淺析砂粒體在人體腫瘤中的形成機理及相關問題_《中國普外基礎與臨床雜志》

作者：

李曉龍 ^1,2 , 李志輝 ¹

1.四川大學華西醫院甲狀腺乳腺外科（成都 610041）;;
2.四川大學華西口腔醫學院（成都 610041）;

關鍵詞：

砂粒體鈣化甲狀腺乳頭狀癌腦膜瘤卵巢漿液性乳頭狀癌

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目的初步了解砂粒體在人體腫瘤中形成機理的研究的最新進展及與之相關的問題。方法參閱、分析、比較國內、外相關文獻，并進行歸納總結，再加以綜述。結果砂粒體是某些腫瘤組織中的特殊病理性鈣化，在顯微鏡下均呈同心圓層狀排列的鈣化灶,常見于甲狀腺乳頭狀癌、腦膜瘤、卵巢漿液性乳頭狀癌等。結論砂粒體雖在顯微鏡下均呈同心圓層狀排列的鈣化灶，但在不同的腫瘤中其形成過程卻不盡相同。全面客觀地認識砂粒體的形成將有助于對腫瘤的診斷、治療。

引用本文： 李曉龍,李志輝. 淺析砂粒體在人體腫瘤中的形成機理及相關問題. 中國普外基礎與臨床雜志, 2010, 17(11): 1216-1218. doi: 復制

1.	Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
2.	Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
3.	Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
4.	Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
5.	Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
6.	官青, 吳毅. 砂粒體在甲狀腺癌研究中的進展 [J]. 中國癌癥雜志， 2009； 19(8): 637-640.
7.	Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
8.	Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
9.	陳昊. 砂粒體在腫瘤中的形成與臨床意義 [J]. 河南腫瘤學雜志, 1999； 12(2): 148-149.
10.	Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
11.	Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
12.	Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
13.	范自平, 喬智, 吳德敬. 甲狀腺癌診斷及復發因素分析 [J]. 中國普外基礎與臨床雜志, 2010； 17(1): 68-72.
14.	Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
15.	Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
16.	Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
17.	趙文雯, 王長秋, 魯安懷，等. 甲狀腺乳頭狀癌中砂粒體礦物學研究 [J]. 巖石礦物學雜志, 2009； 28(6): 623-628.
18.	Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
19.	唐波, 姜軍. RET原癌基因與分化性甲狀腺癌關系的研究進展 [J]. 中國普外基礎與臨床雜志, 2004； 11(1): 89-91.
20.	Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
21.	Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
22.	楊若晨, 王長秋, 魯安懷, 等. 腦膜瘤中砂粒體礦化研究 [J]. 地學前緣, 2008； 15(06): 44-53.
23.	Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
24.	Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
25.	金曉明, 岡田英吉, 趙綱, 等. 人腦脈絡叢內砂粒體的免疫組織化學研究 [J]. 臨床與實驗病理學雜志, 1999； 15(1): 44-46.
26.	Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
27.	Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
28.	Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
29.	Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
30.	Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
31.	Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
32.	Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
33.	王長秋, 楊若晨, 魯安懷，等. 人體卵巢癌中砂粒體礦化的礦物學研究 [J]. 巖石礦物學雜志, 2009； 28(6): 617-622.
34.	Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
35.	Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
36.	Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.

1. Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
2. Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
3. Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
4. Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
5. Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
6. 官青, 吳毅. 砂粒體在甲狀腺癌研究中的進展 [J]. 中國癌癥雜志， 2009； 19(8): 637-640.
7. Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
8. Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
9. 陳昊. 砂粒體在腫瘤中的形成與臨床意義 [J]. 河南腫瘤學雜志, 1999； 12(2): 148-149.
10. Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
11. Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
12. Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
13. 范自平, 喬智, 吳德敬. 甲狀腺癌診斷及復發因素分析 [J]. 中國普外基礎與臨床雜志, 2010； 17(1): 68-72.
14. Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
15. Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
16. Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
17. 趙文雯, 王長秋, 魯安懷，等. 甲狀腺乳頭狀癌中砂粒體礦物學研究 [J]. 巖石礦物學雜志, 2009； 28(6): 623-628.
18. Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
19. 唐波, 姜軍. RET原癌基因與分化性甲狀腺癌關系的研究進展 [J]. 中國普外基礎與臨床雜志, 2004； 11(1): 89-91.
20. Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
21. Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
22. 楊若晨, 王長秋, 魯安懷, 等. 腦膜瘤中砂粒體礦化研究 [J]. 地學前緣, 2008； 15(06): 44-53.
23. Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
24. Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
25. 金曉明, 岡田英吉, 趙綱, 等. 人腦脈絡叢內砂粒體的免疫組織化學研究 [J]. 臨床與實驗病理學雜志, 1999； 15(1): 44-46.
26. Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
27. Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
28. Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
29. Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
30. Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
31. Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
32. Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
33. 王長秋, 楊若晨, 魯安懷，等. 人體卵巢癌中砂粒體礦化的礦物學研究 [J]. 巖石礦物學雜志, 2009； 28(6): 617-622.
34. Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
35. Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
36. Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.

《中國普外基礎與臨床雜志》

淺析砂粒體在人體腫瘤中的形成機理及相關問題

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