胃動素在胃癌組織中的表達及其意義_《中國普外基礎與臨床雜志》

作者：

王宏波 ^1,2 , 徐珞 ¹

1.青島大學醫學院病理生理教研室(山東青島 266021);;
2.墨市人民醫院胃腸外科(山東即墨 266200);

關鍵詞：

胃癌癌旁組織胃動素表達免疫組化

視頻：

導出 下載 收藏 掃碼 引用

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目的檢測胃動素在胃癌組織中的表達并探討其與胃癌臨床病理特征的關系。方法采用免疫組化SP法檢測胃癌、癌旁及正常胃黏膜組織中胃動素蛋白的表達，對胃癌組織中胃動素蛋白的表達及其與胃癌臨床病理特征之間的關系進行分析。結果胃癌組織中胃動素蛋白表達水平(1 206.43±631.67)明顯高于正常胃黏膜組織(890.55±98.67)和癌旁組織(922.75±265.99)，P lt;0.01，而癌旁組織和正常胃黏膜組織中胃動素蛋白表達水平的差異無統計學意義(P gt;0.05)。胃動素蛋白表達與腫瘤部位、腫瘤分化程度及淋巴結轉移有關(P lt;0.05)。結論胃動素可能參與胃癌的發生，并與胃癌的侵襲和轉移相關。

引用本文： 王宏波,徐珞. 胃動素在胃癌組織中的表達及其意義. 中國普外基礎與臨床雜志, 2011, 18(2): 183-186. doi: 復制

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5.	Ito M, Tanaka S, Maeda M, et al. Role of the gastringastrin receptor system in the expansive growth of human gastric neoplasms [J]. Digestion, 2008, 78(23): 163170.
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13.	Xu L, Depoortere I, Tang M, et al. Identification and expression of the motilin precursor in the guinea pig [J]. FEBS Lett, 2001, 490(12): 710.
14.	Xu L, Depoortere I, Tomasetto C, et al. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus [J]. Regul Pept, 2005, 124(13): 119125.
15.	Takeshita E, Matsuura B, Dong M, et al. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract [J]. J Gastroenterol, 2006, 41(3): 223230.
16.	Ter Beek WP, Muller ES, van den Berg M, et al. Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine [J]. Inflamm Bowel Dis, 2008, 14(5): 612619.
17.	Ozaki K, Yogo K, Sudo H, et al. Effects of mitemcinal (GM611), an acidresistant nonpeptide motilin receptor agonist on the gastrointestinal contractile activity in conscious dogs [J]. Pharmacology, 2007, 79(4): 223235.
18.	McCallum RW, Cynshi O. Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesisa randomized, multicentre, placebocontrolled study [J]. Aliment Pharmacol Ther, 2007, 26(8): 11211130.
19.	De Smet B, Mitselos A, Depoortere I. Motilin and ghrelin as prokinetic drug targets [J]. Pharmacol Ther, 2009, 123(2): 207223.
20.	Trudel L, Tomasetto C, Rio MC, et al. Ghrelin/motilinrelated peptide is a potent prokinetic to reverse gastric postoperative ileus in rat [J]. Am J Physiol Gastrointest Liver Physiol, 2002, 282(6): G948G952.
21.	鄧鋼明, 袁慶豐. 胃癌患者血漿胃動素與胃收縮運動的關系探討 [J]. 蚌埠醫學院學報, 2001, 26(3): 245.
22.	龍憲和. 胃腸肝等癌癥患者血漿胃動素觀察的臨床意義 [J]. 標記免疫分析與臨床, 2003, 10(3): 181182.
23.	呂賓, 葉再元, 朱林喜, 等．胃癌組織及癌區動、靜脈血胃腸激素的研究 [J]. 世界華人消化雜志, 2000, 8(12): 14291430.
24.	楊小慧, 劉勇剛, 陳海鷹, 等. 消化道腫瘤患者化療前后血漿胃動素和降鈣素基因相關肽的變化 [J]. 中國基層醫藥, 2008, 15(1): 2021.
25.	劉建平. 化濁解毒湯對慢性萎縮性胃炎大鼠MTL、SS、ET的影響 [D]. 河北: 河北醫科大學, 2009: 2639.

1. Cunningham SC, Kamangar F, Kim MP, et al. Claudin4, mitogenactivated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions [J]. Cancer Epidemiol Biomarkers Prev, 2006, 15(2): 281287.
2. Konturek PC, Kania J, Konturek JW, et al. H. pylori infection, atrophic gastritis, cytokines, gastrin, COX2, PPAR γ and impaired apoptosis in gastric carcinogenesis [J]. Med Sci Monit, 2003, 9(7): SR53SR66.
3. Hu C, Yi C, Hao Z, et al. The effect of somatostatin and SSTR3 on proliferation and apoptosis of gastric cancer cells [J]. Cancer Biol Ther, 2004, 3(8): 726730.
4. Matsubara J, Yamada Y, Nakajima TE, et al. Clinical significance of insulinlike growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer [J]. Oncology, 2008, 74(12): 7683.
5. Ito M, Tanaka S, Maeda M, et al. Role of the gastringastrin receptor system in the expansive growth of human gastric neoplasms [J]. Digestion, 2008, 78(23): 163170.
6. 葉序卷, 王立. 胃癌與相關胃腸激素的關系研究進展 [J]. 國際消化病雜志, 2006, 26(4): 253256.
7. Maev IV, Mel’nikova EV, Kashin SV, et al. Serologic screening for preneoplastic pathology and early stomach cancer [J]. Klin Med (Mosk), 2008, 86(11): 4348.
8. Kamerling IM, Van Haarst AD, Burggraaf J, et al. Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers [J]. Am J Physiol Gastrointest Liver Physiol, 2003, 284(5): G776G781.
9. Sanger GJ. Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases [J]. Drug Discov Today, 2008, 13(56): 234239.
10. Pendleton H, Ekman R, Olsson R, et al. Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus [J]. Eur J Intern Med, 2009, 20(6): 654659.
11. National Comprehensive Cancer Network. NCCN胃癌臨床實踐指南（中國版）專家組. 胃癌臨床實踐指南(中國版) [S]. 2009： 20.
12. Itoh Z. Motilin and clinical application [J]. Peptides, 1997, 18(4): 593608.
13. Xu L, Depoortere I, Tang M, et al. Identification and expression of the motilin precursor in the guinea pig [J]. FEBS Lett, 2001, 490(12): 710.
14. Xu L, Depoortere I, Tomasetto C, et al. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus [J]. Regul Pept, 2005, 124(13): 119125.
15. Takeshita E, Matsuura B, Dong M, et al. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract [J]. J Gastroenterol, 2006, 41(3): 223230.
16. Ter Beek WP, Muller ES, van den Berg M, et al. Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine [J]. Inflamm Bowel Dis, 2008, 14(5): 612619.
17. Ozaki K, Yogo K, Sudo H, et al. Effects of mitemcinal (GM611), an acidresistant nonpeptide motilin receptor agonist on the gastrointestinal contractile activity in conscious dogs [J]. Pharmacology, 2007, 79(4): 223235.
18. McCallum RW, Cynshi O. Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesisa randomized, multicentre, placebocontrolled study [J]. Aliment Pharmacol Ther, 2007, 26(8): 11211130.
19. De Smet B, Mitselos A, Depoortere I. Motilin and ghrelin as prokinetic drug targets [J]. Pharmacol Ther, 2009, 123(2): 207223.
20. Trudel L, Tomasetto C, Rio MC, et al. Ghrelin/motilinrelated peptide is a potent prokinetic to reverse gastric postoperative ileus in rat [J]. Am J Physiol Gastrointest Liver Physiol, 2002, 282(6): G948G952.
21. 鄧鋼明, 袁慶豐. 胃癌患者血漿胃動素與胃收縮運動的關系探討 [J]. 蚌埠醫學院學報, 2001, 26(3): 245.
22. 龍憲和. 胃腸肝等癌癥患者血漿胃動素觀察的臨床意義 [J]. 標記免疫分析與臨床, 2003, 10(3): 181182.
23. 呂賓, 葉再元, 朱林喜, 等．胃癌組織及癌區動、靜脈血胃腸激素的研究 [J]. 世界華人消化雜志, 2000, 8(12): 14291430.
24. 楊小慧, 劉勇剛, 陳海鷹, 等. 消化道腫瘤患者化療前后血漿胃動素和降鈣素基因相關肽的變化 [J]. 中國基層醫藥, 2008, 15(1): 2021.
25. 劉建平. 化濁解毒湯對慢性萎縮性胃炎大鼠MTL、SS、ET的影響 [D]. 河北: 河北醫科大學, 2009: 2639.

《中國普外基礎與臨床雜志》

胃動素在胃癌組織中的表達及其意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

胃動素在胃癌組織中的表達及其意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料