胰腺星狀細胞在胰腺纖維化中的作用_《中國普外基礎與臨床雜志》

作者：

鄭振江 , 向光明 , 劉續寶

四川大學華西醫院肝膽胰外科（成都 610041）;

關鍵詞：

胰腺星狀細胞胰腺纖維化慢性胰腺炎治療

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的介紹胰腺星狀細胞在胰腺纖維化中的作用及抗胰腺纖維化研究進展。
方法復習相關文獻資料并作綜述。
結果胰腺星狀細胞的活化與胰腺纖維化密切相關，抑制胰腺星狀細胞活化可為臨床治療慢性胰腺炎提供新的途徑。
結論胰腺星狀細胞是胰腺纖維化發病的關鍵環節，并逐漸成為抗胰腺纖維化及治療慢性胰腺炎的重要靶標。

引用本文： 鄭振江,向光明,劉續寶. 胰腺星狀細胞在胰腺纖維化中的作用. 中國普外基礎與臨床雜志, 2010, 17(8): 876-879. doi: 復制

1.	Masamune A, Shimosegawa T. Signal transduction in pancreatic stellate cells [J]. J Gastroenterol, 2009; 44(4): 249260.
2.	Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture [J]. Gut, 1998; 43(1): 128133.
3.	Saotome T, Inoue H, Fujimiya M, et al. Morphological and immunocytochemical identification of periacinar fibroblastlike cells derived from human pancreatic acini [J]. Pancreas, 1997; 14(4): 373382.
4.	Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis [J]. Am J Pathol, 1999; 155(4): 10871095.
5.	Shimizu K. Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis [J]. J Gastroenterol, 2008; 43(11): 823832.
6.	Jaster R, Emmrich J. Crucial role of fibrogenesis in pancreatic diseases [J]. Best Pract Res Clin Gastroenterol, 2008; 22(1): 1729.
7.	Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis [J]. Gut, 2002; 50(4): 535541.
8.	Aoki H, Ohnishi H, Hama K, et al. Existence of autocrine loop between interleukin6 and transforming growth factorβ1 in activated rat pancreatic stellate cells [J]. J Cell Biochem, 2006; 99(1): 221228.
9.	Schneider E, SchmidKotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells [J]. Am J Physiol Cell Physiol, 2001; 281(2): C532C543.
10.	Yadav D, Whitcomb DC. The role of alcohol and smoking in pancreatitis [J]. Nat Rev Gastroenterol Hepatol, 2010; 7 (3): 131145.
11.	Ohnishi N, Miyata T, Ohnishi H, et al. Activin A is an autocrine activator of rat pancreatic stellate cells: potential role of follistatin for pancreatic fibrosis [J]. Gut, 2003; 52(10): 14871493.
12.	Philipps PA, Wu MJ, Kumar RK, et al. Cell migration: a novel aspect of pancreatic stellate cell biology [J]. Gut, 2003; 52(5): 677682.
13.	Leung PS. The physiology of a local reninangiotensin system in the pancreas [J]. J Physiol, 2007; 580(Pt1): 3137.
14.	Reinehr R, Zoller S, KlonowskiStumpe H, et al. Effects of Angiotensin II on rat pancreatic stellate cells [J]. Pancreas, 2004; 28(2): 129137.
15.	Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dualspecificity protein phosphatases [J]. Oncogene, 2007; 26(22): 32033213.
16.	Jaster R, Sparmann G, Emmrich J, et al. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells [J]. Gut, 2002; 51(4): 579584.
17.	楊小艷, 鄭勇. Smad7對TGFβ/SMAD的調節及其在肝纖維化中的作用 [J]. 臨床肝膽胰雜志, 2007; 23(6): 467469.
18.	馬松林, 趙秋, 龔勇, 等. 纖維化胰腺組織中TGFβ1、Smad3、Smad7的表達及意義 [J]. 世界華人消化雜志, 2007; 15(2): 185188.
19.	Dooley S, Hamzavi J, Breitkopf K, et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats [J]. Gastroenterology, 2003; 125(1): 178191.
20.	McCarroll JA, Phillips PA, Kumar RK, et al. Pancreatic stellate cell migration: role of the phosphatidylinositol 3kinase (PI3kinase) pathway [J]. Biochem Pharmacol, 2004; 67(6): 12151225.
21.	Masamune A, Kikuta K, Satoh M, et al. Rho kinase inhibitors block activation of pancreatic stellate cells [J]. Br J Pharmacol, 2003; 140(7): 12921302.
22.	劉續寶. 慢性胰腺炎的診斷和治療 [J]. 中國普外基礎與臨床雜志, 2007; 14(4): 385387.
23.	Rockey DC, Maher JJ, Jarnagin WR, et al. Inhibition of rat hepatic lipocyte activation in culture by IFNγ [J]. Hepatology, 1992; 16(3): 776784.
24.	Baumert JT, Sparmann G, Emmrich J, et al. Inhibitory effect of interferons on pancreatic stellate cell activation [J]. World J Gastroenterol, 2006; 12(6): 896901.
25.	Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways [J]. Oncogene, 2000; 19(49): 56625679.
26.	黃茜, 陳少夫, 鄭宏. 干擾素α2b對胰腺纖維化大鼠Ⅲ型膠原和纖維連接蛋白表達的影響 [J]. 胰腺病學, 2007; 7(5): 326328.
27.	鮑華英, 陳榮華. 姜黃素的研究進展 [J]. 國際兒科學雜志, 2003; 30(5): 254256.
28.	Masamune A, Suzuki N, Kikuta K, et al. Curcumin blocks activation of pancreatic stellate cells [J]. J Cell Biochem, 2006; 97(5): 10801093.
29.	侯懿耕, 張園園, 賈潔, 等. 過氧化物酶體增殖物激活受體γ在肝星狀細胞靜止表型維持中的作用 [J]. 世界華人消化雜志, 2008; 16(33): 37653768.
30.	Van Westerloo DJ, Florquin S, deBoer AM, et al. Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice [J]. Am J Pathol, 2005; 166(3): 721728.
31.	Shimuzu K, Shiratori K, Kobayashi M, et al. Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPAR γindependent mechanism [J]. Pancreas, 2004; 29(1): 6774.
32.	Tahmasebi M, Puddefoot JR, Inwang ER, et al. The tissue reninangiotensin system in human pancreas [J]. J Endocrinol, 1999; 161(2): 317322.
33.	Kuno A, Yamada T, Masuda K, et al. Angiotensinconverting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats [J]. Gastroenterology, 2003; 124(4): 10101019.
34.	張汝玲, 劉文濱, 王興鵬, 等.Ⅰ型血管緊張素Ⅱ受體拮抗劑對胰腺星狀細胞的影響 [J]. 中華消化雜志, 2006; 26(9): 598601.
35.	Nathan JD, Romac J, Peng RY, et al. Protection against chronic pancreatitis and pancreatic fibrosis in mice over expressing pancreatic secretory trypsin inhibitor [J]. Pancreas, 2010; 39(1): e24e30.
36.	Su SB, Motoo Y, Iovanna JL, et al. Effect of camostat mesilate on the expression of PancreaticAssociated Protein (PAP), p8 and cytokines in rat spontaneous chronic pancreatitis [J]. Pancreas, 2001; 23(2): 134140.
37.	McCarroll JA, Phillips PA, Santucci N, et al. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis [J]. Gut, 2006; 55(1): 7989.
38.	Masamune A, Satoh M, Kikuta K, et al. Endothelin1 stimulates contraction and migration of rat pancreatic stellate cells [J]. World J Gastroenterol, 2005; 11(39): 61446151.
39.	羅璐, 于鋒, 戴德哉. 內皮素受體拮抗劑波生坦與其他藥物的相互作用 [J]. 藥學進展, 2007; 31(10): 452457.
40.	Fitzner B, Brock P, Holzhüter SA, et al. Synergistic growth inhibitory effects of the dual endothelin1 receptor antagonist bosentan on pancreatic stellate and cancer cells [J]. Dig Dis Sci, 2009; 54(2): 309320.

1. Masamune A, Shimosegawa T. Signal transduction in pancreatic stellate cells [J]. J Gastroenterol, 2009; 44(4): 249260.
2. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture [J]. Gut, 1998; 43(1): 128133.
3. Saotome T, Inoue H, Fujimiya M, et al. Morphological and immunocytochemical identification of periacinar fibroblastlike cells derived from human pancreatic acini [J]. Pancreas, 1997; 14(4): 373382.
4. Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis [J]. Am J Pathol, 1999; 155(4): 10871095.
5. Shimizu K. Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis [J]. J Gastroenterol, 2008; 43(11): 823832.
6. Jaster R, Emmrich J. Crucial role of fibrogenesis in pancreatic diseases [J]. Best Pract Res Clin Gastroenterol, 2008; 22(1): 1729.
7. Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis [J]. Gut, 2002; 50(4): 535541.
8. Aoki H, Ohnishi H, Hama K, et al. Existence of autocrine loop between interleukin6 and transforming growth factorβ1 in activated rat pancreatic stellate cells [J]. J Cell Biochem, 2006; 99(1): 221228.
9. Schneider E, SchmidKotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells [J]. Am J Physiol Cell Physiol, 2001; 281(2): C532C543.
10. Yadav D, Whitcomb DC. The role of alcohol and smoking in pancreatitis [J]. Nat Rev Gastroenterol Hepatol, 2010; 7 (3): 131145.
11. Ohnishi N, Miyata T, Ohnishi H, et al. Activin A is an autocrine activator of rat pancreatic stellate cells: potential role of follistatin for pancreatic fibrosis [J]. Gut, 2003; 52(10): 14871493.
12. Philipps PA, Wu MJ, Kumar RK, et al. Cell migration: a novel aspect of pancreatic stellate cell biology [J]. Gut, 2003; 52(5): 677682.
13. Leung PS. The physiology of a local reninangiotensin system in the pancreas [J]. J Physiol, 2007; 580(Pt1): 3137.
14. Reinehr R, Zoller S, KlonowskiStumpe H, et al. Effects of Angiotensin II on rat pancreatic stellate cells [J]. Pancreas, 2004; 28(2): 129137.
15. Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dualspecificity protein phosphatases [J]. Oncogene, 2007; 26(22): 32033213.
16. Jaster R, Sparmann G, Emmrich J, et al. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells [J]. Gut, 2002; 51(4): 579584.
17. 楊小艷, 鄭勇. Smad7對TGFβ/SMAD的調節及其在肝纖維化中的作用 [J]. 臨床肝膽胰雜志, 2007; 23(6): 467469.
18. 馬松林, 趙秋, 龔勇, 等. 纖維化胰腺組織中TGFβ1、Smad3、Smad7的表達及意義 [J]. 世界華人消化雜志, 2007; 15(2): 185188.
19. Dooley S, Hamzavi J, Breitkopf K, et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats [J]. Gastroenterology, 2003; 125(1): 178191.
20. McCarroll JA, Phillips PA, Kumar RK, et al. Pancreatic stellate cell migration: role of the phosphatidylinositol 3kinase (PI3kinase) pathway [J]. Biochem Pharmacol, 2004; 67(6): 12151225.
21. Masamune A, Kikuta K, Satoh M, et al. Rho kinase inhibitors block activation of pancreatic stellate cells [J]. Br J Pharmacol, 2003; 140(7): 12921302.
22. 劉續寶. 慢性胰腺炎的診斷和治療 [J]. 中國普外基礎與臨床雜志, 2007; 14(4): 385387.
23. Rockey DC, Maher JJ, Jarnagin WR, et al. Inhibition of rat hepatic lipocyte activation in culture by IFNγ [J]. Hepatology, 1992; 16(3): 776784.
24. Baumert JT, Sparmann G, Emmrich J, et al. Inhibitory effect of interferons on pancreatic stellate cell activation [J]. World J Gastroenterol, 2006; 12(6): 896901.
25. Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways [J]. Oncogene, 2000; 19(49): 56625679.
26. 黃茜, 陳少夫, 鄭宏. 干擾素α2b對胰腺纖維化大鼠Ⅲ型膠原和纖維連接蛋白表達的影響 [J]. 胰腺病學, 2007; 7(5): 326328.
27. 鮑華英, 陳榮華. 姜黃素的研究進展 [J]. 國際兒科學雜志, 2003; 30(5): 254256.
28. Masamune A, Suzuki N, Kikuta K, et al. Curcumin blocks activation of pancreatic stellate cells [J]. J Cell Biochem, 2006; 97(5): 10801093.
29. 侯懿耕, 張園園, 賈潔, 等. 過氧化物酶體增殖物激活受體γ在肝星狀細胞靜止表型維持中的作用 [J]. 世界華人消化雜志, 2008; 16(33): 37653768.
30. Van Westerloo DJ, Florquin S, deBoer AM, et al. Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice [J]. Am J Pathol, 2005; 166(3): 721728.
31. Shimuzu K, Shiratori K, Kobayashi M, et al. Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPAR γindependent mechanism [J]. Pancreas, 2004; 29(1): 6774.
32. Tahmasebi M, Puddefoot JR, Inwang ER, et al. The tissue reninangiotensin system in human pancreas [J]. J Endocrinol, 1999; 161(2): 317322.
33. Kuno A, Yamada T, Masuda K, et al. Angiotensinconverting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats [J]. Gastroenterology, 2003; 124(4): 10101019.
34. 張汝玲, 劉文濱, 王興鵬, 等.Ⅰ型血管緊張素Ⅱ受體拮抗劑對胰腺星狀細胞的影響 [J]. 中華消化雜志, 2006; 26(9): 598601.
35. Nathan JD, Romac J, Peng RY, et al. Protection against chronic pancreatitis and pancreatic fibrosis in mice over expressing pancreatic secretory trypsin inhibitor [J]. Pancreas, 2010; 39(1): e24e30.
36. Su SB, Motoo Y, Iovanna JL, et al. Effect of camostat mesilate on the expression of PancreaticAssociated Protein (PAP), p8 and cytokines in rat spontaneous chronic pancreatitis [J]. Pancreas, 2001; 23(2): 134140.
37. McCarroll JA, Phillips PA, Santucci N, et al. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis [J]. Gut, 2006; 55(1): 7989.
38. Masamune A, Satoh M, Kikuta K, et al. Endothelin1 stimulates contraction and migration of rat pancreatic stellate cells [J]. World J Gastroenterol, 2005; 11(39): 61446151.
39. 羅璐, 于鋒, 戴德哉. 內皮素受體拮抗劑波生坦與其他藥物的相互作用 [J]. 藥學進展, 2007; 31(10): 452457.
40. Fitzner B, Brock P, Holzhüter SA, et al. Synergistic growth inhibitory effects of the dual endothelin1 receptor antagonist bosentan on pancreatic stellate and cancer cells [J]. Dig Dis Sci, 2009; 54(2): 309320.

《中國普外基礎與臨床雜志》

胰腺星狀細胞在胰腺纖維化中的作用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

胰腺星狀細胞在胰腺纖維化中的作用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料