連環蛋白家族的新成員——p120-連環蛋白_《中國普外基礎與臨床雜志》

作者：

南潤玲 ¹ , 尚培中 ²

1.河北北方學院(河北張家口 075000);;
2.解放軍第251醫院普外科(河北張家口 075000);

關鍵詞：

p120-連環蛋白細胞黏附惡性腫瘤

視頻：

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目的介紹連環蛋白家族新成員p120-連環蛋白(p120-catenin，p120ctn)及其在腫瘤研究中的進展。方法查閱近年來國內、外有關對p120ctn研究的文獻并作綜述。結果①p120ctn參與鈣黏蛋白連環蛋白復合體的形成，參與細胞生長、增殖和黏附連接; ②調控Rho GTP 酶的活性，促進細胞運動性; ③與核內轉錄因子Kaiso結合形成Kaiso-p120ctn復合體，參與基因轉錄的調控; ④參與血管內皮生長因子誘導的血管新生過程; ⑤參與炎癥、細胞惡變以及腫瘤侵襲、轉移過程。結論p120ctn作為連環蛋白家族中的一個新成員，依靠它的細胞定位參與多種生物過程，從分子水平深入了解p120ctn的生物學功能及作用機理，有利于從p120ctn的異常改變判斷腫瘤的發生和發展，為腫瘤的預防和治療提供新的手段。

引用本文： 南潤玲,尚培中. 連環蛋白家族的新成員——p120-連環蛋白. 中國普外基礎與臨床雜志, 2011, 18(4): 462-467. doi: 復制

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3. 歐海玲, 覃宇周, 張錫流. Ecadherin/p120ctn與腫瘤關系的研究進展 [J]. 中國臨床新醫學, 2009, 2(2): 201205.
4. Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
5. Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
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7. Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
8. SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
9. Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
10. Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
11. Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
12. Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
13. Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
14. Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
15. Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
16. Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
17. Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
18. Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
19. Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
20. 羅小華, 劉文勵. P120ctn在血管內皮生長因子誘導血管生成中的作用 [J]. 臨床血液學雜志, 2006, 19(1): 5456.
21. Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
22. Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
23. van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
24. 黃華藝, 農朝贊, 郭凌宵, 等. 肝癌細胞生物學行為改變涉及p120ctn酪氨酸磷酸化的研究 [J]. 中華醫學雜志, 2003, 83(20): 18011806.
25. Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
26. 農朝贊, 黃嬋娟, 潘莉莉, 等. β連環蛋白在轉染p120ctn同工蛋白3A的肝癌細胞中的表達變化 [J]. 臨床與實驗病理學雜志, 2008, 24(6): 712715.
27. Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
28. 張毅, 朱瑾, 楊占宇, 等. 連環蛋白P120在肝細胞癌中的表達及其意義 [J]. 消化外科, 2006, 5(6): 431434.
29. Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
30. Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
31. Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
32. 虞志強. CDX2和p120catenin在胃癌組織中的臨床意義 [J]. 實用癌癥雜志, 2009, 24(6): 573575.
33. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer [J]. Biochim Biophys Acta, 2003, 1653(1): 124.
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《中國普外基礎與臨床雜志》

連環蛋白家族的新成員——p120-連環蛋白

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《中國普外基礎與臨床雜志》

連環蛋白家族的新成員——p120-連環蛋白

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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摘要全文圖表視頻參考文獻施引文獻補充材料