【摘要】 目的  觀察黃精多糖（polygonatum sibiricmu polysaccharides，PSP）對老齡大鼠血液中老化相關酶的影響。 方法  取老齡（15～16月齡）SD大鼠。每組15只，均采用灌胃給藥。陰性對照組灌服等體積的0.5%羧甲基纖維素（CMCNa）；陽性對照組給予甲磺酸雙氫麥角堿0.5 mg/kg；PSP大劑量組222 mg/（kg·d）；PSP中劑量組111 mg/（kg·d）；PSP小劑量組55 mg/（kg·d）；另取9只青年SD大鼠，作為青年對照組，灌服等體積的0.5% CMCNa。每日1次，連續4周，末次給藥后取血，檢測老化相關酶:超氧化物歧化酶（SOD）、過氧化脂質（LPO）、脂褐質（LF）、B型單胺氧化酶（MAO-B）。各項指標進行統計分析，比較各組差異。 結果  PSP高、中劑量組的SOD水平明顯提高，而LPO、LF和MAO-B水平明顯下降。 結論  PSP有較明確的延緩衰老作用。
【Abstract】 Objective  To observe the effects of Polygonatum sibiricmu polysaccharides (PSP) on enzymes related to the aging in the blood of aged rats. Methods  Seventy-five aged rats (15-16 months) were divided into 5 groups randomly containing 15 rats in each group. The rats of each group were treated with different medicines daily for 4 weeks by gavage: negative control group received 0.5% CMCNa; positive control group received dihydroer gotoxine of 0.5 mg/kg; high dose group of PSP received PSP of 222 mg/(kg·d); middle dose group of PSP received PSP of 111 mg/(kg·d); low dose group of PSP received PSP of 55 mg/(kg·d). Another 9 young rats (4 male and 5 female rats) were chosn as an additional control group to study the reaction of youth, which received 0.5% CMCNa by gavage. The enzymes about aging were detected after the last treatment, such as superoxide dismutase (SOD), lactoperoxidase (LPO), lipofuscin (LF), monoamine oxidase type B (MAO-B). Statistical analysis was used to judge the differences of all groups. Results  The blood level of SOD in high and middle dose groups of PSP were significantly increased while the blood level of LPO, LF, MAO-B were decreased with markable differences. Conclusion  PSP has an obvious effect of anti-aging.

引用本文： 劉萍. 黃精多糖對老齡大鼠老化相關酶的影響. 華西醫學, 2010, 25(7): 1259-1261. doi: 復制