Bundle Therapy in Five Severe Patients with Influenza A (H1N1)_West China Medical Journal

Authors：

YANG Mingquan , XIAO Guohui

Intensive Care Uint, the First People’s Hospital of Zigong, Zigong, Sichuan 643000, P. R. China;

Corresponding?author：

Keywords：

甲型HlN1流感; 危重患者; 集束化治療

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【摘要】　目的　探討甲型H1N1流感危重癥患者的搶救療效。　方法　 2009年10月－2010年1月，對我院ICU收治5例甲型H1N1流感危重癥患者采用集束化治療方案進行救治，并就患者的器官功能變化進行評價。　結果　 5例患者平均住院天數為（11.8±5.59）d，4 例存活，1例死亡。存活患者在治療過程中急性生理和既往健康（APACHE）Ⅱ、多器官功能障礙綜合征評分（MODS）、全身性感染相關的器官衰竭評分（SOFA）總體呈逐漸下降趨勢。死亡者APACHEⅡ、SOFA評分均呈逐漸升高趨勢。　結論　對甲型H1N1流感危重癥患者采取集束化救治療效良好。
【Abstract】　Objective　 To explore the effect of bundle therapy on severe patients with influenza A (H1N1).　Methods　 Bundle therapy were used in 5 severe patients with influenza A from October 2009 to January 2010. The patients’ organ dysfunction were observed for.　Results　 The average in-hospital duration was (11.80±5.59) days. Four patients survived and one died with the survival ratio of 80%. Acute physiology and chronic health evaluation (APACHE) II score, Multiple organ dysfunction syndrome (MODS) score and sepsis-related organ failure assessment (SOFA) score gradually decreased in 4 survived patients, while gradually increased in the died patient.　Conclusion　 Bundle therapy is effective on patients with severe influenza A.

Citation： YANG Mingquan,XIAO Guohui. Bundle Therapy in Five Severe Patients with Influenza A (H1N1). West China Medical Journal, 2011, 26(7): 1022-1024. doi: Copy

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1. 　中華人民共和國衛生部. 甲型H1Nl流感診療方案(2009年試行版第三版)[J]. 傳染病信息, 2009, 22(3): 1-3.
2. 　Agarwal PP, Cinti S, Kazerooni EA. Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus(S-OlV) infection[J]. AJR Am J Roentgenol, 2009, 193(6): 1488-1493.
3. 　朱玉春, 王建良, 劉麗華, 等. 6例重癥甲型H1N1流感的肺部CT影像分析[J]. 中國醫學影像學雜志, 2011, 19(2): 149-152.
4. 　Chowell G, Bertozzi SM, Cochero MA, et al. Severe respiratory disease concurrent with the circulation of HlN1 influenza[J]. N Engl J Med, 2009, 361(7): 674-679.
5. 　Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin inf1uenza A(H1N1)in Mexico[J]. N Engl J Med, 2009, 361(7): 680-689.
6. 　李華, 馬如存. 青海省75例重癥甲型H1N1流感患者臨床分析[J]. 中國危重病急救醫學, 2010, 22(3): 164-165.
7. 　李秀惠, 夏章, 田一梅, 等. 新型甲型H1 N1流感重癥17例臨床特征分析[J]. 環球中醫藥, 2010, 3(1): 13-17.
8. 　寇國先, 熊鳳鳴, 韓愛華, 等. 重癥與危重甲型H1N1流感40例臨床分析[J]. 浙江臨床醫學, 2011, 13(3): 262-264.

West China Medical Journal

Bundle Therapy in Five Severe Patients with Influenza A (H1N1)

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