17): 36283636.
7. Ferlicot S, VincentSalomon A, Médioni J, et al. Wide metastatic spreading in infiltrating lobular carcinoma of the breast [J]. Eur J Cancer, 2004; 40(3): 336341.
8. American Society of Clinical Oncology. Guide to breast cancer. 2007 revision. Available from: http: // www.plwc.org.
9. NCCN Clinical Practice Guidelines in Oncology. Breast cancer. V. 2 .2008. Available from: http: //www. nccn.org.
10. Madsen E, Gobardhan P, Bongers V, et al. The impact on post surgical treatment of sentinel lymph node biopsy of internal mammary lymph nodes in patients with breast cancer [J]. Ann Surg Oncol, 2007; 14(4): 14861492.
11. Veronesi U, Cascinelli N, Greco M, et al. Prognosis of breast cancer patients after mastectomy and dissection of internal mammary nodes [J]. Ann Surg, 1985; 202 (6): 702707.
12. Gaffney DK, Tsodikov A, Wiggins CL. Diminished survival in patients with inner versus outer quadrant breast cancers [J]. J Clin Oncol, 2003; 21(3): 467472.
13. 黃歐，凌泓，沈坤煒，等. 1679例乳腺癌內乳淋巴結轉移的高危因素分析 [J]. 中國實用外科雜志, 2006; 26(4): 270274.
14. Wu CT, Morita ET, Treseler PA, et al. Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patients[J]. Breast J, 2003; 9(2):8690.
15. 賀青卿, 楊新華, 郭美琴, 等. 胸腔鏡內乳淋巴鏈清掃的臨床研究 [J]. 第三軍醫大學學報, 2005; 27(22): 22902292.
16. 陳捷鑫，林鵬, 樊衛, 等. 乳腺癌內乳淋巴結活檢的臨床研究 [J]. 癌癥, 2007; 26(2): 172177.
17. Cranenbroek S, van der Sangen MJ, Kuijt GP, et al. Diagnosis, treatment and prognosis of internal mammary lymph node recurronce in breast cancer patients [J]. Breast Cancer Res Treat, 2005; 89(3): 271275.
18. vander Sangen MJ, Coebergh JW, Roumen RM, et al. Detection, treatment and outcome of isolated supraclavicular recurrence in 42 patients with invasive breast carcinoma[J]. Cancer, 2003; 98(1): 1117.
19. Cancer Research Campaign Working Party. Cancer research campaign (King’s/Cambridge) trial for early breast cancer. A detailed update at the tenth year [J]. Lancet, 1980; 2(8185): 5560.
20. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in highrisk postmenopauzal breast cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial[J]. Lancet, 1999; 353(9165): 16411648.
21. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in nodepositive premenopausal women with breast cancer [J]. N Engl J Med, 1997; 337(14): 956962.
22. Cuzick J, Stewart H, Peto R, et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer[J]. Cancer Treat Rep, 1987; 71(1):1529.
23. Cuzick J, Stewart H, Rutqvist L, et al. Causespecific mortality in longterm survivors of breast cancer who participated in trials of radiotherapy[J]. J Clin Oncol 1994; 12(3): 447453.
24. 仇愛峰，徐青，王慶慶. 新輔助化療對乳腺癌患者腋窩前哨淋巴結活檢的影響 [J]. 山東醫藥, 2005; 45(36): 3435.
25. Ogawa Y, Ishikawa T, Sawada T, et al. Thoracoscopic internal mammary sentinel node biopsy for breast cancer [J]. Surg Endosc, 2003; 17(2): 315319.
26. 賀青卿, 姜軍, 楊新華, 等. 乳腺癌淋巴引流途徑的臨床研究 [J/CD]. 中華乳腺病雜志(電子版), 2008; 2(2): 140148.
27. 沈鎮宙, 韓企夏, 李月云. 乳腺癌擴大根治術1 091例分析 [J]. 上海醫學, 1982; 5(9): 499503.
28. Veronesi U, Marubini E, Mariani L, et al. The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30year results of a randomised trial [J]. Eur J Cancer, 1999; 35(9): 13201325.

《中國普外基礎與臨床雜志》

乳腺內乳淋巴結在乳腺癌診治中的臨床意義

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《中國普外基礎與臨床雜志》

乳腺內乳淋巴結在乳腺癌診治中的臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料