缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞綜合征影響的研究_《華西醫學》

作者：

曾燕 ¹ , 江景 ¹ , 王玉 ²

1成都鐵路中心醫院婦產科,四川成都 610081; 2成都體育學院運動醫學系,四川成都 610041;

關鍵詞：

手術后疲勞綜合征缺氧預處理超氧化物歧化酶丙二醛

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目的:研究缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞是否有改善作用,并通過對比觀察超氧化物歧化酶及丙二醛水平的變化,初步探討缺氧預處理的作用機制。方法:將老年大鼠分為空白對照組、對照組、缺氧預處理三組。空白對照組為假手術組,對照組為子宮及雙附件切除術組, 缺氧預處理組為缺氧預處理加子宮及雙附件切除術組。對比觀察缺氧預處理對大鼠體力活動及血清超氧化物歧化酶和丙二醛水平的影響。結果:空白對照組、對照組、缺氧預處理三組大鼠懸尾不動時間分別為:(21±3)s,(83±10)s,(44±5)s,各組間比較P lt;0.05。三組SOD活性分別為:(131.23±5.31)U/L,(36.12±9.68)U/L,(73.01±9.82)U/L,各組間比較P lt;0.05。三組MDA水平分別為:(9.78±1.26)μmol/L,(29.87±3.13)μmol/L,(15.98±2.21)μmol/L,各組間比較P lt;0.05。結論:缺氧預處理可提高老年大鼠的抗氧化能力,對老年大鼠子宮及雙附件切除術后疲勞綜合征有明顯的改善作用。

引用本文： 曾燕,江景,王玉. 缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞綜合征影響的研究. 華西醫學, 2009, 24(8): 2095-2097. doi: 復制

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1. RUBIN G J, HOTOPF M. Systematic review and metaanalysis of interventions for postoperative fatigue[J]. Br J Surg,2002,89(8):971-984.
2. MURRY C E, JENNING R B, REIMER K A. Preconditioning with ischmia: a delay of cell injury in ischemic myocardium[J]. Circulation,1986,74(5):1124-1136.
3. CHRISTENSEN T, KEHLET H. Postoperative fatigue[J].World J Surg,1993,17(2):220-225.
4. SALMON P, HALL G M. A theory of postoperative fatigue[J]. J R Soc Med,1997,90(12):661-664.
5. TSUTUI H. Oxidative stress in heart failure: the role of mitochondria[J]. Intern Med,2001,40 (12): 1177-1182.
6. CHANDRA M, SURENDRA K, KAPOOR R K, et al. Oxidant stress mechanisms in heart failure[J]. Boll Chim Farm,2000,139(3):149-152.
7. GLOSLI H, TRONSTAD K J, WERGEDAL H, et al. Human TNFα in transgenic mice induces differential changes in redox status and glutathioneregulating enzymes[J]. FASEB J,2002,16(11):1450-1452.
8. MALAPLATEARMAND C, GUEGUEN Y, BERTRAND P, et al. U373MG response to interleukin1βinduced oxidative stress[J]. Cell Biol Toxicol,2000,16(3):155-163.
9. IHNKEN K, WINKLERA, SCHLENSAK C, et al. Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult[J]. J Thorac Cardiovasc Surg,1998,116(2):327-334.

《華西醫學》

缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞綜合征影響的研究

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《華西醫學》

缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞綜合征影響的研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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