果糖胺與血糖、糖化血紅蛋白的關系研究_《華西醫學》

作者：

余霆 , 黃志剛

四川大學華西醫院實驗醫學科臨床生化室（成都，610041）;

關鍵詞：

果糖胺糖尿病血糖糖化血紅蛋白

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【摘要】目的探討果糖胺（fructosamine，FMN）與血糖、糖化血紅蛋白（HbA1c）的關系。方法 2009年5月-2009年8月，以75例糖尿病患者作為糖尿病組，36例健康志愿者作為正常對照組，進行口服糖耐量試驗，檢測其空腹血糖及餐后2 h血糖水平，并同時檢測FMN與HbA1c水平。結果糖尿病組空腹血糖、餐后2 h血糖、FMN、HbA1c均高于正常對照組（P lt;0.05）。FMN與HbA1c、空腹血糖、餐后2 h血糖均呈正相關關系（P lt;0.05）。FMN與空腹血糖的相關系數高于HbA1c與空腹血糖的相關系數，FMN與餐后血糖的相關系數也高于HbA1c與餐后血糖的相關系數。結論果糖胺與HbA1c相比有一定的優勢，可作為監測糖尿病患者血糖控制的良好指標。
【Abstract】Objective To investigate the association among fructosamine (FMN) and blood glucose, glycated hemoglobin (HbA1c). Methods From May 2009 to April 2009, 75 diabetes and 36 health subjects were recruited for this study. Blood samples was collected and assayed for FMN, HbA1C, and fasting glucose.The 2-hour oral glucose tolerance test (OGTT-2h) was given. Results Fasting glucose, OGTT-2h glucose, FMN and HbA1c were all higher in diabetes group than in healthy control group (P lt;0.05) .There was positive correlation between FMN and fasting glucose, OGTT-2h glucose, and HbA1c (P lt;0.05). The correlation coefficients between FMN and glucose were higher than those between HbA1c and glucose. Conclusion Compared with HbA1c, FMN has advantage in monitoring blood glucose in diabetes and be regarded as a suitable index for blood glucose control.

引用本文： 余霆,黃志剛. 果糖胺與血糖、糖化血紅蛋白的關系研究. 華西醫學, 2010, 25(7): 1325-1327. doi: 復制

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2.	Kimberly MM, Vesper HW, Caudill SP, et al. Variability among five over-the-counter blood glucose monitors[J]. Clinica Chimica Acta, 2006, 364(1-2): 292-297.
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5.	Saudek CD, Derr RL, Kalyani RR. Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c[J]. JAMA, 2006, 295(14): 1688-1697.
6.	Taylor JR, Campbell KM. Home monitoring of glucose and blood pressure[J]. Am Fam Physician, 2007, 76(2): 255-260.
7.	Renard E. Monitoring glycemic control: the importance of self-monitoring of blood glucose[J]. Am J Med, 2005, 118(Suppl 9A): 12S-19S.
8.	Klonoff DC. Serum fructosamine as a screening test for type 2 diabetes[J]. Diabetes Technol Ther, 2000, 2(4): 537-539.
9.	Lindsey CC, Carter AW, Mangum S, et al. A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care[J]. Diabetes Technol Ther, 2004, 6(3): 637-642.
10.	Misciagna G, Logroscino G, De Michele G, et al. Fructosamine, glycated hemoglobin, and dietary carbohydrates[J]. Clin Chim Acta, 2004, 340(1-2): 139-147.
11.	Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)[J]. Diabetes Care, 2003, 26: 881-885.
12.	胡興國, 張云翔, 曾因明．危重病人應激性高血糖的研究進展[J]．國外醫學?麻醉學與復蘇分冊, 2005, 26(3): 140-143．.

1. 賈偉平. 血糖控制達標是預防糖尿病并發癥的關鍵[J]. 上海醫學, 2005, 28(1): 1-3.
2. Kimberly MM, Vesper HW, Caudill SP, et al. Variability among five over-the-counter blood glucose monitors[J]. Clinica Chimica Acta, 2006, 364(1-2): 292-297.
3. Kendall DM, Kaplan RA, Paulson CF, et al. Accuracy and utility of a 10-test disk blood glucose meter[J]. Diabetes Res Clini Practice, 2005, 67(1): 29-35.
4. Parramon M. Easier and more comfortable measurement of capillary glycemia: the objective of a new electrochemical coulometric device “freestyle papillon mini”[J]. Revista de Enfermeria. 2005, 28(9): 53-56.
5. Saudek CD, Derr RL, Kalyani RR. Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c[J]. JAMA, 2006, 295(14): 1688-1697.
6. Taylor JR, Campbell KM. Home monitoring of glucose and blood pressure[J]. Am Fam Physician, 2007, 76(2): 255-260.
7. Renard E. Monitoring glycemic control: the importance of self-monitoring of blood glucose[J]. Am J Med, 2005, 118(Suppl 9A): 12S-19S.
8. Klonoff DC. Serum fructosamine as a screening test for type 2 diabetes[J]. Diabetes Technol Ther, 2000, 2(4): 537-539.
9. Lindsey CC, Carter AW, Mangum S, et al. A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care[J]. Diabetes Technol Ther, 2004, 6(3): 637-642.
10. Misciagna G, Logroscino G, De Michele G, et al. Fructosamine, glycated hemoglobin, and dietary carbohydrates[J]. Clin Chim Acta, 2004, 340(1-2): 139-147.
11. Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)[J]. Diabetes Care, 2003, 26: 881-885.
12. 胡興國, 張云翔, 曾因明．危重病人應激性高血糖的研究進展[J]．國外醫學?麻醉學與復蘇分冊, 2005, 26(3): 140-143．.

《華西醫學》

果糖胺與血糖、糖化血紅蛋白的關系研究

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《華西醫學》

果糖胺與血糖、糖化血紅蛋白的關系研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

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