【摘要】　目的　 探討燈盞花素注射液聯合血管緊張素轉換酶抑制劑（ACEI）依那普利治療糖尿病早期腎病的臨床效果。　方法　 2006年10月-2009年12月，將59例臨床確診2型糖尿病早期腎病的患者隨機分為治療組（n=30）與對照組（n=29）。對照組在基本治療的基礎上應用依那普利，治療組在基本治療的基礎上聯合應用依那普利和燈盞花素注射液，療程均為3周。觀察治療前后兩組患者24 h尿微量白蛋白排泄率（UAER）、全血黏度、血漿黏度、甘油三酯（TG）、尿素氮（BUN）、血肌酐（SCr）的變化。　結果　 兩組患者治療前后自身對比，24 h UAER均有明顯下降（P lt;0.05）；治療組UAER下降較對照組更為明顯（P lt;0.05）。　結論　 ACEI聯合燈盞花素，其降低24 h UAER療效優于單純ACEI療效，還可有效降低全血黏度和血漿黏度，降低纖維蛋白原含量，改善患者血液流變性。
【Abstract】　Objective　 To investigate the therapeutic effects of breviscapine combined with angiotensin converting enzyme inhibitor (enalapril) on early diabetic nephropathy. 　Methods　 A total of 59 patients with early diabetic nephropathy diagnosed between October 2006 and December 2009 were randomly divided into treatment group (n=30) and control group (n=29). The patients in treatment group were treated by breviscapine combined with enalapril, while the patients were treated with only enalapril in the control group. All of the patients were treated for three weeks. Urinaryalbuminexcretion (UAE), whole blood viscosity, plasma viscosity, triglycercide, blood urea nitrogen and serum creatinine in the two groups were detected before and after the treatment.　Results　 After the threatment, UAE decreased in both of the two groups compared with the value before the treatment (P lt;0.05); the decrease in treatment groups was more obvious than that in the control group (P lt;0.05).　Conclusion　 The combination of breviscapine and enalapril is effective on early diabetic nephropathy.

引用本文： 鐘莉,黎珂. 燈盞花素注射液結合依那普利治療早期糖尿病腎病臨床療效評價. 華西醫學, 2011, 26(4): 493-495. doi: 復制