【摘要】 目的 探討單次癲癇發作是否會引起腦損傷。 方法 2007年6月-2009年11月，采用電化學發光法檢測癲癇發作后24 h內40例和對照組40例患者血清和腦脊液中神經元特異性烯醇化酶（neuron-specific enolase，NSE）水平，采用ELISA法測定其血清和腦脊液中髓鞘堿性蛋白（myebin bosic protein，MBP）水平。 結果 癲癇組血清和腦脊液中NSE水平明顯高于對照組（P lt;0.01）；癲癇組血清MBP水平與對照組比較差異無統計學意義（P gt;0.05）；癲癇組腦脊液中MBP水平高于對照組（P lt;0.05）。 結論 單次癲癇患者血清和腦脊液中NSE明顯升高，腦脊液中MBP升高，提示單次癲癇發作可導致神經元損傷。
【Abstract】 Objective To detect the possibility of brain damage in the epileptic patients after single episodes. Methods The levels of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) in 40 patients with single episodes within 24 hours after seizures from June 2007 to November 2009 were determined respectively by electrochemiluminescence. Another 40 healthy individuals were enrolled as the control. The levels of myelin basic protein (MBP) were determined by enzyme-linked immunosorbent assay. Results The levels of NSE in the serum and CSF in epileptic group within 24 hours after seizures were significantly higher than those in the control group (P lt;0.01), and the levels of MBP in the serum in the two group didn′t differ much (P gt;0.05). The levels of MBP in CSF in epileptic group were significantly higher than those in the control group (P lt;0.05). Conclusion After single episodes, the levels of NSE in serum and CSF and the levels of NSE in CSF increase,which suggests that single episodes may lead to neuronal damage.
引用本文： 楊小芳,喻明,聶本剛,熊高華. 單次癲癇發作后患者血清和腦脊液中神經元特異性烯醇化酶及髓鞘堿性蛋白的變化. 華西醫學, 2010, 25(11): 2007-2008. doi: 復制