循環腫瘤細胞在乳腺癌患者中的臨床意義_West China Medical Journal

Authors：

龍泉伊 ,  李宏江 , 林小燕

Corresponding?author：

李宏江, Email: 2004-918@163.com

Keywords：

乳腺癌; 循環腫瘤細胞; 轉移; 檢測方法

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【摘要】乳腺癌在腫瘤發展早期就可遠處播散，乳腺癌術后復發和轉移是影響預后的主要因素，在外周血中發現腫瘤細胞即是重要證據，因而提出了循環腫瘤細胞（circulating tumor cell， CTC）的概念。檢測乳腺癌CTC 有助于準確的判斷預后，并為及時評判和監測治療效果提供依據，有利于患者的個體化治療，具有重要的臨床意義。

Citation： 龍泉伊,李宏江,林小燕. 循環腫瘤細胞在乳腺癌患者中的臨床意義. West China Medical Journal, 2010, 25(10): 1927-1929. doi: Copy

1.
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19.	Taubert H, Blumke K, Bilkenroth U, et al. Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases[J]. Gynecol Oncol, 2004, 92(1): 256.
20.	蔡清清, 黃慧強, 林天歆, 等. 乳腺癌患者外周血中循環癌細胞的檢測及其臨床意義[J]. 癌癥, 2005, 24(7): 837-841.
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25.	齊曉偉, 姜軍. 乳腺癌循環腫瘤細胞臨床應用研究進展[J]. 中華腫瘤防治雜志, 2009, 16(5): 394-398.
26.	齊曉偉, 姜軍, 楊新華, 等. 乳腺癌循環腫瘤細胞與原發腫瘤臨床病理特征關系的初步研究[J]. 第三軍醫大學學報, 2009. 31(9): 850-853.

1.
2. 寧連勝, 方志沂, 譯. 現代乳腺疾病治療學[M]. 2版. 北京: 人民衛生出版社, 2007: 489.
3. Hüsemann Y, Geigl JB, Schubert F, et al. Systemic spread is an early step in breast cancer [J]. CancerCell, 2008, 13 (1): 58-68.
4. Racila E, Euhus D, Weiss AJ, et al. Detection and characterization of carcinoma cells in the blood[J]. Proc Natl Acad Sci USA, 1998, 95(8): 4589-4594.
5. Gilbey AM, Burnett D, Coleman RE, et al. The detection of circulating cancer cells in blood[J]. J Clin Pathol, 2004, 57: 903-911.
6. 陳艷, 王熙才, 伍治平. 乳腺癌循環腫瘤細胞[J]. 國際腫瘤學雜志，2008, 35(2): 122-124.
7. Kirk SJ, Cooper GG, Hoper M, et al. The prognostic signifycancer of marrow micrometastases in women with early breast cancer[J]. Eur J Surg Oncol, 1990, 16: 481-485.
8. Osborne M, Rosen P. Detection and management of bone marrow micrometastases in breast cancer[J]. Oncology, 1994, 8: 25-36.
9. Sloane JP, Ormerod MG, Neville AM. Potential pathological application of immunocytochemical methods to the[VAC13] detec tion of micrometastases[J]. Cancer Res, 1980, 40(8): 3079-3082.
10. Irene G, Nicolas S, John N, et al. In vivo flow cytometry: A new method for enumerating circulating cancer cells[J]. Cancer Res, 2004, 64: 5044-5047.
11. Lee GS, Ryu KS, Rha JG, et al. Multiparametric flow cytometric analysis in a breast cancer cell line (MCF-7)[J]. J Obstet Gynaecol Res, 2002, 28(3): 141-148.
12. 孔雁, 姜達. 循環腫瘤細胞的研究進展[J]. 中國腫瘤, 2006, 15(3): 172-175.
13. 趙洪猛, 張斌, 湯小川, 等. 乳腺癌循環腫瘤細胞研究及其檢測進展[J]. 中國腫瘤臨床, 2009, 36(15): 896-899.
14. Ring A, Smith IE, Dowsett M. Circulating tumor cells in breast cancer[J]. Lancet Oncol, 2004, 5(2): 79-88.
15. 李燕, 李大鵬, 馬德亮, 等. 乳腺癌患者循環腫瘤細胞的檢測及其臨床應用[J]. 中國腫瘤外科雜志. 2010, 2(1):.
16. 鄭建, 李麗. 循環腫瘤細胞在乳腺癌中的研究現狀[J]. 現代腫瘤學, 2009, 17, (6): 1158-1162.
17. Mikhitarian K, Martin RH, Ruppel MB, et al. Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study[J]. BMC Cancer, 2008, 8: 55.
18. Stathopoulou A, Gizi A, Perraki M, et al. Real- time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system[J]. Clin Cancer Res, 2003, 9(14): 5145.
19. Taubert H, Blumke K, Bilkenroth U, et al. Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases[J]. Gynecol Oncol, 2004, 92(1): 256.
20. 蔡清清, 黃慧強, 林天歆, 等. 乳腺癌患者外周血中循環癌細胞的檢測及其臨床意義[J]. 癌癥, 2005, 24(7): 837-841.
21. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J]. N Engl J Med, 2004, 351(8): 781.
22. Wong NS, Kahn HJ, Zhang L, et al. Prognostic significance of circulating tumor cells enumerated after filtration enrichment in early and metastatic breast cancer patients [J]. Breast Cancer Res Treat, 2006, 99(1): 63-69.
23. Müller S, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity[J]. Clin Cancer Res, 2005, 11(10): 3678-3685.
24. Lobodasch K, Frohlich F, Rengsberger M, et al. Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: An increase in cell number at completion of therapy is a predictor of early relapse [J]. The Breast, 2007, 16: 211-218.
25. 齊曉偉, 姜軍. 乳腺癌循環腫瘤細胞臨床應用研究進展[J]. 中華腫瘤防治雜志, 2009, 16(5): 394-398.
26. 齊曉偉, 姜軍, 楊新華, 等. 乳腺癌循環腫瘤細胞與原發腫瘤臨床病理特征關系的初步研究[J]. 第三軍醫大學學報, 2009. 31(9): 850-853.

West China Medical Journal

循環腫瘤細胞在乳腺癌患者中的臨床意義

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