Observation of the Effect of Metformin Combined with Clomiphene on Polycysticovary Syndrome_West China Medical Journal

Authors：

LI Yaqi

The First Autonomous Region Hospital of Liangshan, Liangshan Sichuan 615000, China;

Corresponding?author：

Keywords：

二甲雙胍; 克羅米芬; 多囊卵巢綜合征

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目的:探討二甲雙胍合并克羅米芬在治療多囊卵巢綜合征中的作用,為多囊卵巢綜合征的治療提供合理依據。方法:80例患者給予二甲雙胍合并克羅米芬治療,比較治療前后臨床癥狀、內分泌和生化指標的變化情況,與單一給予克羅米芬促排卵治療比較排卵、妊娠情況。結果:用藥后體重指數(BMI)、腰臀比(WHR)、空腹胰島素(FINS)、睪酮(T)促黃體生成素(LH)、LH/FSH明顯下降,P lt;0.05;雌二醇(E2)、促卵泡生成素(FSH)改變不明顯,聯合用藥后排卵、妊娠率明顯高于單一克羅米芬治療,P lt;0.05。結論:二甲雙胍合并克羅米芬可改善臨床癥狀,提高排卵、妊娠率,降低LH/FSH比值、LH、T水平,提高胰島素的敏感性。

Citation： LI Yaqi. Observation of the Effect of Metformin Combined with Clomiphene on Polycysticovary Syndrome. West China Medical Journal, 2009, 24(5): 1244-1246. doi: Copy

1.	ROTTERD A M, ESHRE/ASRM, SPONSOR E D, et al. Revised2003consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome[J]. Fertil Steril,2004,81(1):19-25.
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6.	MITWDLY M F. Casper Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate[J].Fertil Steril, 2001,75(2):305-309.
7.	DE LEO V, LAMACA A, DITTO A, et al.Effects of metformin on gonadotropin induced ovulation women with polycystic ovary syndrome[J]. Fertil Steril,1999,72(2):282285.
8.	GLUECK C J, WANG P, KOBAYASHI S, et al. Metformin therapy throughout pregnancy reduces the development of diabetes gestat ioncal diabetes in women with polycystic ovary syndrome[J]. Fertil Steril,2002,77(3):520-525.

1. ROTTERD A M, ESHRE/ASRM, SPONSOR E D, et al. Revised2003consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome[J]. Fertil Steril,2004,81(1):19-25.
2. MARX T L, MEHTA A E. Polycystic ovary syndrome: pathogene and treatment over the short and long term[J]. Clever Clin JM ed,2003,70(1):31.
3. KACALSKA O, KRZYCZKOWSKASENDRAKOWSKA M, MILEWICZ T. Molecular action of insulinsensitizing agents[J]. Endokrynol Pol,2005,56(3):308-313.
4. 陳小玲,黃水蓮. 多囊卵巢綜合征的研究進展[J]. 中國誤診學雜志,2007,15(7):3459-3461.
5. 翟軍,阮祥燕. 二甲雙胍治療多囊卵巢綜合征有效性相關因素的探討[J].實用婦產科雜志,2007,23(2):94-97.
6. MITWDLY M F. Casper Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate[J].Fertil Steril, 2001,75(2):305-309.
7. DE LEO V, LAMACA A, DITTO A, et al.Effects of metformin on gonadotropin induced ovulation women with polycystic ovary syndrome[J]. Fertil Steril,1999,72(2):282285.
8. GLUECK C J, WANG P, KOBAYASHI S, et al. Metformin therapy throughout pregnancy reduces the development of diabetes gestat ioncal diabetes in women with polycystic ovary syndrome[J]. Fertil Steril,2002,77(3):520-525.

West China Medical Journal

Observation of the Effect of Metformin Combined with Clomiphene on Polycysticovary Syndrome

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