Experimental Observation of Alcohol Extractive of Folium Eucommiae on the Rats with Hyperlipidemia Fatty Liver_West China Medical Journal

Authors：

JIANG Yuanming ¹ , LIU Yingju ² , WANG Menghua ² , et al. ²

1Suining Center Hospital, Suining Sichuan 629000; 2Department of Pharmacology, Chongqing University of Medical Sciences, Chongqing 400016, China;

Corresponding?author：

Keywords：

杜仲葉; 脂肪肝; 氧化應激; 腫瘤壞死因子α

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摘要:目的:通過建立高脂血癥脂肪肝動物模型,探討杜仲葉醇提取物(alcohol extractive of Folium Eucommiae,AEFE)對脂肪肝的防治作用。方法:高脂飲食8周加維生素D36×105IU/kg分3d腹腔注射，建立大鼠高脂血癥脂肪肝動物模型。各給藥組從造模第3周開始分別灌胃給予洛伐他汀(4mg·kg-1·d-1)、 AEFE(70、140和420mg·kg-1·d-1),共給藥6周。各組每天灌服等量生理鹽水，灌胃容積為0.5mL/100g體重。結果:AEFE用藥6周后顯示,各劑量組血清膽固醇、甘油三酯和游離脂肪酸、谷丙轉氨酶和谷草轉氨酶均較模型組明顯降低(P lt;005),肝組織丙二醛含量降低和超氧化物歧化酶活性升高,肝脂肪變性和炎癥反應減輕,尤以中劑量組作用最明顯(P lt;001)。AEFE對肝內腫瘤壞死因子α濃度無明顯影響。結論:AEFE改善高脂性大鼠肝臟脂肪變性,此作用可能與其降血脂、抗氧化損傷有關。

Citation： JIANG Yuanming,LIU Yingju,WANG Menghua,et al.. Experimental Observation of Alcohol Extractive of Folium Eucommiae on the Rats with Hyperlipidemia Fatty Liver. West China Medical Journal, 2009, 24(5): 1180-1182. doi: Copy

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1. 戚向陽,喻曉輝,張聲華,等.杜仲的炮制及降壓成分提取工藝的研究[J].中草藥,1997,28(3):144147.
2. 楊鵬遠,芮耀誠,焦亞斌.動脈粥樣硬化大鼠實驗模型的建立[J].第二軍醫大學學報,2003,24(7):802804.
3. 劉菲,鐘嵐,王軍臣.茴三硫防治非酒精性脂肪性肝炎的實驗研究[J].中華消化雜志,2002,22(9):532534.
4. SANYAL A J, CAMPBELLSARGENT C, MIRSHAHI F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities[J]. Gastroenterology,2001,120(5):11831192.
5. FELDSTEIN A E, WERNEBURG N W, CANBAY A, et al. Free fatty acids promotes hepatic lipotoxicity by stimulating TNFα expression via a lysosomal pathway[J]. Hepatology,2004,40:185194.
6. 王本祥.現代中藥藥理與臨床[M].天津:天津科技翻譯出版公司,2004:679683.
7. 張康健,董娟娥,馬柏林,等.杜仲次生代謝物部位差異性的研究[J].林業科學,2002,38(6):1216.
8. 王夢華,李恒華，劉穎菊,等.杜仲葉醇提取物對大鼠血管內皮細胞的保護作用[J].中國老年學雜志,2007,27(18):17661768.
9. 王夢華,劉穎菊,周歧新,等.杜仲葉乙醇提取物抗動脈粥樣硬化作用的實驗研究[J].中成藥,2007,29(11):16871690.

West China Medical Journal

Experimental Observation of Alcohol Extractive of Folium Eucommiae on the Rats with Hyperlipidemia Fatty Liver

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