應用肝移植治療神經內分泌腫瘤肝轉移的新進展_《中國普外基礎與臨床雜志》

作者：

靳曙光 , 嚴律南

四川大學華西醫院肝臟及血管外科（成都 610041）;

關鍵詞：

肝移植神經內分泌腫瘤腫瘤轉移類癌受體肝臟外科

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目的介紹肝移植治療神經內分泌腫瘤肝轉移的進展。方法收集國內、外近年來有關肝移植治療神經內分泌腫瘤肝轉移的文獻并進行分析和綜述。結果神經內分泌腫瘤進展緩慢，對于不能切除的肝臟神經內分泌轉移瘤，經過嚴格的臨床和病理組織學評估后實行肝移植，癥狀能夠有效地緩解甚至可能治愈。結論選擇合適的患者，肝移植治療神經內分泌腫瘤肝轉移效果良好。

引用本文： 靳曙光,嚴律南. 應用肝移植治療神經內分泌腫瘤肝轉移的新進展. 中國普外基礎與臨床雜志, 2009, 16(6): 449-451. doi: 復制

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2.	Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
3.	Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
4.	Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
5.	Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
6.	Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
7.	Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
8.	Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
9.	Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
10.	Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
11.	Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
12.	Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
13.	Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
14.	Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
15.	Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
16.	Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
17.	Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
18.	Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
19.	van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
20.	Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
21.	Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
22.	Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
23.	Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
24.	嚴律南, 王震俠. 肝癌肝移植的適應證及應用前景 [Ｊ]. 中國普外基礎與臨床雜志, 2006; 13(2): 132-134.
25.	陸敏強, 陳規劃, 楊揚, 等. pTNM分期預測肝癌肝移植療效的臨床研究 [Ｊ]. 中國普外基礎與臨床雜志, 2004; 11(5): 393-395.
26.	嚴律南, 金立人, 李波, 等. 同種異體原位肝移植10例報告 [Ｊ]. 中國普外基礎與臨床雜志, 2000; 7(4): 231-234.
27.	徐明清, 嚴律南, 李波, 等. 肝移植治療胰腺惡性β-細胞瘤肝轉移一例 [Ｊ]. 中華外科雜志, 2008; 46(4): 319.

1. Newton JN, Swerdlow AJ, dos Santos Silva IM, et al. The epidemiology of carcinoid tumours in England and Scotland [Ｊ]. Br J Cancer, 1994; 70(5): 939-942.
2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
3. Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
4. Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
5. Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
6. Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
7. Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
8. Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
9. Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
10. Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
11. Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
12. Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
13. Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
14. Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
15. Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
16. Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
17. Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
18. Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
19. van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
20. Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
21. Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
22. Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
23. Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
24. 嚴律南, 王震俠. 肝癌肝移植的適應證及應用前景 [Ｊ]. 中國普外基礎與臨床雜志, 2006; 13(2): 132-134.
25. 陸敏強, 陳規劃, 楊揚, 等. pTNM分期預測肝癌肝移植療效的臨床研究 [Ｊ]. 中國普外基礎與臨床雜志, 2004; 11(5): 393-395.
26. 嚴律南, 金立人, 李波, 等. 同種異體原位肝移植10例報告 [Ｊ]. 中國普外基礎與臨床雜志, 2000; 7(4): 231-234.
27. 徐明清, 嚴律南, 李波, 等. 肝移植治療胰腺惡性β-細胞瘤肝轉移一例 [Ｊ]. 中華外科雜志, 2008; 46(4): 319.

《中國普外基礎與臨床雜志》

應用肝移植治療神經內分泌腫瘤肝轉移的新進展

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《中國普外基礎與臨床雜志》

應用肝移植治療神經內分泌腫瘤肝轉移的新進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料