【摘要】　目的　 觀察單用二甲雙胍與二甲雙胍聯合阿卡波糖對2型糖尿病（type 2 diabetes mellitus，T2DM）降糖作用的臨床療效。　方法　 對2010年1—10月就診有典型易饑多食的T2DM患者45例，隨機分為二甲雙胍組20例和二甲雙胍聯合阿卡波糖25例，療程12周。　結果　 二甲雙胍組與二甲雙胍聯合阿卡波糖組治療后對患者的饑餓感和食量改善差異有統計學意義（P lt;0.05），空腹及餐后血糖差異（P lt;0.01）、空腹血糖達標比例差異（P lt;0.01）、餐后血糖達標比例差異（P lt;0.05）均有統計學意義。　結論　 二甲雙胍聯合阿卡波糖能顯著改善T2DM患者的食欲及食量，從而明顯降低空腹及餐后血糖。
【Abstract】　Objective　 To observe and compare the clinical affects and curative effects between using metformin and metformin plus acarbose in the treatment of type 2 diabetes mellitus (T2DM).　Methods　 From January to October 2010, 45 T2DM patients with common symptoms of easy-starving and overeating were randomized into two groups and treated for 12 weeks with either metformin (n=20) or metformin plus acarbose (n=25).　Results　 After the treatment, significant differences were found between the two groups in the improvement on patients’ sense of starving and quantity of eating (P lt;0.05), fasting and postprandial blood glucose (P lt;0.01), up-to-standard rate of fasting blood glucose (P lt;0.01), and up-to-standard rate of postprandial blood glucose (P lt;0.05).　Conclusion　 The combination of metformin and acarbose can substantially improve the appetite and quantity of eating for patients with T2DM, hence significant reductions of fasting and postprandial blood glucose level can be feasibly achieved.

引用本文： 吳曉梅. 二甲雙胍聯合阿卡波糖對2型糖尿病降糖作用的臨床療效評價. 華西醫學, 2011, 26(6): 832-834. doi: 復制