【摘要】 目的  觀察使用芐星青霉素正規治療早期顯性梅毒的臨床療效以及分析治療前后的梅毒血清學試驗結果。 方法  選擇2006年6月-2007年12月門診就診有皮膚損害的早期梅毒患者48例，病程 lt;2年，采用芐星青霉素240萬U，肌內注射，1次/周，連續3周治療。治療后隨訪第3、6、9、12、18、24個月時的TRUST滴度。 結果  48例早期梅毒患者經治療后1個月內皮損均消失。總的血清轉陰率為66.67%。一期梅毒在治療后3、6個月時的TRUST轉陰率較二期梅毒高（P lt;0.05）。治療前TRUST≥1∶8者TRUST滴度在治療后下降較TRUST≤1∶4者快（P lt;0.05）。 結論  早期梅毒病程越短，治愈越快。治療前血清學滴度越高，治療后滴度下降越快。梅毒的治療應強調早期、規范。
【Abstract】 Objective  To analyze the clinical efficiency and pre- and post- therapy serological results of benzathine benzylpenicillin treated for early symptomatic syphilis. Methods  A total of 48 patients with early symptomatic syphilis diagnosed from June 2006 to December 2007 (the disease duration lt;2 years) were treated with benzathine benzylpenicillin. The patients underwent the intramuscular injection with 2.4 million units benzathine benzylpenicillin once per week (for continuous 3 weeks). The results of TRUST were detected 3,6,9,12,18,and 24 months after the treatment. Results  All patients cured clinically within one month. The general seronegative rate was 66.67%. Three and six months after the treatment, the seronegative rate of primary syphilis were higher than that of secondary syphilis (P lt;0.05). The TRUST titer dropped faster after the treatment in the ones whose TRUST titer was ≥1∶8 than those whose TRUST titer was ≤1∶4 (P lt;0.05). Conclusion  The shorter the duration of infection is, the faster the treatment may be. The higher the TRUST titers before the treatment are, the faster the titers decrease is. The treatment on syphilis should be as early as possible.

引用本文： 劉趙明. 芐星青霉素治療早期顯性梅毒的療效分析. 華西醫學, 2010, 25(10): 1849-1851. doi: 復制