Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy_West China Medical Journal

Authors：

1.Department of Nephrology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;2.Department of Endocrinogy,LongChang People’s Hosptial,Longchang 642150,China;

Corresponding?author：

Keywords：

糖尿病腎病; 氧化應激; 阿托伐他汀

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目的:觀察阿托伐他汀對抗糖尿病腎病患者腎氧化損傷作用。方法:56例糖尿病腎病患者隨即分為對照組和阿托伐他汀組。對照組給予降糖、降壓等治療,阿托伐他汀組則在對照組治療基礎上加用阿托伐他汀10 mg/d,療程共12周。檢測兩組患者治療前后FBG、BUN、Scr、尿微量白蛋白以及血脂、血清SOD和MDA水平。結果:12周后兩組患者FBG、BUN、Scr、尿微量白蛋白均較治療前下降;與治療前相比,阿托伐他汀組患者血脂水平較治療前明顯改善,同時患者血清SOD活性增,MDA含量下降,二者之間的差異具有顯著性意義。結論:阿托伐他汀除具有降血脂作用外,還可改善糖尿病腎病患者的氧化應激狀態。

Citation： LIAO Huawei,YANG Tingqiang,YAN Zhongxun,et al. Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy. West China Medical Journal, 2009, 24(3): 670-672. doi: Copy

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7.	王雪艷,匡洪宇,糖尿病與糖尿病腎病患者氧化應激狀態的分析[J].齊齊哈爾醫學院學報,2008,29(6):694..
8.	HENSLEY K,KOBINSON KA,GABBITA,et al.Reactive oxygen species,cell signaling,and cell injury[J].Free Radic Biol Med,2002,28(5):1456-1462..
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1.
2.
3. MARITIM AC,SANDERS RA,WAT KINS JB. Diabetes,oxidative stress,and antioxidants[J].Biochen Mol Toxicol,2003,17(1):24-38..
4. USNI H,SHIKATA K,MAT SUDA M,et al.HMGCoA reductase inhibitor ameliorates diabetic nephropat hy by its pleiotropic effects in rats[J].Nephrol Dial Transplant,2003,18(2):265272..
5. 于冬青,鄧華聰,劉金波,辛伐他汀對糖尿病大鼠腎臟氧化應激的抑制作用[J].中國病理生理雜志,2006,22(4):824-825..
6. JONES SP,TESHIMA Y,AKAO M,et al.Simvastatin at tenuates oxidantinduced mitochondrial dysfunction in cardiac myocytes[J].Circ Res,2003,93(8):697-699..
7. 王雪艷,匡洪宇,糖尿病與糖尿病腎病患者氧化應激狀態的分析[J].齊齊哈爾醫學院學報,2008,29(6):694..
8. HENSLEY K,KOBINSON KA,GABBITA,et al.Reactive oxygen species,cell signaling,and cell injury[J].Free Radic Biol Med,2002,28(5):1456-1462..
9. GRAWEL S,WARDAS M,NIEDWOROK E,et al.Malondialdehyde(MDA)as a lipid peroxidation marker[J].Wiad Lek,2004,57(9-10):453-455..

West China Medical Journal

Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy

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