皮質激素聯用環孢素防治穿透性角膜移植術后排斥反應的meta分析_《華西醫學》

作者：

四川大學華西醫院藥劑科,四川成都 610041;

關鍵詞：

環孢素皮質激素穿透性角膜移植 meta分析

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目的:評價皮質激素聯合環孢素對比皮質激素單用防治穿透性角膜移植(PKP)術后排斥反應的療效。方法:計算機檢索PubMed,EMBASE.com,SCI,Cochrane圖書館,CBM,CNKI數據庫,納入皮質激素聯用環孢素對比皮質激素單用防治PKP術后排斥反應的隨機對照試驗,進行方法學質量評價并應用RevMan軟件進行meta分析。結果:共納入5篇報道,1篇A級文獻,B、C級各2篇。Meta結果:術后排斥反應發生情況組間差異有統計學意義(RR=0.3,95%CI 0.140.65);對既發排斥反應的逆轉,組間差異無統計學意義(RR=1.15,95%CI 0.93-1.42)。結論:基于當前證據,皮質激素聯合環孢素防治PKP術后排斥反應療效并不優于皮質激素單用。

引用本文： 吳斌,蘇娜,程凱,胡海波,柳汝明,唐堯. 皮質激素聯用環孢素防治穿透性角膜移植術后排斥反應的meta分析. 華西醫學, 2009, 24(6): 1365-1368. doi: 復制

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1. WILLIAMS K A, LOWE M T, BARLETT C M, et al. Report from the Australian Corneal Graft Registry[M]. Flinders University Press,2007.
2. MAUREEN G M, WALTER J S, JOHN D G, et al. Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies [J]. Ophthalmology,1994,101:15361547.
3. JUNI P, ALTMAN D G, EGER M. Assessing the quality of controlled clinical trials [J]. BMJ,2001,323:42-46.
4. HIGGINS J P T, THOMPSON S G. Quantifying heterogeneity in a metaanalysis [J]. Stat Med,2002,21(11):1539-1558.
5. UNAL M, YUCEL I. Evaluation of topical ciclosporin 005% for prevention of rejection in highrisk corneal grafts [J]. Br J Ophthalmol,2008,92(10):1411-1414.
6. POON A, CONSTANTINOU M, LAMOUREUX E, et al. Topical Cyclosporin A in the treatment of acute graft rejection: a randomized controlled trial [J]. Clin Experiment Ophthalmol,2008,36(5):415-421..
7. NEJABAT M, KHOSHGHADAM J, EGHTEDARI M, et al. Topical cyclosporine A in corneal graft rejection [J]. Am J Immunol,2006,2(2):29-34.
8. 席興華,秦波,姜德詠,等.環孢霉素A和地塞米松防治穿透性角膜移植術后排斥反應的臨床觀察[J].中南大學學報,2003,28(6):627-630.
9. 賀焱,孫秉基,李玉淳,等.環孢霉素A滴眼預防高危角膜移植免疫排斥的效果[J].眼外傷職業眼病雜志,1999,21(5):420-421.
10. HILL J C. Systemic cyclosporine in highrisk keratoplasty: longterm results[J]. Eye,1995,9(Pt4):422-428.

《華西醫學》

皮質激素聯用環孢素防治穿透性角膜移植術后排斥反應的meta分析

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《華西醫學》

皮質激素聯用環孢素防治穿透性角膜移植術后排斥反應的meta分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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