摘要:目的:探討肝素在預防過敏性紫癜性腎炎中的療效及安全性。方法:采用隨機對照的方法,將98例過敏性紫癜患兒分為肝素治療組(49例)和對照組(49例),肝素組給予肝素鈉100～150 Ｕ加入5%葡萄糖100～200 mL中靜脈點滴,每日1次,連用5～7天,以后每兩周查尿常規1次,至少觀察3個月或以上。結果:肝素治療組發生腎炎3例(6.1%),對照組發生腎炎11例(22.4%),肝素治療組腎炎發生率低于對照組(0.01 lt;P≤0.05)。結論:肝素對預防紫癜性腎炎的發生有效,且不良反應少。
Abstract: Objective: To investigate the heparin in the prevention of allergic purpura nephritis in the efficacy and safety. Methods:A randomizedcontrolled method, 98 cases of allergic purpura patients were divided into heparin in the treatment group (49 cases) and control group (49 cases), heparin group received heparin, 100150 u in 5% glucose 100 ~ 200 mL in the intravenous drip, day 1, used in conjunction 57 days, after a routine urine check every two weeks times, at least for 3 months or more.Results: The results of heparin treatment group occurred nephritis in 3 cases (6.1%), glomerulonephritis in 11 cases in control group (22.4%), glomerulonephritis incidence of heparin in the treatment group than the control group (0.01 lt;P ≤ 0.05). Conclusion: heparin in preventing the occurrence of HenochSchonlein purpura nephritis and effective, and less adverse reactions.

Citation： LIU TaiBin.. Heparin Treatment of Allergic Purpura Nephritis the Clinical Efficacy and Safety Study. West China Medical Journal, 2009, 24(11): 2934-0935. doi: Copy

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