活動性類風濕關節炎患者IL-18的表達及臨床意義_《華西醫學》

作者：

任敏 ¹ , 武加標 ¹ , 湯麗 ¹ , 肖菁 ¹ , 蔣立新 ²

江蘇大學附屬武進醫院（江蘇常州，213002） 1 風濕免疫科，2 檢驗科;

關鍵詞：

類風濕關節炎白介素-18 細胞因子

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【摘要】　目的　研究活動期RA患者血清中細胞因子IL-18的表達，并探討它們與疾病活動程度的關系。　方法　 2008年12月-2010年1月將63例RA患者，根據DAS28將患者分為高度活動組和低度活動組，應用酶聯免疫吸附法（ELISA）法檢測63例RA患者和27例對照組的白細胞介素-18（IL-18）表達水平。分析IL-18的水平與臨床指標的相關性。　結果　 IL-18在活動期RA中表達水平高于低度活動組、對照組，分別為（238.88±41.75）、（189.11±40.62）、（185.42±44.93） pg/mL，有統計學意義（P lt;0.01）。RA活動組患者IL-18與外周血白細胞計數呈負相關（r=-0.628，P lt;0.05）。　結論　 IL-18水平在RA活動期患者高表達，在RA發病和發展中起重要作用。
【Abstract】　Objective　 To observe the expression of interleukin-18 (IL-18) in patients with active rheumatoid arthritis (RA).　Methods　 A total of 63 patients with RA in our hospital from December 2008 to January 2010 were selected. The patients were divided into high activity group and low activity group according to the disease activity score 28 (DAS28). Levels of IL-18 in the serum in 63 patients and 27 control individuals were detected by ELISA technique. The relationship between IL-18 expression and the clinical indexes was analyzed.　Results　 IL-18 serum levels were (238.88±41.75), (189.11±40.62), and (185.42±44.93) pg/mL In high activity group, low activity group and the control group respectively with a significant difference (P lt;0.01). The IL-18 level in high activity group was negative correlated with WBC counts.　Conclusion　 Apparent expression of IL-18 is found in RA patients at the active phase, which plays an important role in the occurrence and development of RA.

引用本文： 任敏,武加標,湯麗,肖菁,蔣立新. 活動性類風濕關節炎患者IL-18的表達及臨床意義. 華西醫學, 2010, 25(11): 2015-2017. doi: 復制

1.	Klareskog L, Catrina AI, Paget S, et al. Rheumatoid arthritis[J]. Lancet, 2009, 373(9664): 659-672.
2.	Shao XT, Feng L, Gu LJ, et al. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis[J]. Clin Exp Med, 2009, 9(3): 215-221.
3.	曲瑾. 類風濕關節炎關節滑膜細胞中IL-18表達及意義[J]. 山東醫藥, 2008, 48(48): 99-100.
4.	李強, 黃憲章, 丁海明, 等. 外周血白細胞介素-18與類風濕性關節炎相關性研究[J]. 實用醫學雜志, 2007, 23(8): 1143-1144.
5.	Boraschi D, Dinarello CA. IL-18 in autoimmunity: review[J]. Eur Cytokine Netw, 2006, 17(4): 224-252.
6.	Joosten LA, Radstake TR, Lubberts E, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis[J]. Arthritis Rheum, 2003, 48(2): 339-347.
7.	王葉萍, 姚航平. 類風濕性關節炎患者血清和滑液IL-18及IL-18結合蛋白的水平及意義[J]. 檢驗醫學, 2004, 19(6): 518-520.
8.	Bresnihan B, Roux Lombard P, Murphy E, et al. Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis[J]. Ann Rheum Dis, 2002, 61(8): 726-729.
9.	Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis[J]. Arthritis Rheum, 2008, 58(10): 2958-2967.
10.	Bokarewa M, Hultgren O. Is interleukin-18 useful for monitoring rheumatoid arthritis [J]? Scand J Rheumatol, 2005, 34(6): 433-436.
11.	Muhl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory interve-ntion[J]. Eur J Pharmacol, 2004, 500(1): 67-71.
12.	Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis[J]. Rheum Dis Clin North Am, 2004, 30(2): 417-434.
13.	McInnes IB, Liew FY, Gracie JA, et al. Interleukin-18: a therapeutic target in rheumatoid arthritis [J] ? Arthritis Res Ther, 2005, 7(1): 38-41.

1. 　Klareskog L, Catrina AI, Paget S, et al. Rheumatoid arthritis[J]. Lancet, 2009, 373(9664): 659-672.
2. 　Shao XT, Feng L, Gu LJ, et al. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis[J]. Clin Exp Med, 2009, 9(3): 215-221.
3. 　曲瑾. 類風濕關節炎關節滑膜細胞中IL-18表達及意義[J]. 山東醫藥, 2008, 48(48): 99-100.
4. 　李強, 黃憲章, 丁海明, 等. 外周血白細胞介素-18與類風濕性關節炎相關性研究[J]. 實用醫學雜志, 2007, 23(8): 1143-1144.
5. 　Boraschi D, Dinarello CA. IL-18 in autoimmunity: review[J]. Eur Cytokine Netw, 2006, 17(4): 224-252.
6. 　Joosten LA, Radstake TR, Lubberts E, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis[J]. Arthritis Rheum, 2003, 48(2): 339-347.
7. 　王葉萍, 姚航平. 類風濕性關節炎患者血清和滑液IL-18及IL-18結合蛋白的水平及意義[J]. 檢驗醫學, 2004, 19(6): 518-520.
8. 　Bresnihan B, Roux Lombard P, Murphy E, et al. Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis[J]. Ann Rheum Dis, 2002, 61(8): 726-729.
9. 　Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis[J]. Arthritis Rheum, 2008, 58(10): 2958-2967.
10. 　Bokarewa M, Hultgren O. Is interleukin-18 useful for monitoring rheumatoid arthritis [J]? Scand J Rheumatol, 2005, 34(6): 433-436.
11. 　Muhl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory interve-ntion[J]. Eur J Pharmacol, 2004, 500(1): 67-71.
12. 　Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis[J]. Rheum Dis Clin North Am, 2004, 30(2): 417-434.
13. 　McInnes IB, Liew FY, Gracie JA, et al. Interleukin-18: a therapeutic target in rheumatoid arthritis [J] ? Arthritis Res Ther, 2005, 7(1): 38-41.

《華西醫學》

活動性類風濕關節炎患者IL-18的表達及臨床意義

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《華西醫學》

活動性類風濕關節炎患者IL-18的表達及臨床意義

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