目的:觀察聚乙二醇干擾素(PEG-INFa)聯合利巴韋林治療慢性丙型肝炎臨床療效。方法:共收集42例慢性丙型肝炎患者,其中治療組24例,采用聚乙二醇干擾素180ug皮下注射,每周1次;對照組18例,采用IFNa2b(賽若金)500萬u皮下注射,隔日1次。兩組均聯合利巴韋林治療,劑量均為800~1200mg/d口服,總療程為48周。分別于治療12周、24周、48周及治療結束后24周評價療效,并觀察藥物副反應。結果:所有患者均完成治療,在治療12周時,治療組早期應答率83.3%,對照組應答率50.0%;在治療24周時,治療組應答率87.5%,對照組應答率61.1%;在治療48周時,治療組完全應答率87.5%,對照組完全應答率55.6%;治療結束后24周,治療組持續應答率75.0%,對照組持續應答率44.4%。主要副反應為不同程度發熱,頭痛,肌肉關節酸痛,白細胞,血紅蛋白及血小板下降,部分患者出現脫發,皮疹皮膚瘙癢,失眠,抑郁等癥狀,予對癥處理后好轉,未影響治療。結論:PEG干擾素聯合利巴韋林治療慢性丙型肝炎療效優于普通干擾素,副反應兩者無明顯差別,患者可以耐受。
Citation：
LIU Fabin,ZHONG Cejun,LU Jiajie,et al.. Treatment on Patients with Chronic Hepatitis C by Peginterferon with Ribavirin. West China Medical Journal, 2009, 24(3): 646-648. doi:
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- 4. FRIED MW,HADZIYANNIS SJ.Trent of chronic hepatitis C:a system review [J].Hepatology,2002,36(5):S135-S144..
- 5. FRIED MW,HADZIYANNIS SJ.Treatment of chronic hepatitis C infetion with peginterferons pius ribavirin [J].Semin Liver Dis,2004,24(Suppl 2):47-54..
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