The Changes and Significance in Coagulative, Anticoagulant and Fibrinolytic System in SnakeBite Patients_West China Medical Journal

Authors：

LIU Xiaohui , LIAO Huawei , ZHANG Jie.

North Sichuan Medical College, Nanchong Sichuan 637000, China;

Corresponding?author：

Keywords：

毒蛇咬傷; 凝血系統; 抗凝系統; 纖溶系統

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目的:觀察蛇傷患者凝血、抗凝和纖溶系統各項指標的變化并探討其臨床意義。方法:以36例蛇傷患者和32例健康體檢者為研究對象,測定血漿凝血酶原時間(PT)、部分凝血活酶時間(APTT)、纖維蛋白原(Fg)、血管性血友病因子(vWF)、凝血酶調節蛋白(TM)、組織型纖溶酶原激活物(tPA)、纖溶酶原激活物抑制物1(PAI1)含量。結果:與正常對照組比較,蛇傷患者PT、APTT、vWF、TM、tPA、PAI1水平明顯升高,Fg水平明顯降低(P lt;001)。結論:蛇傷患者存在凝血、抗凝、纖溶系統的紊亂,早期使用抗蛇毒血清對于防治彌散性血管內凝血(DIC)和多器官功能障礙(MODS)的發生有積極意義。

Citation： LIU Xiaohui,LIAO Huawei,ZHANG Jie.. The Changes and Significance in Coagulative, Anticoagulant and Fibrinolytic System in SnakeBite Patients. West China Medical Journal, 2009, 24(5): 1163-1164. doi: Copy

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1.
2. MARK Rl, F S. Snake venom[J]. Drugs,1997,54(3):110.
3. 覃公平.中國毒蛇學[M].南寧:廣西科學技術出版社,2001:549、617、688.
4. HO KKL, ANDERSON K M, KANNEL W B. Survival after the onset of congestive heart failure in Framingham Hert Study Subjects[J]. Circulation,1993,88(1):107115.
5. BORAWSKI J, MYSLIWIEC M. Soluble thrombomodulin: a marker of endothelial injury, an antithrombotic agent, or both[J]. Med Sci Monit,2001,7(4):785786.
6. 梁廣佳,陳生,王曉忠,等.蛇毒對人體凝血系統的影響[J].江西醫學檢驗,2005,23(6):567568.
7. BELL W R. The fibrinolytic system in neoplasia[J]. Semin Thromb Hemost,1996,22(6):459478.
8. 劉書元,羅潔珍,馮恒基,等.中西醫結合搶救重、危重型毒蛇咬傷體會[J].廣東醫學,2004,25(9):10991101.

West China Medical Journal

The Changes and Significance in Coagulative, Anticoagulant and Fibrinolytic System in SnakeBite Patients

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