A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression_West China Medical Journal

Authors：

XIA Nan , FAN Wenlan , WANG Haiyan.

the Psychiatry Department of Mental Health Center of Nantong, Nanchong Sichuan 637000, China;

Corresponding?author：

Keywords：

抗抑郁劑; 心理干預; 心血管疾病; 焦慮抑郁

Video：

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目的:探討氟西汀聯合心理干預治療心血管疾病患者伴焦慮抑郁癥狀的臨床療效。方法:選擇伴有抑郁、焦慮情緒障礙的85例冠心病患者(心功能Ⅱ、Ⅲ級),并將其隨機分成研究組和對照組。觀察6w,對照組患者僅給予常規的治療,研究組患者在常規治療基礎上給予氟西汀聯合心理干預治療。觀察治療前后兩組患者采用漢密頓焦慮量表( Hamilton Anxiety Scale,HAMA) 評定焦慮癥狀,漢密頓抑郁量表( Hamilton Depression Scale,HAMD) 評定抑郁癥狀;并對治療后心功能分級(NYHA)恢復到Ⅰ級的例數及左室射血分數進行分析評價。結果:治療6 周后,研究組均較對照組的漢密頓焦慮量表及漢密頓抑郁量表評分下降顯著( P lt;0.01),研究組抗焦慮顯效率為87.16%、抗抑郁顯效率為82.26%,對照組分別為43.75%、45.36%,研究組均顯著高于對照組( P lt;0.01);研究組患者的左室射血分數顯著高于對照組 ( P lt;0.05),心功能分級(NYHA)恢復到Ⅰ級的例數顯著高于對照組 ( P lt;0.05)。結論:氟西汀聯合心理干預治療不僅能改善心血管疾病伴焦慮抑郁患者的焦慮、抑郁情緒障礙,還能改善患者的心功能,療效顯著優于單用心血管藥物治療。

Citation： XIA Nan,FAN Wenlan,WANG Haiyan.. A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression. West China Medical Journal, 2009, 24(10): 2511-2513. doi: Copy

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7.	GUMP B B, MATTHEWS K A, EBERLY L E, et al. Depression symptoms and mortality in men: Results from the multiple risk factor intervention trial[J]. Stroke, 2005(1), 36: 98-102.
8.	付朝偉, 徐飚, 欒榮生,等. 大城市綜合醫院冠心病人抑郁/ 焦慮影響因素探討[J]. 衛生研究, 2006, 35(5):634-636.
9.	THURSTON RC, KUBZANSKY LD, KAWACHI I, et al . Do depression and anxiety mediate the link between educational attainment and CHD [J]. Psychosomatic Medicine, 2006, 68(1):25-32.
10.	BLUMENTAL WA, GOMEZCAMINERO A, RUSSO LJ, et al . Does panic disorder increase the risk of coronary heart disease? [J]. Psychosomatic Medicine, 2005, 67(5):688-691.
11.	乙伶, 姚淮芳. 抑郁與冠心病發病機制最新研究進展[J]. 中西醫結合心腦血管病雜志2007, 5(10): 984-987.

1.
2. KOP W J, ADER D N. Assessment and treatment of depression in coronary artery disease patients[J]. Ital Heart J,2001,2(12):890-894.
3. THORNTON L A. Depression in postacute myocardial infarction patients [J]. J Am Acad Nurse Pract,2001,13(8):364-367.
4. 黃佐,樊民,吳宗貴.冠心病患者抑郁與冠狀動脈病變的關系[J].中華心血管病雜志,2003,31(5):329.
5. 陳銀娣,周天骍,施慎遜,等.老年冠心病病人焦慮、抑郁癥狀的調查[J].上海精神醫學,2000,12(1):17-19.
6. PENNIX B W, BEEKMAN AARTJAN T F, HONIG ADRIAAN MD, et al . Depression and cardiac mortality:Results from a communitybased longitudinal study[J]. Arch Gen Psychiatry,2001,58(3):221-227.
7. GUMP B B, MATTHEWS K A, EBERLY L E, et al. Depression symptoms and mortality in men: Results from the multiple risk factor intervention trial[J]. Stroke, 2005(1), 36: 98-102.
8. 付朝偉, 徐飚, 欒榮生,等. 大城市綜合醫院冠心病人抑郁/ 焦慮影響因素探討[J]. 衛生研究, 2006, 35(5):634-636.
9. THURSTON RC, KUBZANSKY LD, KAWACHI I, et al . Do depression and anxiety mediate the link between educational attainment and CHD [J]. Psychosomatic Medicine, 2006, 68(1):25-32.
10. BLUMENTAL WA, GOMEZCAMINERO A, RUSSO LJ, et al . Does panic disorder increase the risk of coronary heart disease? [J]. Psychosomatic Medicine, 2005, 67(5):688-691.
11. 乙伶, 姚淮芳. 抑郁與冠心病發病機制最新研究進展[J]. 中西醫結合心腦血管病雜志2007, 5(10): 984-987.

West China Medical Journal

A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression

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