腹腔熱灌注化療毒副作用的觀察及分析_《中國普外基礎與臨床雜志》

作者：

劉義冰 ¹ , 劉巍 ¹ , 洪雷 ¹ , 董倩 ¹ , 陳瑞新 ²

１.河北醫科大學第四醫院腫瘤內科(石家莊 050011);;
２.廣東省順德北滘醫院和佳醫療設備公司(順德 528311);

關鍵詞：

腹腔熱灌注化療惡性腫瘤毒副作用

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目的觀察腹腔熱灌注化療(CHPPC)患者治療期間不良反應的發生情況。
方法采用B超引導下行腹腔穿刺置管術,穿刺置管后連接體腔熱灌注儀進行灌注治療,溫度控制在42～44 ℃,循環時間1 h,觀察患者體溫、心率、血壓、血氧飽和度及呼吸頻率的變化,同時觀察患者腹部及全身情況,如腹部壓痛、反跳痛等癥狀及體征。
結果本組109例腹盆腔惡性腫瘤患者術后1個月行CHPPC,灌注過程中體溫、心率、血壓、血氧飽和度及呼吸頻率變化與灌注前比較,差異均無統計學意義(P gt;0.05)。有25例患者出現腹痛,但僅3例患者出現類似急腹癥表現； 26例患者出現消化道反應； 20例患者出現骨髓抑制; 其他不良反應(22例)主要為穿刺處疼痛,給予對癥治療后緩解。
結論 CHPPC 選擇在手術后1個月時進行,毒副作用小,耐受性較好。

引用本文： 劉義冰,劉巍,洪雷,董倩,陳瑞新. 腹腔熱灌注化療毒副作用的觀察及分析. 中國普外基礎與臨床雜志, 2010, 17(3): 237-239. doi: 復制

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3.	Elias D, Sideris L, Pocard M, et al. Efficacy of intraperitoneal chemohyperthermia with oxaliplatin in colorectal peritoneal carcinomatosis. Preliminary results in 24 patients [J]. Ann Oncol, 2004; 15(5): 781785.
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9.	Shinginasa K, Ryuidi H, Michio M, et al. Prophylactic therapy for peritoneal recurrence of gastric cancer by CHIP with MMC [J]. Cancer, 1998; 61(2): 232233.
10.	Toyota N, Strebel FR, Stephens LC, et al. Effect of altered duration of 41.5 ℃ whole body hyperthermia in combination with cisdiamminedichloroplatinum (Ⅱ) on tumor and normal tissue apoptosis and tumor response in rats [J]. Oncol Rep, 1998; 5(5): 12311236.
11.	Raaphorst GP, Mao J, Yang H, et al. Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin [J]. Anticancer Res, 1998; 18(4C): 29452951.
12.	Othman T, Goto S, Lee JB, et al. Hyperthermic enhancement of the apoptotic and antiproliferative activities of paclitaxel [J]. Pharmacology, 2001; 62(4): 208212.
13.	Shen P, Levine EA, Hall J, et al. Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin C after cytoreductive surgery for patients with peritoneal carcinomatosis [J]. Arch Surg, 2003; 138(1): 2633.
14.	Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol, 2003; 21(20): 37373743.
15.	Glehen O, Osinsky D, Cotte E, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures [J]. Ann Surg Oncol, 2003; 10(8): 863869.

1. Fujimoto S, Shrestha RD, Kokubun M, et al. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding [J]. Ann Surg, 1988; 208(1): 3641.
2. Yonemura Y, de Aretxabala X, Fujimura T, et al. Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study [J]. Hepatogastroenterology, 2001; 48(42): 17761782.
3. Elias D, Sideris L, Pocard M, et al. Efficacy of intraperitoneal chemohyperthermia with oxaliplatin in colorectal peritoneal carcinomatosis. Preliminary results in 24 patients [J]. Ann Oncol, 2004; 15(5): 781785.
4. 周際昌. 實用腫瘤內科學 [M]. 第2版. 北京: 人民衛生出版社, 2000: 619625.
5. 孫燕, 石遠凱. 臨床腫瘤內科手冊 [M]. 第5版. 北京: 人民衛生出版社, 2008: 142143.
6. 張珊文, 尚衛群, 呂有勇. 抑癌基因p53提高人胃癌細胞熱敏感性的作用 [J].中華物理醫學和康復雜志, 2000; 22(2): 9496.
7. MoriyamaGonda N, Igawa M, Shiina H, et al. Heatinduced membrane damage combined with adriamycin on prostate carcinoma PC3 cells: correlation of cytotoxicity, permeability and Pglycoprotein or metallothionein expression [J]. Br J Urol, 1998; 82(4): 552559.
8. 張剛慶, 卿三華, 齊德林, 等. 腹腔或盆腔熱灌注化療的胃腸癌臨床研究50例 [J]. 中華普通外科雜志, 2001; 16(12): 737739.
9. Shinginasa K, Ryuidi H, Michio M, et al. Prophylactic therapy for peritoneal recurrence of gastric cancer by CHIP with MMC [J]. Cancer, 1998; 61(2): 232233.
10. Toyota N, Strebel FR, Stephens LC, et al. Effect of altered duration of 41.5 ℃ whole body hyperthermia in combination with cisdiamminedichloroplatinum (Ⅱ) on tumor and normal tissue apoptosis and tumor response in rats [J]. Oncol Rep, 1998; 5(5): 12311236.
11. Raaphorst GP, Mao J, Yang H, et al. Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin [J]. Anticancer Res, 1998; 18(4C): 29452951.
12. Othman T, Goto S, Lee JB, et al. Hyperthermic enhancement of the apoptotic and antiproliferative activities of paclitaxel [J]. Pharmacology, 2001; 62(4): 208212.
13. Shen P, Levine EA, Hall J, et al. Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin C after cytoreductive surgery for patients with peritoneal carcinomatosis [J]. Arch Surg, 2003; 138(1): 2633.
14. Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol, 2003; 21(20): 37373743.
15. Glehen O, Osinsky D, Cotte E, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures [J]. Ann Surg Oncol, 2003; 10(8): 863869.

《中國普外基礎與臨床雜志》

腹腔熱灌注化療毒副作用的觀察及分析

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《中國普外基礎與臨床雜志》

腹腔熱灌注化療毒副作用的觀察及分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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