【摘要】 目的 了解不同糖代謝狀態的人群空腹及口服葡萄糖耐量實驗（oral glucose tolerance test，OGTT）餐后胰高血糖素樣態-1（GLP-1）和葡萄糖依賴的促胰島素多態（GIP）水平。 方法 將受試者根據OGTT結果分為3組:正常糖耐量組（NGT，n=61例），糖耐量受損組（IGT，n=53）和2型糖尿病組（T2DM， n=66）。采空腹及糖餐后2 h靜脈血檢測GLP-1和GIP水平。 結果 T2DM組空腹GLP-1水平低于NGT和IGT組（P lt;0.05）。NGT和IGT的空腹GLP-1水平差異無統計學意義（P gt;0.05）。餐后GLP-1水平三組差異無統計學意義（P gt;0.05）。空腹及餐后GIP水平在NGT、IGT和T2DM均呈逐漸增加的趨勢，而且同OGTT-0 h和OGTT-2 h血糖水平呈正相關（r=0.384，0.426；P lt;0.05）。 結論 不同的GLP-1和GIP水平也許是IGT和T2DM胰島素分泌能力不同的原因之一。
【Abstract】 Objective To investigate the fasting, and after oral glucose tolerance test (OGTT), the postprandial levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in Chinese people with different degrees of glucose tolerance. Methods Based on the results of OGTT, 180 subjects were divided into three groups: normal glucose tolerance group (NGT group, n=61), impaired glucose tolerance group (IGT group, n=53) and type-2 diabetes mellitus group (T2DM group, n=66). Fasting venous blood and the venous blood 2 hours after OGTT was sampled to detect GLP-1 and GIP levels. Results The fasting GLP-1 level in the T2DM group was significantly lower than that in the NGT and IGT groups (P lt;0.05). There was no significant difference in fasting GLP-1 level between NGT and IGT groups (P gt;0.05). There was no significant difference in GLP-1 level 2 hours after OGTT among all the three groups (P gt;0.05). GIP level gradually increased in the order of NGT, IGT and T2DM both before and after glucose load, and it was positively correlated with glucose levels just after OGTT and 2 hours after OGTT (r=0.384,0.426;P lt;0.05). Conclusion Different GLP-1 and GIP levels may be one of the reasons for different insulin secretion ability between IGT and T2DM
引用本文： 鄔云紅,田浩明,張祥訊,陳香. 不同糖耐量水平人群血漿胰高血糖素樣肽-1和葡萄糖依賴的促胰島素樣多肽水平比較. 華西醫學, 2011, 26(7): 1018-1021. doi: 復制