肝癌切除后的序貫綜合治療3例報道并文獻復習_《中國普外基礎與臨床雜志》

作者：

雷建勇 , 嚴律南 , 王文濤 , 徐明清 , 楊家印

四川大學華西醫院肝臟與血管外科（四川成都 610041）;

關鍵詞：

肝癌預防復發序貫綜合治療療效肝移植肝癌切除肝癌治療

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目的探討肝癌手術切除后的序貫綜合治療,以達到有效防治腫瘤復發的目的。方法從我科收治的肝癌患者中挑選3例手術治療后進行序貫綜合治療并取得良好效果病例，對其臨床資料進行分析，從中獲取有關肝癌術后治療的經驗。結果3例肝癌患者在我科手術后接受了積極的預防復發措施，雖最終均出現復發，但對待復發的腫瘤均采取積極的應對措施，獲得了長期生存。結論對于肝癌手術切除后的患者進行積極的序貫性綜合治療有較好的臨床意義，鼓勵對術后復發病例進行積極序貫綜合治療。

引用本文： 雷建勇,嚴律南,王文濤,徐明清,楊家印. 肝癌切除后的序貫綜合治療3例報道并文獻復習. 中國普外基礎與臨床雜志, 2011, 18(6): 654-656. doi: 復制

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13.	Ueno S, Kubo F, Sakoda M, et al. Efficacy of anatomic resection vs nonanatomic resection for small nodular hepatocellular carcinoma based on gross classification [J]. J Hepatobiliary Pancreat Surg, 2008, 15(5): 493500.
14.	Adam R, Del Gaudio M. Evolution of liver transplantation for hepatocellular carcinoma [J]. J Hepatol, 2003, 39(6): 888895.
15.	Sugawara Y, Kokudo N. Surgical treatment of hepatocellular carcinoma: comparison of resection and transplantation [J]. Oncology, 2008, 75 Suppl 1: 119123.
16.	楊廣順, 吳志全, 吳孟超. 原發性肝癌的規范化綜合治療 [J]．中華外科雜志， 2001， 39(10)： 742744.
17.	Seo DD, Lee HC, Jang MK, et al. Preoperative portal vein embolization and surgical resection in patients with hepatocellular carcinoma and small future liver remnant volume: comparison with transarterial chemoembolization [J]. Ann Surg Oncol, 2007, 14(12): 35013509.
18.	Abulkhir A, Limongelli P, Healey AJ, et al. Preoperative portal vein embolization for major liver resection: a metaanalysis [J]. Ann Surg, 2008, 247(1): 4957.
19.	Livraghi T, Solbiati L, Meloni MF, et al. Treatment of focal liver tumors with percutaneous radiofrequency ablation: complications encountered in a multicenter study [J]. Radiology, 2003, 226(2): 441451.
20.	姚和瑞, 謝德榮, 滕虹, 等. 高強度聚焦超聲熱療治療晚期原發性肝癌療效觀察 [J]. 新醫學, 2003, 34(5)： 303304.
21.	Lee J, Park JO, Kim WS, et al. Phase II study of doxorubicin and cisplatin in patients with metastatic hepatocellular carcinoma [J]. Cancer Chemother Pharmacol, 2004, 54(5): 385390.
22.	Ikeda M, Okusaka T, Ueno H, et al. A phase II trial of continuous infusion of 5fluorouracil, mitoxantrone, and cisplatin for metastatic hepatocellular carcinoma [J]. Cancer, 2005, 103(4): 756762.
23.	Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma [J]. Lancet, 2003, 362(9399): 19071917.

1. Llovet JM, Fuster J, Bruix J. Intentiontotreat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation [J]. Hepatology, 1999, 30(6): 14341440.
2. Choi GH, Kim DH, Kang CM, et al. Is preoperative transarterial chemoembolization needed for a resectable hepatocellular carcinoma? [J]. World J Surg, 2007, 31(12): 23702377.
3. Chen XP, Hu DY, Zhang ZW, et al. Role of mesohepatectomy with or without transcatheter arterial chemoembolization for large centrally located hepatocellular carcinoma [J]. Dig Surg, 2007, 24(3): 208213．.
4. Chau GY, Lui WY, Tsay SH, et al. Postresectional adjuvant intraportal chemotherapy in patients with hepatocellular carcinoma: a casecontrol study [J]. Ann Surg Oncol, 2006, 13(10): 13291337.
5. Marelli L, Stigliano R, Triantos C, et al. Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies [J]. Cancer Treat Rev, 2006, 32(8): 594606.
6. Jeong S, Aikata H, Katamura Y, et al. Lowdose intermittent interferonalpha therapy for HCVrelated liver cirrhosis after curative treatment of hepatocellular carcinoma [J]. World J Gastroenterol, 2007, 13(39): 51885195.
7. Lo CM, Hu CL, Chan SC, et al. A randomized controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma [J]. Ann Surg, 2007, 245(6): 831842．.
8. Dawson LA, Eccles C, Bissonnette JP, et al. Accuracy of daily image guidance for hypofractionated liver radiotherapy with active breathing control [J]. Int J Radiat Oncol Biol Phys, 2005, 62(4): 12471252.
9. 吳孟超. 中醫藥在肝癌防治中的作用、地位和存在的問題 [J]．中西醫結合學報, 2003, 1(3): 163164.
10. Mizuta T, Ozaki I, Eguchi Y, et al. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study [J]. Cancer, 2006, 106(4): 867872.
11. 李瑜元. 原發性肝癌的非手術治療 [J]．實用醫學雜志, 2003, 19(3): 231233．.
12. 樊嘉，黃成. 原發性肝癌外科治療的進展 [J]. 中國普外基礎與臨床雜志, 2009, 16(4): 257260.
13. Ueno S, Kubo F, Sakoda M, et al. Efficacy of anatomic resection vs nonanatomic resection for small nodular hepatocellular carcinoma based on gross classification [J]. J Hepatobiliary Pancreat Surg, 2008, 15(5): 493500.
14. Adam R, Del Gaudio M. Evolution of liver transplantation for hepatocellular carcinoma [J]. J Hepatol, 2003, 39(6): 888895.
15. Sugawara Y, Kokudo N. Surgical treatment of hepatocellular carcinoma: comparison of resection and transplantation [J]. Oncology, 2008, 75 Suppl 1: 119123.
16. 楊廣順, 吳志全, 吳孟超. 原發性肝癌的規范化綜合治療 [J]．中華外科雜志， 2001， 39(10)： 742744.
17. Seo DD, Lee HC, Jang MK, et al. Preoperative portal vein embolization and surgical resection in patients with hepatocellular carcinoma and small future liver remnant volume: comparison with transarterial chemoembolization [J]. Ann Surg Oncol, 2007, 14(12): 35013509.
18. Abulkhir A, Limongelli P, Healey AJ, et al. Preoperative portal vein embolization for major liver resection: a metaanalysis [J]. Ann Surg, 2008, 247(1): 4957.
19. Livraghi T, Solbiati L, Meloni MF, et al. Treatment of focal liver tumors with percutaneous radiofrequency ablation: complications encountered in a multicenter study [J]. Radiology, 2003, 226(2): 441451.
20. 姚和瑞, 謝德榮, 滕虹, 等. 高強度聚焦超聲熱療治療晚期原發性肝癌療效觀察 [J]. 新醫學, 2003, 34(5)： 303304.
21. Lee J, Park JO, Kim WS, et al. Phase II study of doxorubicin and cisplatin in patients with metastatic hepatocellular carcinoma [J]. Cancer Chemother Pharmacol, 2004, 54(5): 385390.
22. Ikeda M, Okusaka T, Ueno H, et al. A phase II trial of continuous infusion of 5fluorouracil, mitoxantrone, and cisplatin for metastatic hepatocellular carcinoma [J]. Cancer, 2005, 103(4): 756762.
23. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma [J]. Lancet, 2003, 362(9399): 19071917.

《中國普外基礎與臨床雜志》

肝癌切除后的序貫綜合治療3例報道并文獻復習

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《中國普外基礎與臨床雜志》

肝癌切除后的序貫綜合治療3例報道并文獻復習

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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