摘要:目的:了解血肌酐清除率受損是否與冠心病患病率存在聯系。方法:納入2006年7月至2008年2月期間經冠狀動脈造影證實的冠心病患者及年齡、性別匹配的對照組,按血肌酐清除率值將患者分為正常［≥90 mg/（mL·173 m2)］,輕度受損［≥60 mg/（mL·1.73 m2）, lt;90 mg/（mL·1.73 m2)］和明顯受損［ lt;60 mg/（mL·1.73 m2)］。比較冠心病組與對照組各組人群的比例有無差異。結果:研究期間共納入冠心病組和對照組患者各116例。在冠心病組中,血肌酐清除率正常患者82例、輕度受損29例、重度受損5例,對照組中,正常患者98例、輕度受損13例、重度受損5例,〖JP3〗兩組比較分布有統計學差異(χ2值7.517,P=0.023)。與對照組比較,冠心病組的血清肌酐值無明顯差異（P gt;005)，〖JP〗冠心病組（103.29±51.08） μmol/L,對照組（102.67±41.21）μmol/L。結論:血肌酐清除率降低是冠心病的危險因素。
Abstract: Objective: To disclose the relation of the estimated glomerular filtration rate (eGFR) and coronary artery disease. Methods：We analyzed eGFR in the patients with coronary artery disease confirmed by coronary angiography and the control, and compared the proportion of patients with reduced renal function in the different groups. Results: A total 116 cases were included in each group. Among these patients, normal renal function, mildly and severe reduced renal function was documented in 82, 29 and 5 in coronary artery disease group, and in 98, 13 and 5 in the control group, respectively. In comparison to the control, more patients with reduced eGFR were found in coronary artery disease group (χ2 value 7.517,P=0.023), although no significant difference was observed between both groups（P gt;0.05). Conclusion: Reduced eGFR, even if mildly, could be regarded as the risk factor of coronary artery disease.

引用本文： 霍暢,楊泉,凌止鴻,晉強. 血肌酐清除率與冠心病關系分析. 華西醫學, 2009, 24(11): 2832-2833. doi: 復制