乙酰肝素酶與糖尿病腎病_West China Medical Journal

Authors：

安麗娜 ¹ ,  李娟 ²

Corresponding?author：

李娟, Email: lina1217146983@163.com

Keywords：

乙酰肝素酶; 蛋白尿; 糖尿病腎病

Video：

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【摘要】　乙酰肝素酶（heparanase，HPA）是目前發現的哺乳動物細胞中唯一能切割細胞外基質中硫酸肝素蛋白多糖側鏈的內源性糖苷酶。因其可促進腫瘤細胞的浸潤和轉移，還可以促進腫瘤細胞生長和微血管形成，而被視為是抗腫瘤、抗炎癥的理想靶點。研究表明HPA可以降解腎小球基底膜硫酸乙酰肝素多糖側鏈，造成腎小球基底膜選擇性濾過蛋白質功能下降，與糖尿病腎病（diabetic nephropathy，DN）蛋白尿的產生密切相關。HPA活性的高低對糖尿病腎病的研究有著重要的意義。現將HPA與DN之間的研究進展作一綜述。

Citation： 安麗娜,李娟. 乙酰肝素酶與糖尿病腎病. West China Medical Journal, 2011, 26(6): 854-856. doi: Copy

1.	葉任高, 陸再英. 內科學[M]. 6版. 北京: 人民衛生出版社, 2004: 794-797.
2.	李燕杰, 李淑蓮. 乙酰肝素酶的分子特性及其在生理病理過程中的作用[J]. 河南大學學報(醫學版), 2008, 27(3): 14-16.
3.	Dong J, Kukula AK, Toyoshima M, et al. Genomic organization and chromosome localization of the newly identified human heparanase gene[J]. Gene, 2000, 253(2): 171-178.
4.	張文娟, 任明姬. 乙酰肝素酶研究進展[J]. 內蒙古醫學雜志, 2010, 42(2): 202-205.
5.	Vlodavsky I, Friedmann Y, Elkin M. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis[J]. Nat Med, 1999, 5(7): 793-802.
6.	Mckenzie E, Tyson K, StampsA, et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member[J]. Biochem Biolphy Res Commum, 2000, 276(3): 1170-1177.
7.	Bame KJ. Heparanase:endoglycosidases that degrade heparan sulfate proteglycans[J]. Glycobiology, 2001, 11(6): 91-98.
8.	李燕杰, 彭清忠. 乙酰肝素酶的結構、功能及調控[J]. 生物技術通訊, 2003, 14(2): 141-144.
9.	Raats CJ, Van Den Born J, Berden JH. Glomerular heparan sulfate alternations: mechanisms and relevance for proteinuria[J]. Kidney Int, 2000, 57(2): 385-400.
10.	Pillarisetti S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans(perlecan)and atherogenicity[J]. Trends Cardiovasc Med, 2000, 10(2): 60-65.
11.	倪壽翔, 李立. 乙酰肝素酶的研究進展與眼部疾病[J]. 重慶醫科大學學報, 2006, 31(1): 65-68.
12.	閻妍, 王崢, 羅葦. 腎病鼠外周血白細胞乙酰肝素酶基因的表達及其與尿蛋白的相關性[J]. 四川大學學報(醫學版), 2004, 35(4): 489-491.
13.	Levidiotis V, Kanellis J, lerino FL, et al. Increased expmssion of heparanasein pummycin aminonucleoside nephrosis[J]. Kidney Int, 2001, 60(4): 1287-1296.
14.	Katz A, Van-Dijk DJ, Aingorn H, et al. Involvement of human heparanase in the pathogenesis of diabetic nephropathy[J]. Isr Med Assoc J, 2002, 4(11): 996-1002.
15.	Maxhimer JB, Somenek M, Rao G, et al. Heparanase-l gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients[J]. Diabetes, 2005, 54(7): 2172-2178.
16.	劉靜云. 淺析糖尿病腎病與尿蛋白的關系[J]. 河北中醫雜志, 2009, 31(8): 1141-1191.
17.	唐立平, 唐政權, 孫洪華. 糖尿病腎病的早期診斷及其臨床意義[J]. 中國實用醫藥雜志, 2010, 5(25): 250.
18.	粱琳瑯, 劉國良. 糖尿病性蛋白尿用藥選擇性研究[J]. 中華內分泌代謝雜志, 1996, 12(3): 138-140.
19.	洪郁芝, 徐新鵬, 葉迅, 等. 糖尿病腎病蛋白尿發生機制研究進展[J]. 中國中西醫結合腎病雜志, 2008, 9(11): 1011-1013.
20.	Shafat I, Zcharia E, Nisman B, et al. An ELISA method for the detection and quantification of human heparanase[J]. Biochem Biophys Res Commun, 2006, 341(4): 958-963.
21.	Zcharia E, Metzger S, Chajek-Shaul T, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan in tissue morphogenesis, vascularization, and feeding behavior[J]. FASEB J, 2004, 18(2): 252-263.
22.	屈微, 張延麗. 乙酰肝素酶在妊娠期高血壓疾病大鼠腎臟的表達及低分子量肝素干預治療[J]. 中外醫療, 2010, 29(1): 24-27.
23.	Ma P, Luo Y, Zhu X, et al. Retinal heparanase expression in streptozotocin-induced diabetic rats[J]. Can J Ophthalmol, 2010, 45(1): 46-51.
24.	van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic nephropathy[J]. Kidney Int, 2006, 70(12): 2100-2108.
25.	王玉華, 唐琳, 劉章鎖. 乙酰肝素酶與蛋白尿性腎臟疾病的關系[J]. 國際移植與血液凈化雜志, 2007, 5(4): 10-15.

1. 　葉任高, 陸再英. 內科學[M]. 6版. 北京: 人民衛生出版社, 2004: 794-797.
2. 　李燕杰, 李淑蓮. 乙酰肝素酶的分子特性及其在生理病理過程中的作用[J]. 河南大學學報(醫學版), 2008, 27(3): 14-16.
3. 　Dong J, Kukula AK, Toyoshima M, et al. Genomic organization and chromosome localization of the newly identified human heparanase gene[J]. Gene, 2000, 253(2): 171-178.
4. 　張文娟, 任明姬. 乙酰肝素酶研究進展[J]. 內蒙古醫學雜志, 2010, 42(2): 202-205.
5. 　Vlodavsky I, Friedmann Y, Elkin M. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis[J]. Nat Med, 1999, 5(7): 793-802.
6. 　Mckenzie E, Tyson K, StampsA, et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member[J]. Biochem Biolphy Res Commum, 2000, 276(3): 1170-1177.
7. 　Bame KJ. Heparanase:endoglycosidases that degrade heparan sulfate proteglycans[J]. Glycobiology, 2001, 11(6): 91-98.
8. 　李燕杰, 彭清忠. 乙酰肝素酶的結構、功能及調控[J]. 生物技術通訊, 2003, 14(2): 141-144.
9. 　Raats CJ, Van Den Born J, Berden JH. Glomerular heparan sulfate alternations: mechanisms and relevance for proteinuria[J]. Kidney Int, 2000, 57(2): 385-400.
10. 　Pillarisetti S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans(perlecan)and atherogenicity[J]. Trends Cardiovasc Med, 2000, 10(2): 60-65.
11. 　倪壽翔, 李立. 乙酰肝素酶的研究進展與眼部疾病[J]. 重慶醫科大學學報, 2006, 31(1): 65-68.
12. 　閻妍, 王崢, 羅葦. 腎病鼠外周血白細胞乙酰肝素酶基因的表達及其與尿蛋白的相關性[J]. 四川大學學報(醫學版), 2004, 35(4): 489-491.
13. 　Levidiotis V, Kanellis J, lerino FL, et al. Increased expmssion of heparanasein pummycin aminonucleoside nephrosis[J]. Kidney Int, 2001, 60(4): 1287-1296.
14. 　Katz A, Van-Dijk DJ, Aingorn H, et al. Involvement of human heparanase in the pathogenesis of diabetic nephropathy[J]. Isr Med Assoc J, 2002, 4(11): 996-1002.
15. 　Maxhimer JB, Somenek M, Rao G, et al. Heparanase-l gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients[J]. Diabetes, 2005, 54(7): 2172-2178.
16. 　劉靜云. 淺析糖尿病腎病與尿蛋白的關系[J]. 河北中醫雜志, 2009, 31(8): 1141-1191.
17. 　唐立平, 唐政權, 孫洪華. 糖尿病腎病的早期診斷及其臨床意義[J]. 中國實用醫藥雜志, 2010, 5(25): 250.
18. 　粱琳瑯, 劉國良. 糖尿病性蛋白尿用藥選擇性研究[J]. 中華內分泌代謝雜志, 1996, 12(3): 138-140.
19. 　洪郁芝, 徐新鵬, 葉迅, 等. 糖尿病腎病蛋白尿發生機制研究進展[J]. 中國中西醫結合腎病雜志, 2008, 9(11): 1011-1013.
20. 　Shafat I, Zcharia E, Nisman B, et al. An ELISA method for the detection and quantification of human heparanase[J]. Biochem Biophys Res Commun, 2006, 341(4): 958-963.
21. 　Zcharia E, Metzger S, Chajek-Shaul T, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan in tissue morphogenesis, vascularization, and feeding behavior[J]. FASEB J, 2004, 18(2): 252-263.
22. 　屈微, 張延麗. 乙酰肝素酶在妊娠期高血壓疾病大鼠腎臟的表達及低分子量肝素干預治療[J]. 中外醫療, 2010, 29(1): 24-27.
23. 　Ma P, Luo Y, Zhu X, et al. Retinal heparanase expression in streptozotocin-induced diabetic rats[J]. Can J Ophthalmol, 2010, 45(1): 46-51.
24. 　van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic nephropathy[J]. Kidney Int, 2006, 70(12): 2100-2108.
25. 　王玉華, 唐琳, 劉章鎖. 乙酰肝素酶與蛋白尿性腎臟疾病的關系[J]. 國際移植與血液凈化雜志, 2007, 5(4): 10-15.

West China Medical Journal

乙酰肝素酶與糖尿病腎病

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